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Research Article | Open Access

Preparation and Antibacterial Activity of New Azo-Schiff Thiazol Ligand and Some of its Metal Complexes

Eateman Salah Mahdi( ), Raheem Tahir Mahdi Al-Sa'edi
Department of Chemistry, College of Education for Girls, University of Kufa, An Najaf, Iraq
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Abstract

New chelate compounds, with general formula [M(HL1)2](H2O)2, M = Co(Ⅱ), Ni(Ⅱ), Cu(Ⅱ)] and [M(HL1)2](H2O), M = Zn(Ⅱ), Cd(Ⅱ), Hg(Ⅱ), were prepared by reacting chlorid salt of these metals with the new azo Schiff-base ligand 4-((E)-(3-bromo phenyl)diazenyl)-2-((E)-(thiazol-2-ylimino) methylphenol HL1 using the coupling of diazonium salt of 3-bromoaniline with (E)-2-(thiazol-2-ylimino) methyl phenol. The new azo Schiff thiazol ligand and its chelate complexes were characterized by available spectra and analytical methods such as mass spectra, proton nuclear magnetic resonance (1H-NMR), infrared (IR) spectroscopy, ultraviolet-visible spectroscopy (UV-Vis), elemental analysis (CHN), molar conductivity and magnetic susceptibility measurements. Results showed that the ratio of metal: ligand was 1:2, and also showed that Co(Ⅱ), Ni(Ⅱ), and Cu(Ⅱ) chelate complexes had octahedral geometry, while Zn(Ⅱ), Cd(Ⅱ) and Hg(Ⅱ), had tetrahedral geometry. The ligand with its complexes was tested in vintor against the sensitive organisms, including Staphylococcus aureus (gram positive) and Pseudomonas aeruginosa (gram negative). The study showed that the prepared metal complexes had more biological affectivity than the ligands themselves.

Keywords

Azo-Schiff thiazolChelate complexesBiological study

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Nano Biomedicine and Engineering
Volume 10 Issue 4,
December 2018
Pages 369-378
DOI: 10.5101/nbe.v10i4.p369-378
Cite this article:
Mahdi ES, Al-Sa'edi RTM. Preparation and Antibacterial Activity of New Azo-Schiff Thiazol Ligand and Some of its Metal Complexes. Nano Biomedicine and Engineering, 2018, 10(4): 369-378. https://doi.org/10.5101/nbe.v10i4.p369-378

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Received: 07 July 2018
Accepted: 23 July 2018
Published: 19 November 2018
© Eateman Salah Mahdi, Raheem Tahir Mahdi AlSa›edi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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