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Article | Open Access

Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections

Elvira De Giglio1( ), Adriana Trapani2, Damiana Cafagna1, Concetta Ferretti3, Roberta Iatta4, Stefania Cometa5, Edmondo Ceci6, Antonella Romanelli1, Monica Mattioli-Belmonte3
Dept. of Chemistry, University of BariAldo Moro,Bari,Italy
Dept. of Pharmacy, University of BariAldo Moro,Bari,Italy
Dept. of Clinical and Molecular Sciences, UniversitàPolitecnicadelle Marche, Ancona, Italy
Dept. of Biomedical Sciences and Human Oncology, University of BariAldo Moro, Bari, Italy
BIOLab, Chemistry & Industrial Chemistry Department, University of Pisa, Pisa, Italy
Department of Public Health, University of Bari Aldo Moro, Bari, Italy
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Abstract

Orthopaedic infections represent one of the major causes of implant failure. Systemic treatment is limited due to dosing, side-effects, patient compliance, treatment length and resistant bacteria. The choice of antibiotic incorporation method has been the subject of many investigations and, nowadays, various vehicles for local drug delivery have been studied. In this work, a novel ciprofloxacin loaded chitosan nanoparticles coating system onto titanium surface has been developed and characterized. The antibiotic release capability of this system and its ability to inhibit the in vitro growth of two of the most common pathogens causing orthopaedic implant-related infections, Staphylococcus aureus and Pseudomonas aeruginosa, have been evaluated. Preliminary biocompatibility data arising from MG63 osteoblast-like cells seeding on the ciprofloxacin-loaded systems have also been discussed. The investigated system represents a promising candidate in view of the development of new antibiotic carriers in situ for preventing titanium implant-associated infections.

Keywords

InfectionTitaniumChitosan NanoparticlesCiprofloxacinDrug ReleaseOsteoblast

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Nano Biomedicine and Engineering
Volume 4 Issue 4,
December 2012
Pages 163-169
DOI: 10.5101/nbe.v4i4.p163-169
Cite this article:
De Giglio E, Trapani A, Cafagna D, et al. Ciprofloxacin-loaded Chitosan Nanoparticles as Titanium Coatings: A Valuable Strategy to Prevent Implant-associated Infections. Nano Biomedicine and Engineering, 2012, 4(4): 163-169. https://doi.org/10.5101/nbe.v4i4.p163-169

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Published: 31 December 2012
© 2012 E.De Giglio et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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