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Research Article | Open Access

Preparation and Characterization of Nanoparticulate Drug Delivery System for Naproxen Sodium Using Various Desolvating Agents

RBVRR Women's College of Pharmacy, Barkatpura, Hyderabad, India
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Abstract

Naproxen sodium is a non-steroidal anti-inflammatory agent used for the treatment of autoimmune disorders to relieve pain and inflammation. In the present study, naproxen sodium nanoparticles were prepared by desolvation technique using various desolvating agents (butanol and combinations of acetonitrile and butanol), and two methods (continuous addition method and intermittent addition method) were adapted to decide the best desolvating agent. Obtained formulations were characterized and evaluated. The combination of acetonitrile and butanol as desolvating agent was giving good and promising results with good stability -40.7 mV and least mean particle diameter of 437.7 nm. From the results it was concluded that intermittent addition was the better method than continuous addition method for preparing naproxen sodium nanoparticles. The drug release was sustained till 12 h with 96.92% for nanoparticles prepared by intermittent addition method following zero order release with non- fickian diffusion mechanism.

Keywords

DesolvationBovine serum albuminCross linking agentButanolSEM

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Nano Biomedicine and Engineering
Volume 11 Issue 3,
September 2019
Pages 254-263
DOI: 10.5101/nbe.v11i3.p254-263
Cite this article:
Syed H, Sailaja AK. Preparation and Characterization of Nanoparticulate Drug Delivery System for Naproxen Sodium Using Various Desolvating Agents. Nano Biomedicine and Engineering, 2019, 11(3): 254-263. https://doi.org/10.5101/nbe.v11i3.p254-263

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Received: 21 June 2019
Accepted: 16 August 2019
Published: 16 August 2019
© Huda Syed, Abbaraju Krishna Sailaja.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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