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Research Article | Open Access

Synthesis, Characterization, Spectroscopic and Biological Studies of Zn(Ⅱ), Mn(Ⅱ) and Fe(Ⅱ) Theophylline Complexes in Nanoscale

Ahmad Hussein Ismail1( ), Hassanain Kamil Al-Bairmani1, Zainab Sabri Abbas1, Ahmed Mahdi Rheima2( )
Mustansiriyah University, College of Science, Department of Chemistry, Iraq
Department of Chemistry, College of Science, Wasit University, Kut, Iraq
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Abstract

Three nanocomplexes of Zn(Ⅱ), Mn(Ⅱ), Fe(Ⅱ) with theophylline were synthesized by ultrasonic sonication method. Melting point, molar conductivity, solubility, flame atomic absorption, Fourier-transform infrared spectroscopy (FTIR), ultraviolet-visible (UV-vis) spectroscopy and C/H/N elemental analyses were used to investigate and suggest the structure of the nanocomplexes. Size and morphology of the nanocomplexes were measurement by transmission electron microscopy (TEM), ranging from 6-22 nm. Efficacy of the nanocomplexes synthesized was examined against four types of bacterial strains: Staphylococcus aureus, Bacillus subtilis (Gram-positive bacteria), Klebsiella pneumonia and Escherichia coli (Gram-negative bacteria). The results showed that all nanocomplexes had very high susceptibility to inhibit bacterial growth, as indicated by their inhibition zones between 98% and 100%.

Keywords

Nanoscale complexesTheophyllineUltrasonic methodbacterial strainsTEM

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Nano Biomedicine and Engineering
Volume 12 Issue 3,
September 2020
Pages 253-261
DOI: 10.5101/nbe.v12i3.p253-261
Cite this article:
Ismail AH, Al-Bairmani HK, Abbas ZS, et al. Synthesis, Characterization, Spectroscopic and Biological Studies of Zn(Ⅱ), Mn(Ⅱ) and Fe(Ⅱ) Theophylline Complexes in Nanoscale. Nano Biomedicine and Engineering, 2020, 12(3): 253-261. https://doi.org/10.5101/nbe.v12i3.p253-261

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Received: 05 February 2020
Accepted: 03 July 2020
Published: 18 September 2020
© Ahmad Hussein Ismail, Hassanain Kamil Al-Bairmani, Zainab Sabri Abbas, and Ahmed Mahdi Rheima.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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