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Research Article | Open Access

Multifunctional Fluorocarbon-conjugated Nano-particles of Varied Morphologies to Enhance Diagnostic Effects in Breast Cancer

Melissa Ronni Laughter1,+, Anna Laura Nelson1,+, Maria Bortot1, Brisa Pena1, Bolin Liu2, Daewon Park1( )
Department of Bioengineering, University of Colorado Denver Anschutz Medical Campus, Aurora, CO 80045 USA
Department of Genetics, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112 USA

+ These authors contributed equally to this work.

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Abstract

A multifunctional trastuzumab-nanoparticle-fluorocarbon system was developed to maximize the diagnostic effects in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. The mesoporous silica nanoparticle shape (e.g. amorphous, spherical, and tubular) was altered to optimize the ultrasound contrast potential. Fluorocarbon conjugated mesoporous silica nanoparticles produced higher mean pixel intensities. At lower non-toxic concentrations, tubular shaped nanoparticles produced a higher mean pixel intensity compared to amorphous and spherical particles. All systems displayed a clear binding preference towards HER2-positive breast cancer cells. Increased incubation times and conjugation of fluorocarbon to mesoporous nanoparticles increased binding preference to HER2-positive breast cancer cells. The highest binding affinity was seen with tubular shaped nanoparticles as compared to amorphous and spherical particles. The trastuzumab-nanoparticle-fluorocarbon system of each morphology displayed functionality of enhancing contrast in ultrasound.

Keywords

Breast cancerContrast agentUltrasoundMesoporous silica nanoparticlesDiagnostic

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Nano Biomedicine and Engineering
Volume 13 Issue 1,
March 2021
Pages 52-61
DOI: 10.5101/nbe.v13i1.p52-61
Cite this article:
Laughter MR, Nelson AL, Bortot M, et al. Multifunctional Fluorocarbon-conjugated Nano-particles of Varied Morphologies to Enhance Diagnostic Effects in Breast Cancer. Nano Biomedicine and Engineering, 2021, 13(1): 52-61. https://doi.org/10.5101/nbe.v13i1.p52-61

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Received: 10 September 2017
Accepted: 20 September 2017
Published: 27 September 2017
© Melissa Ronni Laughter, Anna Laura Nelson, Maria Bortot, Brisa Pena, Bolin Liu, and Daewon Park.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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