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Research Article | Open Access

Inhibition Effect ofCopper (Ⅱ) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease

Zainab Sabri Abbas1, Ahmad Hussein Ismail2, Hassanain Kamil Al-Bairmani2, Ahmed Mahdi Rheima3,4( ), Ameer Radhi Sultan5, Srwa Hashim Mohammed6
Kut University College, Dentistry Department, Al-Kut, Wasit, Iraq, 52001
Mustansiriyah University, College of Science, Department of Chemistry. Iraq
Wasit University, College of Science, Department of Chemistry, Kut, Iraq
College of technical engineering, The Islamic University, Najaf, Iraq
Department of Chemistry Lab, Al-lmamine Al-Kadhumain Medical City Hospital, Baghdad, Iraq
Garmian University, College of Education, Department of Chemistry. Kalar, Iraq
Show Author Information

Abstract

Copper (Ⅱ) theophylline [Cu(THP)2(H2O)4] complex in nanoscale has synthesized by ultrasonic sonication method. This method was used in the development of smaller, dispersed, and unaggregated nanoparticles (NPs). The structure of nanocomplex was described and suggested by the molar conductance, Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), solubility, atomic fire absorption, and C.H.N. elemental analysis as octahedral geometry. The size and morphology of nanocomplex measured by transmission electron microscopy (TEM) were 20 nm. The nanocomplex was studied on phosphodiesterase enzyme activity in human serum of Iraqi patient?s asthma disease. The results showed a highly significant (p < 0.01) increase in the serum levels of phosphodiesterase enzyme activity in asthma patients (mean = 14.939 ± 3.021 ng/mL) compared with a control group (mean = 9.974 ± 2.032 ng/mL). The result also showed a highly significant (p < 0.01) decrease in the serum levels of phosphodiesterase activity in patients of asthma disease with theophylline (mean = 11.253 ± 2.479 ng/mL) compared to serum patients without nano and control groups. It is vital that the result showed a highly significant (p < 0.01) decrease in the serum levels of phosphodiesterase activity in patients of asthma disease with copper nano complex (mean = 9.563 ± 2.082 ng/mL) compared in patients of asthma disease with and without theophylline. As for comparing asthma disease with copper nano complex and control group, the result showed there was no significant effect (p > 0.05).

Keywords

NanocomplexAsthmaPhosphodiesterase (PDE)TheophyllineUltrasonic sonication method

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Nano Biomedicine and Engineering
Volume 13 Issue 4,
December 2021
Pages 364-371
DOI: 10.5101/nbe.v13i4.p364-371
Cite this article:
Abbas ZS, Ismail AH, Al-Bairmani HK, et al. Inhibition Effect ofCopper (Ⅱ) Theophylline Nanocomplex on Phosphodiesterase (PDE) Enzyme Activity in Human Serum of Iraqi Patients with Asthma Disease. Nano Biomedicine and Engineering, 2021, 13(4): 364-371. https://doi.org/10.5101/nbe.v13i4.p364-371

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Received: 03 August 2020
Accepted: 05 August 2021
Published: 02 November 2021
© Zainab Sabri Abbas, Ahmad Hussein Ismail, Hassanain Kamil Al-Bairmani, Ahmed Mahdi Rheima, Ameer Radhi Sultan, and Srwa Hashim Mohammed.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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