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Nano Biomedicine and Engineering 2019, 11(1): 18-27 https://doi.org/10.5101/nbe.v11i1.p18-27
Research Article | Open Access | Issue | Published: 22 February 2019

Polyethylene Glycol-Functionalized Magnetic (Fe3O4) Nanoparticles: A Novel DNA-Mediated Antibacterial Agent

Show Author's Information Majid Sakhi Jabir1( ),  Uday Muhsen Nayef2( ),  Kadhim Waleed Kamel Abdul2
Division of Biotechnology, Department of Applied Science, University of Technology, Baghdad, Iraq
Division of Applied Physics, Department of Applied Science, University of Technology, Baghdad, Iraq
Keywords:
Hydrothermal synthesis, Antibacterial activity, Fe3O4-PEG, DNA damage
Cite this article:
Jabir MS, Nayef UM, Abdul KWK. Polyethylene Glycol-Functionalized Magnetic (Fe3O4) Nanoparticles: A Novel DNA-Mediated Antibacterial Agent. Nano Biomedicine and Engineering, 2019, 11(1): 18-27. https://doi.org/10.5101/nbe.v11i1.p18-27
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Abstract Full text About this article

The Fe3O4-PEG magnetic nanoparticles (NPs) were prepared by hydrothermal method at different concentrations (FeCl3·6H2O 0.75 mg/mL and FeCl3·6H2O 1.5 mg/mL) and subsequently surface-functionalized coating with polyethylene glycol (PEG), the successful coating of PEG molecules on the surface of Fe3O4. These magnetic NPs exhibited good dispersibility and dissolvability in physiological condition. The obtained magnetic nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, thermogravimetry (TG) and vibrating sample magnetometer (VSM). The antibacterial activity of Fe3O4-PEG magnetic nanoparticles (MNPs) was studied against two bacterial strains: Gram-positive Staphylococcus and Gram-negative Escherichia coli aureus. The modified MNPs had a significant effect is more on S. aureus and less on E. coli. The results showed that polyethylene glycol-functionalized magnetic (Fe3O4) NPs as a novel DNA-mediated antibacterial agent.


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About this article

Polyethylene Glycol-Functionalized Magnetic (Fe3O4) Nanoparticles: A Novel DNA-Mediated Antibacterial Agent

Show Author's information Majid Sakhi Jabir1( ), Uday Muhsen Nayef2( ), Kadhim Waleed Kamel Abdul2
Division of Biotechnology, Department of Applied Science, University of Technology, Baghdad, Iraq
Division of Applied Physics, Department of Applied Science, University of Technology, Baghdad, Iraq

Abstract

The Fe3O4-PEG magnetic nanoparticles (NPs) were prepared by hydrothermal method at different concentrations (FeCl3·6H2O 0.75 mg/mL and FeCl3·6H2O 1.5 mg/mL) and subsequently surface-functionalized coating with polyethylene glycol (PEG), the successful coating of PEG molecules on the surface of Fe3O4. These magnetic NPs exhibited good dispersibility and dissolvability in physiological condition. The obtained magnetic nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, thermogravimetry (TG) and vibrating sample magnetometer (VSM). The antibacterial activity of Fe3O4-PEG magnetic nanoparticles (MNPs) was studied against two bacterial strains: Gram-positive Staphylococcus and Gram-negative Escherichia coli aureus. The modified MNPs had a significant effect is more on S. aureus and less on E. coli. The results showed that polyethylene glycol-functionalized magnetic (Fe3O4) NPs as a novel DNA-mediated antibacterial agent.

Keywords: Hydrothermal synthesis, Antibacterial activity, Fe3O4-PEG, DNA damage

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Publication history

Received: 14 May 2018
Accepted: 25 September 2018
Published: 22 February 2019
Issue date: March 2019

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© Majid Sakhi Jabir, Uday Muhsen Nayef, and Waleed Kamel Abdul Kadhim.

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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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