AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Nano Biomedicine and Engineering Article
PDF (751.7 KB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Article | Open Access

Functionalized Multiwalled Carbon Nanotubesanticancer Drug Carriers: Synthesis, Targeting Ability and Antitumor activity

Zhong Tian, Yinfeng Shi, Min Yin, Hebei Shen, Nengqin Jia( )
Department of Chemistry, College of Life and Environmental Science, Shanghai Normal University, Shanghai 200234, China
Show Author Information

Abstract

A novel functionalized multiwalled carbon nanotubes(f-MWNTs)-anticancer drug carriers were prepared by modifying carbon nanotubes with polyethylenimine (PEI), folic acid and quantum dots for targeting and imaging cancer cells. The functionalized MWNTs exhibited good aqueous solubility, biocompatibility and high targeting ability. Water-insoluble anticancer drug Paclitaxel (PTX) were further loaded onto the f-MWNTs mainly through noncovalent π–π stacking interaction. In vitro cytotoxicity studies of f-MWNTs–PTX complexes using MTT assay exhibited a significant enhancement in the cytotoxic capability, suggesting these targeting drug carriers could facilitate intracellular delivery of anticancer drug and improve drug antitumor activity. Therefore, the highly versatile multifunctional carbon nanotubes could potentially be used for advanced drug delivery in biomedical fields.

Keywords

Quantum dotsDrug deliveryPaclitaxelFolic acidMultiwalled carbon nanotubes

References

1

You J, Hu FQ, Du YZ, Yuan H. Improved cytotoxicity of doxorubicin by enhancing its nuclear delivery mediated via nanosizedmicelles. Nanotechnology 2008; 9: 255103-255111. doi: 10.1088/0957-4484/19/25/255103
Crossref Google Scholar
2

Luo Y, Ziebell MR, Prestwich GD. A hyaluronic acid-Taxol antitumor bioconjugate targeted to cancer cells. Biomacromolecules 2000; 1: 208-218. doi: 10.1021/bm000283n
Crossref Google Scholar
3

Hood JD, Frausto R. Tumor regression by targeted gene delivery to the neovasculature. Science 2002; 296: 2404–2407. doi: 10.1126/science.1070200
Crossref Google Scholar
4

Ran S, Downes A, Thorpe PE. Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res 2002; 62: 6132–6140.
Google Scholar
5

Park JW, et al. Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery. Clin. Cancer Res 2002; 8: 1172– 1181.
Google Scholar
6

Pastorino F, Marimpietri D, Marimpietri D. Doxorubicin-loaded Fab fragments of antidisialoganglioside immunoliposomes selectively inhibit the growth and dissemination of human neuroblastoma in nude mice. Cancer Res 2003; 63: 86–92.
Google Scholar
7

Ishida T, Kirchmeier MJ, Moase EH, Zalipsky S, Allen TM.Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells. Biochim. Biophys Acta 2001; 1515: 144–158. doi: 10.1016/S0005-2736(01)00409-6
Crossref Google Scholar
8

Bhirde AA, Patel V, Gavard J, Zhang GF, Sousa AA, Masedunskas A, Leapman RD, Weigert R, Gutkind JS, Rusling JF. Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery. ACS Nano 2009; 3: 307–316. doi: 10.1021/nn800551s
Crossref Google Scholar
9

Singha R, Kim GJ. Nie S, Shin DM. Nanotechnology in cancer therapeutics: bioconjugated nanoparticles for drug delivery. Mol Cancer Ther 2006; 5: 1909–1917. doi: 10.1158/1535-7163.MCT-06-0141
Crossref Google Scholar
10

Allen T, Cullis P. Drug delivery systems: entering the mainstream. Science 2004; 303: 1818–1822. doi: 10.1126/science.1095833
Crossref Google Scholar
11

Moghimi SM, Hunter AC, Murray JC. Long-circulating and targetspecific nanoparticles: theory to practice. Pharmacol Rev 2001; 53: 283–318.
Google Scholar
12

Chen SH, Ji YX, Lian Q, Wen YL, Shen Hb, Jia NQ. Gold nanorods coated with multilayer polyelectrolyte as intracellular delivery vector of antisense oligonucleotides. Nano Biomed Eng 2010; 2(1): 15-23
Crossref Google Scholar
13

Ajayan PM. Nanotubes from carbon. Chem Rev 1999; 99: 1787–1800 doi: 10.1021/cr970102g
Crossref Google Scholar
14

Hersam MC. Progress towards monodisperse single-walled carbon nanotubes. Nat Nanotechnol 2008; 3:387–394. doi: 10.1038/nnano.2008.135
Crossref Google Scholar
15

Cui D, et al. Effects of CdSe/Zs quantum dots covered multi-walled carbon nanotubes on murine embryonic stem cells. Nano Biomed. Eng. 2010; 2(4): 236-244. doi: 10.5101/nbe.v2i4.p236-244
Crossref Google Scholar
16

Chen R, Zhang Y, Wang D, Dai H. Non-covalent sidewall functionalization of single-walled carbon nanotubes for protein immobilization. J Am Chem Soc 2001; 123(16): 3838–3839. doi: 10.1021/ja010172b
Crossref Google Scholar
17

Kam, NWS, Liu Z, Dai H. Functionalization of carbon nanotubes via cleavable disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. J Am Chem Soc 2005; 127(36): 12492–12493. doi: 10.1021/ja053962k
Crossref Google Scholar
18

Bianco A, Kostarelos K, Partidos CD, Prato M. Biomedical applications of functionalised carbon nanotubes. Chem Commun 2005; 5: 571–577. doi: 10.1039/b410943k
Crossref Google Scholar
19

Kam NWS, O’Connell M, Wisdom JA, Dai H. Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc Natl Acad Sci 2005; 102: 116 00–11605. doi: 10.1073/pnas.0502680102
Crossref Google Scholar
20

Kam NWS, Liu Z, Dai H. Functionalization of carbon nanotubes via cleavable Disulfide bonds for efficient intracellular delivery of siRNA and potent gene silencing. J Am Chem Soc 2005; 127: 1249 2-12493. doi: 10.1021/ja053962k
Crossref Google Scholar
21

Jia NQ, Lian Q, Shen HB, Wang C, Li XY, Yang ZN. Intracellular delivery of quantum dots tagged antisense oligodeoxynucleotides by functionalized multiwalled carbon nanotubes. Nano Lett 2007; 10: 2976-2980. doi: 10.1021/nl071114c
Crossref Google Scholar
22

You J, Li X, Cui FD, Du YZ, Yuan H, Hu FQ. Folate-conjugated polymer micelles for active targeting to cancer cells: preparation, in vitro evaluation of targeting ability and cytotoxicity. Nanotechnology 2008; 19: 045102(9pp).
Crossref Google Scholar
23

Luo Y, Ziebell MR, Prestwich GD. A hyaluronic acid-Taxol antitumor bioconjugate targeted to cancer cells. Biomacromolecules 2000; 1: 208-218. doi: 10.1021/bm000283n
Crossref Google Scholar
24

Grecory RE, Anne FD. Paclitaxel : A new antineoplastic agent for refractory ovarian cancer. Clin Pharm 1993; 12: 401-415.
Google Scholar
25

Kamaly N, Kalber T, Thanou M, Bell JD, Miller AD. Folate receptor targeted bimodal liposomes for tumor magnetic resonance imaging. Bioconjugate Chem 2009; 20: 648-655. doi: 10.1021/bc8002259
Crossref Google Scholar
26

Sonvico F, Mornet S, Vasseur S, Dubernet C, Jaillard D, Degrouard J, et al. Folate-conjugated iron oxide nanoparticles for solid tumor targeting as potential specific magnetic hyperthermia mediators:synthesis, physicochemical characterization, and in vitro experiments. Bioconjugate Chemistry 2006; 16: 1181-1188. doi:10.1021/bc05 0050z
Crossref Google Scholar
Nano Biomedicine and Engineering
Volume 3 Issue 3,
September 2011
Pages 157-162
DOI: 10.5101/nbe.v3i3.p157-162
Cite this article:
Tian Z, Shi Y, Yin M, et al. Functionalized Multiwalled Carbon Nanotubesanticancer Drug Carriers: Synthesis, Targeting Ability and Antitumor activity. Nano Biomedicine and Engineering, 2011, 3(3): 157-162. https://doi.org/10.5101/nbe.v3i3.p157-162

372

Views

6

Downloads

26

Crossref

33

Scopus

Altmetrics
Published: 30 September 2011
© 2011 Z. Tian, et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Return