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Views | Open Access

Biological Applications of Graphene and Graphene Oxide

Congyu Wu, Yan zhang, Xiaochen Wu, Yongqiang Yang, Xuejiao Zhou, Haixia Wu( )
Key Laboratory for Thin Film and Microfabrication of the Ministry of Education, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, P. R. China
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Abstract

Graphene, as a steady two dimensional (2D) carbon material, possesses intriguing physical and chemical properties, which arouses great interests of scientists for its applications in enormous fields. In particular, graphene and graphene oxide have been widely used for drug delivery and DNA detection based on π-π stacking and hydrophobic interactions. Besides, graphene with fluorescent molecules or nanoparticles and graphene quantum dots have also been frequently applied as fluorescent probe. In this article, advances of graphene and graphene oxide on biomedical applications will be highlighted from the perspective of biomolecular interaction, cell imaging, drug delivery, and toxicity.

Keywords

GrapheneGraphene oxideToxicityBiological application

References

1

K.S. Novoselov, A.K. Geim, S.V. Morozov, D. Jiang. Y Zhang, S.V. Dubonos, I.V. Grigorieva, A.A.Firsov, Electric field effect in atomically thin carbon films. Science 2004; 306: 666-9.
Crossref Google Scholar
2

Z.S. Wu, W. Ren, L. Gao, J. Zhao, Z. Chen, B. Liu, D. Tang, B. Yu, C. Jiang, H.M. Cheng, Synthesis of graphene sheets with high electrical conductivity and good thermal stability by hydrogen arc discharge exfoliation. ACS Nano 2009; 3: 411-7.
Crossref Google Scholar
3

A. Reina, X Jia, J. Ho, D. Nezich, H. Son; V. Bulovic, M.S. Dresselhaus, J. Kong, Large area, few-layer graphene films on arbitrary substrates by chemical vapor deposition. Nano Lett. 2009; 9: 30-35.
Crossref Google Scholar
4

P.W. Sutter, J.I. Flege, E.A. Sutter, Epitaxial graphene on ruthenium. Nat. Mater. 2008; 7: 406-11.
Crossref Google Scholar
5

D. Li, M.B. Müller, S. Gilje, R.B. Kaner, G.G. Wallace, Processable aqueous dispersions of graphene nanosheets. Nat. Nanotechnol. 2008; 3: 101-105.
Crossref Google Scholar
6

V.C. Tung, M.J. Allen, Y. Yang, R.B. Kaner, High-throughput solution processing of large-scale graphene. Nat. Nanotechnol. 2009; 4: 25-29.
Crossref Google Scholar
7

J. Zhang, H. Yang, G. Shen, P. Cheng, J. Zhang, S. Guo, Reduction of graphene oxide vial-ascorbic acid. Chem. Comm. 2010; 46: 1112.
Crossref Google Scholar
8

T. Kuila, S. Bose, P. Khanra, A.K. Mishra, N.H. Kim, J.H. Lee, A green approach for the reduction of graphene oxide by wild carrot root. Carbon 2012; 50: 914-921.
Crossref Google Scholar
9

A.K. Geim, Graphene: status and prospects. Science 2009; 324: 1530-1534.
Crossref Google Scholar
10

L. Feng, Z. Liu, Graphene in biomedicine: opportunities and challenges. Nanomedicine (Lond) 2011; 6: 317-324.
Crossref Google Scholar
11

A.K. Geim, K.S. Novoselov, The rise of graphene. Nat. Mater. 2007; 6: 183-191.
Crossref Google Scholar
12

S. Guo, S. Dong, Graphene and its derivative-based sensing materials for analytical devices. J. Mater. Chem. 2011; 21: 18503.
Crossref Google Scholar
13

S. Yang, X. Feng, S. Ivanovici, K. Mullen, Fabrication of graphene-encapsulated oxide nanoparticles: towards high-performance anode materials for lithium storage. Angew. Chem. Int. Ed. Engl. 2010; 49: 8408-8411.
Crossref Google Scholar
14

Z. Liu, J.T. Robinson, X. Sun, H. Dai, PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J Am Chem Soc. 2008; 130: 10876-7.
Crossref Google Scholar
15

X. Sun, Z. Liu, K. Welsher, J.T. Robinson, A. Goodwin, S. Zaric, H. Dai, Nano-graphene oxide for cellular imaging and drug delivery. Nano Res. 2008; 1: 203-212.
Crossref Google Scholar
16

H. Lei, L. Mi, X. Zhou, J. Chen, J. Hu, S. Guo, Y. Zhang, Adsorption of double-stranded DNA to graphene oxide preventing enzymatic digestion. Nanoscale 2011; 3: 3888.
Crossref Google Scholar
17

H. Ren, C. Wang, J. Zhang, X. Zhou, D. Xu, J. Zheng, S. Guo, DNA cleavage system of nanosized graphene oxide sheets and copper ions. ACS Nano 2010; 4: 7169-74.
Crossref Google Scholar
18

M. Wu, R. Kempaiah, J.J. Huang, V. Maheshwari, J. Liu, Adsorption and Desorption of DNA on Graphene Oxide Studied by Fluorescently Labeled Oligonucleotides. Langmuir 2011; 27: 2731-2738.
Crossref Google Scholar
19

H. Bao, Y. Pan, Y. Ping, N.G. Sahoo, T. Wu, L. Li, J. Li, L.H. Gan, Chitosan-functionalized graphene oxide as a nanocarrier for drug and gene delivery. Small 2011; 7: 1569-1578.
Crossref Google Scholar
20

Y. Zhang, J. Zhang, X. Huang, X. Zhou, H. Wu, S. Guo, Assembly of graphene oxide-rnzyme vonjugates through hydrophobic interaction. Small 2012; 8: 154-159.
Crossref Google Scholar
21

C.H. Lu, H.H. Yang, C.L. Zhu, X. Chen, G.N. Chen, A Graphene platform for sensing biomolecules. Angew. Chem. Int. Ed. 2009; 48: 4785-4787.
Crossref Google Scholar
22

L. Zhang, Z. Lu, Q. Zhao, J. Huang, H. Shen, Z. Zhang, Enhanced chemotherapy efficacy by sequential delivery of siRNA and anticancer drugs using PEI-grafted graphene oxide. Small 2011; 7: 460-464.
Crossref Google Scholar
23

L. Feng, S. Zhang, Z. Liu, Graphene based gene transfection. Nanoscale 2011; 3: 1252.
Crossref Google Scholar
24

M.L. Chen, J.W. Liu, B. Hu, J.H. Wang, Conjugation of quantum dots with graphene for fluorescence imaging of live cells. Analyst 2011; 136: 4277-83.
Crossref Google Scholar
25

C. Peng, W. Hu, Y. Zhou, C. Fan, Q. Huang, Intracellular imaging with a graphene-based fluorescent probe. Small 2010; 6: 1686-1692.
Crossref Google Scholar
26

S. Zhu, J. Zhang, C. Qiao, S. Tang, Y. Li, W. Yuan, B. Li, L. Tian, F. Liu, R. Hu, H. Gao, H. Wei, H. Zhang, H. Sun, B. Yang, Strongly green-photoluminescent graphene quantum dots for bioimaging applications. Chem. Comm. 2011; 47: 6858.
Crossref Google Scholar
27

X. Sun, D. Luo, J. Liu, D.G. Evans, Monodisperse chemically modified graphene obtained by density gradient ultracentrifugal rate separation. ACS Nano 2010; 4: 3381-3389.
Crossref Google Scholar
28

R. Liu, D. Wu, X. Feng, K. Mullen, Bottom-up fabrication of photoluminescent graphene quantum dots with uniform morphology. J. Am. Chem. Soc. 2011; 133: 15221-15223.
Crossref Google Scholar
29

L.A. Ponomarenko, F. Schedin, M.I. Katsnelson, R. Yang, E.W. Hill, K.S. Novoselov, A.K. Geim, Chaotic Dirac billiard in graphene quantum dots. Science 2008; 320: 356-358.
Crossref Google Scholar
30

J. Peng, W. Gao, B.K. Gupta, Z. Liu, R. Romero-Aburto, L. Ge, L. Song, L.B. Alemany, X. Zhan, G. Gao, S.A. Vithayathil, B.A. Kaipparettu, A.A. Marti, T. Hayashi, J.J. Zhu, P.M. Ajayan, Graphene quantum dots derived from carbon fibers. Nano Lett. 2012: 120106121847009.
Crossref Google Scholar
31

J. Lu, J.X. Yang, J. Wang, A. Lim, S. Wang, K.P. Loh, One-pot synthesis of fluorescent carbon nanoribbons, nanoparticles, and graphene by the exfoliation of graphite in ionic liquids. ACS Nano 2009; 3: 2367-2375.
Crossref Google Scholar
32

Y. Xu, A. Malkovskiy, Y. Pang, A graphene binding-promoted fluore-scence enhancement for bovine serum albumin recognition. Chem. Comm. 2011; 47: 6662-6664.
Crossref Google Scholar
33

K. Yang, S. Zhang, G. Zhang, X. Sun, S.T. Lee, Z. Liu, Graphene in mice: ultrahigh in vivo tumor uptake and efficient photothermal therapy. Nano Lett. 2010; 10: 3318-3323.
Crossref Google Scholar
34

B. Tian, C. Wang, S. Zhang, L. Feng, Z. Liu, Photothermally enhanced photodynamic therapy delivered by nano-graphene oxide. ACS Nano 2011; 5: 7000-7009.
Crossref Google Scholar
35

Y. Chang, S.T. Yang, J.H. Liu, E. Dong, Y. Wang, A. Cao, Y. Liu. H. Wang, In vitro toxicity evaluation of graphene oxide on A549 cells. Toxicol. Lett. 2011; 200: 201-210.
Crossref Google Scholar
36

Y. Zhang, S.F. Ali, E. Dervishi, Y. Xu, Z. Li, D. Casciano, A.S. Biris, Cytotoxicity effects of graphene and single-wall carbon nanotubes in neural phaeochromocytoma-derived PC12 cells. ACS Nano 2010; 4: 3181-3186.
Crossref Google Scholar
37

K.H. Liao, Y.S. Lin, C.W. Macosko, C.L. Haynes, Cytotoxicity of graphene oxide and graphene in human erythrocytes and skin fibroblasts. ACS appl. mater. inter. 2011; 3: 2607-2615.
Crossref Google Scholar
Nano Biomedicine and Engineering
Volume 4 Issue 4,
December 2012
Pages 157-162
DOI: 10.5101/nbe.v4i4.p157-162
Cite this article:
Wu C, zhang Y, Wu X, et al. Biological Applications of Graphene and Graphene Oxide. Nano Biomedicine and Engineering, 2012, 4(4): 157-162. https://doi.org/10.5101/nbe.v4i4.p157-162

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Published: 31 December 2012
© 2012 C.Y. Wu et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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