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Article | Open Access

The Study on Electrochemical Behaviors of the Interactions between Daunorubicin Hydrochloride and BSA

Jie Liu( ), Bo Zhang
Taiyuan City Centre Hospital, Taiyuan, 030009
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Abstract

The Electrochemical behaviors of Daunorubicin hydrochloride, and the interactions between Daunorubicin hydrochloride and BSA, were studied in this paper, with Linear sweep voltammetry and Cyclic voltammety methods. The results showed that, there was a reductive peak at E=-0.66V in the Linear sweep voltammetry of Daunorubicin hydrochloride, on condition of 0.1 mol·L-1Na2SO4, pH 8.5B-R buffer solution. After BSA was introduced, the system peak current reduced. There was a maximal system peak current Δip″, when the concentration of Daunorubicin hydrochloride was 5.0×10-5 mol·L-1. At the range of 5.0×10-8 mol·L-1-1.0×10-4 mol·L-1 of the concentration of BSA, it existed a good linear relation between the reduced valve of the peak current of Daunorubicin hydrochloride and the concentration of BSA. This method can be used in the detection of the concentration of BSA.

Keywords

Bovine serum albuminDaunorubicin hydrochlorideelectrochemical behaviorsLinear sweep voltammetryCyclic voltammety

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Nano Biomedicine and Engineering
Volume 2 Issue 2,
June 2010
Pages 138-142
DOI: 10.5101/nbe.v2i2.p138-142
Cite this article:
Liu J, Zhang B. The Study on Electrochemical Behaviors of the Interactions between Daunorubicin Hydrochloride and BSA. Nano Biomedicine and Engineering, 2010, 2(2): 138-142. https://doi.org/10.5101/nbe.v2i2.p138-142

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Received: 10 June 2010
Accepted: 06 July 2010
Published: 09 July 2010
© 2010 J. Liu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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