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Research Article | Open Access

Design of Curcumin-Loaded Electrospun Polyhydroxybutyrate Mat as a Wound Healing Material

Reyhaneh Ghavami L1, Esmaeil Biazar1( ), Arezoo Sodagar Taleghani2, Saeed Heidari Keshel3
Department of Biomaterials Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran
Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Abstract

Nanotechnology and tissue engineering have accelerated wound healing. Polyhydroxyalkanoates, with suitable physical, biological and mechanical properties, can be considered as a good candidate in tissue repair and regeneration. In this study, nanofibrous mats of polyhydroxybutyrate (PHB) containing curcumin as a wound healing agent, were designed by electrospinning method. The samples were evaluated by microscopic and mechanical analyses, cell assays and microbial tests. The results of microscopic images showed that the diameter of fibers increased with the increase in the curcumin concentration. The elongation and elasticity modulus of nanofibers increased and decreased respectively, with the increase in the amount of curcumin. Drug release study indicated that increasing the curcumin concentration into nanofibers accelerated rate of drug release. Cytotoxicity results of nanofibrous samples with lower curcumin showed better biocompatibility. The strongest antibacterial activity was shown by the sample with 3% curcumin. In addition, Curcumin-loaded nanofibrous PHB can be potential candidates for wound healing.

Keywords

CurcuminControlled releaseCytotoxicity studyPhysical and mechanical propertiesPolyhydroxybutyrate (PHB) nanofiber

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Nano Biomedicine and Engineering
Volume 12 Issue 1,
March 2020
Pages 14-20
DOI: 10.5101/nbe.v12i1.p14-20
Cite this article:
Ghavami L R, Biazar E, Taleghani AS, et al. Design of Curcumin-Loaded Electrospun Polyhydroxybutyrate Mat as a Wound Healing Material. Nano Biomedicine and Engineering, 2020, 12(1): 14-20. https://doi.org/10.5101/nbe.v12i1.p14-20

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Received: 16 October 2019
Accepted: 07 February 2020
Published: 13 February 2020
© Reyhaneh Ghavami L, Esmaeil Biazar, Arezoo Sodagar Taleghani, and Saeed Heidari Keshel,.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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