Capsaicin Nanoparticles as Therapeutic Agents against Gliomas

Evelin Martínez-Benavidez; Inocencio Higuera-Ciapara; Sara Elisa Herrera-Rodríguez; Ofelia Yadira Lugo-Melchor; FranciscoMartín Goycoolea; FranciscoJavier Guerrero Jazo

doi:10.5101/nbe.v13i4.p433-445

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Review | Open Access

Capsaicin Nanoparticles as Therapeutic Agents against Gliomas

Evelin Martínez-Benavidez^¹, Inocencio Higuera-Ciapara^², Sara Elisa Herrera-Rodríguez^³, Ofelia Yadira Lugo-Melchor^¹(

), FranciscoMartín Goycoolea^⁴, FranciscoJavier Guerrero Jazo^⁵

Unidad de Servicios Analíticos y Metrológicos, Centro de Investigación y Asistencia en Tecnología y Dise?o del Estado de Jalisco, A. C. (CIATEJ). Guadalajara 44270, Jalisco, México

Universidad Anáhuac Mayab, S.C. Mérida 97302, Yucatán, México

Unidad Sureste, CIATEJ. Mérida 97302, Yucatán, México

School of Food Science and Nutrition. University of Leeds. Woodhouse Ln, Leeds LS2 9JT. UK

Departamento de Neurocirugía, Hospital Civil "Dr. Juan I. Menchaca". Guadalajara, 44340, Jalisco, México

Show Author Information

Abstract

Capsaicin is an alkaloid molecule with outstanding biological activity. Several reports have shown that capsaicin exerts significant antitumoral effects in several cancer cell lines, including gliomas. However, its application has been very limited due to its hydrophobicity, low affinity, and short life span. Gliomas are a heterogeneous group of brain malignant tumors with increasing prevalence worldwide. Standard therapy against these tumors generally includes resection by surgery, radiation, and chemotherapy or their combination. However, elicitation of tumor resistance to chemical or radiation treatments remains one of the main challenges to be resolved, particularly in the case of glioblastomas. Nanotechnology is an innovative approach to the treatment of Central Nervous System diseases and especially to gliomas treatment. Indeed, the use of nanotherapeutic formulations offers several advantages over the conventional methods of drug delivery therapy. In this review, we analyzed the current literature regarding the development of capsaicin-loaded nanoparticles as a promising approach for the treatment of malignant brain tumors.

Keywords

Drug delivery Glioblastoma Nanoencapsulation Capsaicin

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Nano Biomedicine and Engineering

Volume 13 Issue 4,
December 2021

Pages 433-445

DOI: 10.5101/nbe.v13i4.p433-445

Cite this article:

Martínez-Benavidez E, Higuera-Ciapara I, Elisa Herrera-Rodríguez S, et al. Capsaicin Nanoparticles as Therapeutic Agents against Gliomas. Nano Biomedicine and Engineering, 2021, 13(4): 433-445. https://doi.org/10.5101/nbe.v13i4.p433-445

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Received: 03 November 2020

Accepted: 02 December 2021

Published: 16 December 2022

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.