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Research Article | Open Access

Preparation and Antibacterial Activity of New Azo-Schiff Thiazol Ligand and Some of its Metal Complexes

Eateman Salah Mahdi( ), Raheem Tahir Mahdi Al-Sa'edi
Department of Chemistry, College of Education for Girls, University of Kufa, An Najaf, Iraq
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Abstract

New chelate compounds, with general formula [M(HL1)2](H2O)2, M = Co(Ⅱ), Ni(Ⅱ), Cu(Ⅱ)] and [M(HL1)2](H2O), M = Zn(Ⅱ), Cd(Ⅱ), Hg(Ⅱ), were prepared by reacting chlorid salt of these metals with the new azo Schiff-base ligand 4-((E)-(3-bromo phenyl)diazenyl)-2-((E)-(thiazol-2-ylimino) methylphenol HL1 using the coupling of diazonium salt of 3-bromoaniline with (E)-2-(thiazol-2-ylimino) methyl phenol. The new azo Schiff thiazol ligand and its chelate complexes were characterized by available spectra and analytical methods such as mass spectra, proton nuclear magnetic resonance (1H-NMR), infrared (IR) spectroscopy, ultraviolet-visible spectroscopy (UV-Vis), elemental analysis (CHN), molar conductivity and magnetic susceptibility measurements. Results showed that the ratio of metal: ligand was 1:2, and also showed that Co(Ⅱ), Ni(Ⅱ), and Cu(Ⅱ) chelate complexes had octahedral geometry, while Zn(Ⅱ), Cd(Ⅱ) and Hg(Ⅱ), had tetrahedral geometry. The ligand with its complexes was tested in vintor against the sensitive organisms, including Staphylococcus aureus (gram positive) and Pseudomonas aeruginosa (gram negative). The study showed that the prepared metal complexes had more biological affectivity than the ligands themselves.

Keywords

Azo-Schiff thiazolChelate complexesBiological study

References

[1]

R. Carballo, J.S. Casas, and E.G. Arcia-Martinez, 2,5-Dihydro-3,4-dimethyl-5-oxo-1H-pyrazole-1-carbothioamide. Acta Crystallographica Section E: Structure Reports Online, 2002, 58(7): 787-789.
Crossref Google Scholar
[2]

A.A.S. Al-Hamdani, S.A. Shaker, Synthesis, characterization, structural studies and biological activity of a new Schiff base-azo ligand and its complexation with selected metal ions. Oriental Journal of Chemistry, 2011, 27(3): 835-845.
Google Scholar
[3]

A.N. Alaghaz, Y.A. Ammar, Synthesis, spectral characterization, thermal analysis, molecular modeling and antimicrobial activity of new potentially N2O2 azo-dye Schiff base complexes. Journal of Molecular Structure, 2014, 1074: 359-375.
Crossref Google Scholar
[4]

H. Naeimi, K. Rabiei, and F. Salimi, Efficient and facile synthesis and characterization of novel Schiff bases and their complexes with transition metal ions. Dyes and Pigments, 2007, 75(2): 294-297.
Crossref Google Scholar
[5]

G.M. Malik, S.K. Zadafiya, Thaizole based disperse dyes and their dyeing application on polyester fiber and their antimicrobial activity. Chem. Sin., 2010, 1: 15-21.
Google Scholar
[6]

E. Erdem, E.Y. Sari, R. Kilicarslan, et al., Synthesis and characterization of azo-linked Schiff bases and their nickel (Ⅱ), copper (Ⅱ), and zinc (Ⅱ) complexes. Transition Metal Chemistry, 2009, 34(2): 167-174.
Crossref Google Scholar
[7]

B.T. Thaker, J.B. Kanojiya, and R.S. Tandel, Effects of different terminal substituents on the mesomorphic behavior of some azo-Schiff base and azo-ester-based liquid crystals. Molecular Crystals and Liquid Crystals, 2010, 528(1): 120-137.
Crossref Google Scholar
[8]

N. Raman, J.D. Raja, Synthesis, structural characterization and antibacterial studies of some biosensitive mixed ligand copper(Ⅱ) complexes. Indian Jouranol of Chemistry, 2007, 46A: 1612.
Google Scholar
[9]

N.G. El-Kholy, Synthesis, Spectroscopic characterization, antimicrobial, antitumor properties of new 4-amino-2,3 dimethyl-1-phenyl-3-pyrazolone-5-one (antipyrine) Schiff bases and its transition metal complexes. Journal of American Science, 2017, 13(2): 132-145.
Google Scholar
[10]

I. Karim, A Aoun, and A.H. Khafagy, Preparation, characterization and biological study of new azo-oxime ligand and some of its metal complexes. Kufa Journal for Chemistry, 2018, 2(3).
Google Scholar
[11]

M.A. Neelakantan, M. Esakkiammai, S.S. Mariappan, et al., Synthesis, characterization and biocidal activities of some schiff base metal complexes. Indian Journal of Pharmaceutical Sciences, 2010, 72(2): 216.
Crossref Google Scholar
[12]

B. Revathi, Potentially useful to NLO materials: 4-chloro-3-(trifluoromethyl) aniline, 4-bromo-3-(trifluoromethyl) aniline and 4-fluoro-3-(trifluoromethyl) aniline are combined experimental and theoretical vibrational analysis. Journal of Molecular Structure, 2017, 1141: 81-92.
Crossref Google Scholar
[13]

A.S. Shawali, M.A. Abdaliah, Substituent effects on azo coupling of indoles. Canadian Journal of Chemistry, 1993, 71(12): 2144-2149.
Crossref Google Scholar
[14]

S. Sarkar, S. Biswas, et al., An attempt towards coordination supramolecularity from Mn(Ⅱ), Ni(Ⅱ) and Cd(Ⅱ) with a new hexadentate[N4O2] symmetrical Schiff base ligand: Syntheses, crystal structures, electrical conductivity and optical properties. Polyhedron, 2008, 27(16): 3359-3370.
Crossref Google Scholar
[15]

C. Spinu, A. Kriza, Co(Ⅱ), Ni(Ⅱ) and Cu(Ⅱ) complexes of bidentate Schiff bases. Acta Chimica Slovenica, 2000, 47(2): 179-186.
Google Scholar
[16]

M. Kurtoğlu, S.A. Baydemır, Studies on mononuclear transition metal chelates derived from a novel (E, E)-dioxime: Synthesis, characterization and biological activity. Journal of Coordination Chemistry, 2007, 60(6): 655-665.
Crossref Google Scholar
[17]

M. Bal, G. Ceyhan, Synthesis and X-ray powder diffraction, electrochemical, and genotoxic properties of a new azo-Schiff base and its metal complexes. Turkish Journal of Chemistry, 2014, 38(2): 222-241.
Crossref Google Scholar
[18]

O.A. El-Gammal, M.M. Bekheit, and S.A. El-Brashy, Synthesis, characterization and in vitro antimicrobial studies of Co(Ⅱ), Ni(Ⅱ) and Cu(Ⅱ) complexes derived from macrocyclic compartmental ligand. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2015, 137: 207-219.
Crossref Google Scholar
[19]

N. Kimura, Observation of reciprocal induced CD between Colloidal gold nanoparticles and chiral Schiff base Zn(Ⅱ) complexes with parallel dipole moments. Journal of Chemistry and Chemical Engineering, 2013, 7(5): 390.
Google Scholar
[20]

M.S. Nair, R.S. Joseyphus, Synthesis and characterization of Co(Ⅱ), Ni(Ⅱ), Cu(Ⅱ) and Zn(Ⅱ) complexes of tridentate Schiff base derived from vanillin and DL-α-aminobutyric acid. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2008, 70(4): 749-753.
Crossref Google Scholar
[21]
S.E. Al-Mukhtar, I.A. Mustafa, Inorganic and coordination chemistry. Mosul University, Iraq, 1988.
[22]

A.H. Al-Khafagy, Synthesis, characterization and biological study of some new metal-azo chelate complexes. J. Chem. Pharm. Res, 2016, 8(8): 296-302.
Google Scholar
[23]

R.S. Joseyphus, M.S. Nair, Antibacterial and antifungal studies on some schiff base complexes of zinc(Ⅱ). Mycobiology, 2008, 36(2): 93-98.
Crossref Google Scholar
[24]

T.D. Thangadurai, K. Natarajan, Mixed ligand complexes of ruthenium (Ⅱ) containing α, β-unsaturated-β-ketoaminesand their antibacterial activity. Transition Metal Chemistry, 2001, 26(4-5): 500-504.
Crossref Google Scholar
[25]

Z.J. Mohammed, A.H. AL-Khafagy, and A.M. Ali, Preparation, characterization and biological study of heterocyclic azo-schiff base compound and some of its metal complexes. Int. J. Currant, 2013, 5(12) : 3705-3710.
Google Scholar
Nano Biomedicine and Engineering
Volume 10 Issue 4,
December 2018
Pages 369-378
DOI: 10.5101/nbe.v10i4.p369-378
Cite this article:
Mahdi ES, Al-Sa'edi RTM. Preparation and Antibacterial Activity of New Azo-Schiff Thiazol Ligand and Some of its Metal Complexes. Nano Biomedicine and Engineering, 2018, 10(4): 369-378. https://doi.org/10.5101/nbe.v10i4.p369-378

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Received: 07 July 2018
Accepted: 23 July 2018
Published: 19 November 2018
© Eateman Salah Mahdi, Raheem Tahir Mahdi AlSa›edi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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