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Article | Open Access

Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization

Muzaffer Mohammed1, Maleeha F Syed1, Mona J Bhatt1, Eugene J Hoffman2, Kadir Aslan1( )
Morgan State University, Department of Chemistry, 1700 East Cold Spring Lane, Baltimore, MD 21251
Morgan State University, Department of Physics, 1700 East Cold Spring Lane, Baltimore, MD 21251
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Abstract

In this paper, we demonstrate the application of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique to rapid and selective crystallization of a small drug compound. i.e. acetaminophen. Subsequent characterization of the crystals by optical microscopy, powder X-ray diffraction (PXRD) and Raman spectroscopy showed quantitatively selective growth of different crystal forms at various experimental conditions. Acetaminophen crystals were grown predominantly as Form Ⅰ (99%) on blank glass slides at room temperature. Form Ⅱ crystals with 39% purity grown on SIFs using microwave energy.

Keywords

CrystallizationSilver NanoparticlesAcetaminophenMetal-Assisted and Microwave-Accelerated Evaporative Crystallization

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Nano Biomedicine and Engineering
Volume 4 Issue 1,
March 2012
Pages 35-40
DOI: 10.5101/nbe.v4i1.p35-40
Cite this article:
Mohammed M, Syed MF, Bhatt MJ, et al. Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization. Nano Biomedicine and Engineering, 2012, 4(1): 35-40. https://doi.org/10.5101/nbe.v4i1.p35-40

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Published: 31 March 2012
© 2012 M. Mohammed, et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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