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Research Article | Open Access

Impact of Copper Oxide and Selenium Nanoparticles on the Activities of Myeloperoxidase and Gamma-Glutamyl Transferase Related Oxidative Stress of Myocardial Infarction Patients

Nada Ahmed1, Dhia Hussain1, Sura Abdulsattar2( )
Department of Chemistry, College of Science, Mustansiriyah University, Iraq
Department of Chemistry and Biochemistry, College of Medicine, Mustansiriyah University, Iraq
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Abstract

Nanomedicine has tremendous prospects for the improvement of the diagnosis and treatment of human diseases. Nanotechnology has the potential to revolutionize a wide array of tools in biotechnology so that they are more personalized, portable, cheaper, safer and easier to administer. The present study aims to study the impact of copper oxide and selenium nanoparticles on the oxidative stress in sera of myocardial infraction patients through the synthesis and characterization of copper oxide and selenium nanoparticles, and the evaluation of the status of oxidative stress in sera of myocardial infraction patients through measurement of the activities of myeloperoxidase and gamma-glutamyl transferase in the presence and absence of nanoparticles in sera of myocardial infraction patients. Cupric oxide nanoparticles and selenium nanoparticles have been prepared by a chemical method and by laser ablation method respectively, and have been characterized. The result indicated that copper oxide (grain shapes with the average size 30 - 80 nm) and selenium nanoparticles (rod-shaped structures with the average size 70 - 90 nm) had an inhibition effects on myeloperoxidase and gamma-glutamyl transferase activities, and as a result had an inhibition effects on oxidative stress.

Keywords

Copper oxide nanoparticlesSelenium nanoparticlesMyeloperoxidaseGamma-glutamyl transferaseMyocardial infarction

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Nano Biomedicine and Engineering
Volume 13 Issue 2,
June 2021
Pages 165-171
DOI: 10.5101/nbe.v13i2.p165-171
Cite this article:
Ahmed N, Hussain D, Abdulsattar S. Impact of Copper Oxide and Selenium Nanoparticles on the Activities of Myeloperoxidase and Gamma-Glutamyl Transferase Related Oxidative Stress of Myocardial Infarction Patients. Nano Biomedicine and Engineering, 2021, 13(2): 165-171. https://doi.org/10.5101/nbe.v13i2.p165-171

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Received: 25 July 2020
Accepted: 22 March 2021
Published: 06 May 2021
© Nada Ahmed, Dhia Hussain, and Sura Abdulsattar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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