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Article | Open Access

Intervention Effects of Jinkuishenqiwan Pills on the Kidney-yang Deficiency in Rats

Heliang Liu1,+, Weihong Zhang2,+, Jinshan Zhang3, Wenyong Wang4, Jun Qin1, Bo Yang1, Jianlin Yuan1, Changsheng Chen5( )
Department of Urology, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China
Department of Foreign Language, Fourth Military Medical University, Xi’an 710032, China
Department of Human Anatomy and Histology & Embryology, Fourth Military Medical University, Xi’an 710032, China
Department of Pathology and Pathophysiology, Fourth Military Medical University, Xi’an 710032, China
Department of Health Statistics, Faculty of Preventive Medicine, Fourth Military Medical University, Xi’an 710032, China

+ Heliang Liu and Weihong Zhang contributed equally to this paper.

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Abstract

With the aim of investigating the ability and possible mechanism of Chinese medicine Jinkuishenqiwan pills to inhibit the spermatgoenic arrest infertile, 100 mature male rats were randomly divided into five groups: normal control group, model group, test group treated with high dosage of Jinkuishenqiwan pills, test group treated with middle dosage of Jinkuishenqiwan pills, and test group treated with low dosage of Jinkuishenqiwan pills. Except the normal group, the other four groups were made into model of kidneyyang deficiency by injecting hydrocortisone. Simultaneously, the treatment of Jinkuishenqiwan pills was also irrigated into the stomachs of the three treated groups. After 30 days，the concentration of testosterone, the sperm density and the motility rate of sperm were examined, the microstructure of testicle was observed by optical microscope. Results showed that Jinkuishenqiwan pills can inhibit the spermatgoenic arrest infertile, there exists statistical difference between test group and the model group (P<0.05). In conclusion: Chinese medicine Jinkuishenqiwan pills may have a certain therapeutic effects on the rats with kidney-yang deficiency.

Keywords

JinkuishenqiwanModel of Kidney-Yang deficiencySpermatogenic arrestTestosterone

References

1
Zhong Guo Yao Dian Committee. P. R. China. Beijing: Chemistry industry press, 2000; 105.
2

Liu, CX. Research and Development of Nanopharmaceuticals in China. Nano Biomed Eng 2009; 1(1): 1-12. doi: 10.5101/nbe.v1i1.p1-12
Crossref Google Scholar
3

Tang, ZY; Ling, GW. Advances in studies on nano-Chinese materia medica. Chinese Traditional and Herbal Drugs 2007; 38: 627-629.
Google Scholar
4

Keahler, T. Nanotechnology: basic concepts and definitions. Clin Chem 1994; 40: 1797-1799.
Crossref Google Scholar
5

Yang, XL; Xu, HB; Wu, JZ. Application of nanotechnology in the research of traditional Chinese medicine. J Huazhong Univ Sci Technol, 2000; 28: 104-105.
Google Scholar
6
Li, YB, editor-in-chief. Nano biomedicine materials. Chemistry Industry press. 2003; 103-231.
7

Liu, HL; Chen, CS; Wang, WY. Intervention effect of Jinkuishenqiwan on the kidney-yang deficiency in rats. J Fourth Mil Med Univ, 2009; 30: 2140-2142.
Google Scholar
8

Liu, CS; He, QH; Huang, JS. Effect of Tiancan Zhuangyang decoction on reproduction function in male mice with kidney yang deficiency. Journal of Traditional Chinese Medicine University of Hunan, 2008; 28(3): 26-28.
Google Scholar
9

Chen, YH; Ouyang, YQ; Sun, Qi. A primary discussion of diagnosis indexes choosing in standardization study of animal model with kidney-yang deficiency. Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 2003; 9(10): 26-30.
Google Scholar
10

He, QH; Zhen, YC; Li, X. Clinical observation of Jinkui Shenqi Wan in treating male infertility. Tianjin Journal of Traditional Chinese Medicine, 2003; 20(1): 18-19.
Google Scholar
Nano Biomedicine and Engineering
Volume 2 Issue 3,
September 2010
Pages 189-192
DOI: 10.5101/nbe.v2i3.p189-192
Cite this article:
Liu H, Zhang W, Zhang J, et al. Intervention Effects of Jinkuishenqiwan Pills on the Kidney-yang Deficiency in Rats. Nano Biomedicine and Engineering, 2010, 2(3): 189-192. https://doi.org/10.5101/nbe.v2i3.p189-192

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Received: 25 July 2010
Accepted: 18 September 2010
Published: 10 October 2010
© 2010 H. Liu et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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