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New Views | Open Access

Microfluidic PCR Chips

Jingdong Chen1, Di Chen1( ), Tao Yuan1, Xiang Chen2
National Key Laboratory of Science and Technology on Micro/Nano Fabrication Technology
Key Laboratory for Thin Film and Microfabrication of the Ministry of Education Research Institute of Mico/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, China
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Abstract

The microfluidic polymerase chain reaction (PCR) chips have undergone extensive development and nowadays have become an important domain of miniaturization technology application. Here, we review the advances of microfluidic PCR chips over the past years, from the first single chamber stationary PCR chip to the new SlipChip PCR. First, the three distinct types of microfluidic PCR chips are discussed, including chamber stationary PCR chips, flow-through PCR chips and convection PCR chips. Then we focus on droplet PCR chips and SlipChip PCR. Although they are at an early stage, they show the great potential for high-throughput PCR and robust chip. Finally, general discussions on integrated chips are given. The low cost, portable, high-throughout integrated PCR chips will certainly be further developed in spite of many challenges.

Keywords

Chamber stationary PCR chipFlow-through PCR chipsConvection PCR chipDroplet PCR chipSlipChip PCRIntegrated PCR chip

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Nano Biomedicine and Engineering
Volume 3 Issue 4,
December 2011
Pages 203-210
DOI: 10.5101/nbe.v3i4.p203-210
Cite this article:
Chen J, Chen D, Yuan T, et al. Microfluidic PCR Chips. Nano Biomedicine and Engineering, 2011, 3(4): 203-210. https://doi.org/10.5101/nbe.v3i4.p203-210

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Published: 31 December 2011
© 2011 J. Chen, et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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