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Letter to the Editor | Open Access

Development of Exhaled Breath Diagnosis Sensors for Rapid Identification of COVID-19 Patients

Cuili Xue1, Amin Zhang1, Yunsheng Chen2, Hui Liang3, Jing Tian3, Jingpu Zhang4, Chen Zhou3, Jian Ni1,3, Han Jin1,3( ), Daxiang Cui1,3( )
Institute of Nano Biomedicine and Engineering, Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, School of Medicine Shanghai Jiao Tong University, 639 Zhizaoju Road, Shanghai 200011, China
National Engineering Research Center for Nanotechnology, 28 Jiangchuan Road, Shanghai 200241, China
Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jinshan District, Shanghai 201508, China
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Abstract

The novel coronavirus pneumonia, a global pandemic disease named as coronavirus disease 2019, has caused enormous losses on the health and economies of people all over the world, while there is still a lack of quick and sensitive diagnostic method and effective therapy. Developing rapid diagnostic method for coronavirus disease 2019 has become exceptional urgent. Herein we report a rapid diagnostic method for the novel coronavirus through monitoring the volatile biomarkers in human exhaled breath. The breath volatile biomarkers are derived from the metabolism of novel coronavirus, including acetoin, 2,4,6-trimethylpyridine, 3-methyl tridecane, tetradecane, isooctyl alcohol, pentadecane, hexadecane, 1-methylene-1H-indene. By comparing the types and concentrations of the volatile biomarkers in human exhaled breath combined with SERS sensor, we could distinguish between the healthy person and the patients with coronavirus disease 2019. This work confirms that various volatile organic compounds metabolized by novel coronavirus can be employed for rapidly screening of patients with coronavirus disease 2019, and has broad application prospects in the prevention and control of the epidemic.

Keywords

Coronavirus disease 2019Volatile organic compoundsExhaled breath diagnosisSensor

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Nano Biomedicine and Engineering
Volume 13 Issue 3,
September 2021
Pages 225-228
DOI: 10.5101/nbe.v13i3.p225-228
Cite this article:
Xue C, Zhang A, Chen Y, et al. Development of Exhaled Breath Diagnosis Sensors for Rapid Identification of COVID-19 Patients. Nano Biomedicine and Engineering, 2021, 13(3): 225-228. https://doi.org/10.5101/nbe.v13i3.p225-228

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Received: 23 February 2021
Accepted: 05 August 2021
Published: 06 August 2021
© Cuili Xue, Amin Zhang, Yunsheng Chen, Hui Liang, Jing Tian, Jingpu Zhang, Chen Zhou, Jian Ni, Han Jin, and Daxiang Cui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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