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Article | Open Access

Ceria nanoparticles boost activity of aged murine oocytes

NYa Spivak1, EA Shepel2, NM Zholobak1, AB Shcherbakov1( ), GV Antonovitch1, RI Yanchiy2, VK Ivanov3,4, YuD Tretyakov3,4
Zabolotny Institute of Microbiology and Virology, NAS of Ukraine, Zabolotnogo str. 154, Kiev, D 03680, Ukraine
Bogomoletz Institute of Physiology, NAS of Ukraine, Bogomoletz str. 4, Kiev, 01024, Ukraine
Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Leninskii pr. 31, Moscow, 119991, Russia
Department of Materials Science of Moscow State University, Lenin Hills, Moscow, 119991, Russia
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Abstract

Oocyte meiotic maturation and viability of follicular granulosa cells in young and old experimental Balb/C and CBA mice in the presence of ceria nanoparticles were studied. Treatment of old Balb/c mice with ceria nanoparticles for three days once a day (at a dose of 45 mg/kg) leads to a positive effect on reproductive system. The number of oocytes in follicles increases and this effect is accompanied by an increase in the number of oocytes at metaphase Ⅰ and metaphase Ⅱ. The number of living granulosa cells increases, while percentage of the necrotic and apoptotic ones decreases relative to control group. Data obtained on CBA mice provided additional evidence for positive effect of ceria nanoparticles. Depending on the initial state of the reproductive system and dose of ceria nanoparticles the effectiveness of the treatment will vary. In case of old mice ceria nanoparticles protect ovarian cells against oxidative damage, working as anti-aging agent. The litter size in old mice treated with the CNs increases too.

Keywords

CeriaNanoparticleAntioxidantsOocyte meiotic maturationGranulosa cell viability

References

1

Jakupec M.A., Unfried P., Keppler B.K., Pharmacological properties of cerium compounds. Rev. Physiol. Biochem. Pharmacol. 2005;153:101-111.
Crossref Google Scholar
2

Karakoti A.S., Monteiro-Riviere N.A., Aggarwal R., Davis J.P., Narayan R.J., Self W.T., Nanoceria as Antioxidant: Synthesis and Biomedical Applications. JOM 2008;60(3):33.
Crossref Google Scholar
3

Ivanov V.K., Shcherbakov A.B., Usatenko A.V., Structure-sensitive properties and biomedical applications of nanodispersed cerium dioxide. Russ. Chem. Rev. 2009;78(9):855-71.
Crossref Google Scholar
4

Celardo I., Pedersen J.Z., Travers E., Ghibelli L., Pharmacological potential of cerium oxide nanoparticles. Nanoscale 3(4):1411-21.
Crossref Google Scholar
5

Shcherbakov A.B., Ivanov V.K., Zholobak N.M., Ivanova O.S., Krysanov EIu, Baranchikov A.E., Nanocrystaline ceria based materials-perspectives for biomedical application. Biofizika. 2011;56(6):995-1015.
Crossref Google Scholar
6

Zholobak N.M., Ivanov V.K., Shcherbakov A.B., Shaporev A., Polezhaeva O.S., Baranchikov A.Y., UV-shielding property, photocatalytic activity and photocytotoxicity of ceria colloid solutions. J. Photochem. Photobiol. B. 2011;102:32-38.
Crossref Google Scholar
7

Zholobak N., Shcherbakov A., Ivanov V., Olevinskaya Z., Spivak N., Antiviral effectivity of ceria colloid solutions. Antiviral Res. 2011; 90, 2:67.
Crossref Google Scholar
8

Heckert E.G., Karakoti A.S., Seal S., Self W.T., The role of cerium redox state in the SOD mimetic activity of nanoceria. Biomaterials. 2008;29:2705-2709.
Crossref Google Scholar
9

Schubert D., Dargusch R., Raitano J., Chan S.W., Cerium and yttrium oxide nanoparticles are neuroprotective. Biochem. Biophys. Res. Commun. 2006; 342:86-91.
Crossref Google Scholar
10
Hirst S.M., Karakoti A., Singh S., Self W., Tyler R., Seal S., Biodistribution and In Vivo Antioxidant Effects of Cerium Oxide Nanoparticles in Mice. Environmental Toxicology. Published online in Wiley Online Library.
11

Kregel K.C., Zhang H.J., An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations.Am J Physiol. Regul. Integr. Comp. Physiol. 2007;292(1):18-36.
Crossref Google Scholar
12

Ivanov V.K., Polezhaeva O.S., Shaporev A.S., Baranchikov A.E., Shcherbakov A.B., Usatenko A.V., Synthesis and thermal stability of nanocrystalline ceria sols stabilized by citric and polyacrylic acid. Russ. J. Inorg. Chem. 2010;55(3):328-332.
Crossref Google Scholar
13

Shimizu S., Eguchi Y., Kamiike W., Akao Y., Kosaka H., Hasegawa J., Involvement of ICE family proteases in apoptosis induced by reoxygenation of hypoxic hepatocytes. Am. J. Physiol. 1996;271:949-958.
Crossref Google Scholar
14

Ciancio G., Pollack A., Taupier M.A., Block N.L., Irvin G.L, Measurement of cell-cycle phasespecific cell death using Hoechst 33342 and propidium iodide: preservation by ethanol fixation. J. Histochem. Cytochem. 1988;36(9):1147-1152.
Crossref Google Scholar
15

Agarwal A., Saleh R.A., Bedaiwy M.A., Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil. Steril. 2003;79(4):829-843.
Crossref Google Scholar
16

Agarwal A., Gupta S., Sharma R.K., Role of oxidative stress in female reproduction. Reprod. Biol. Endocrinol. 2005;3:28
Crossref Google Scholar
17

Behrman H.R., Kodaman P.H., Preston S.L., Gao S., Oxidative stress and the ovary. J. Soc. Gynecol. Investig. 2001;8:40-42.
Crossref Google Scholar
18

Sabatini L., Wilson C., Lower A., Al-Shawaf T., Grudzinskas J.G., Superoxide dismutase activity in human follicular fluid after controlled ovarian hyperstimulation in women undergoing in vitro fertilization. Fertil. Steril. 1999;72:1027-1034.
Crossref Google Scholar
19

Ishikawa M., Oxygen radicals-superoxide dismutase system and reproduction medicine. Nippon Sanka Fujinka Gakkai Zasshi. 1993;45:842-848.
Google Scholar
20

Martín-Romero F.J., Miguel-Lasobras E.M., Domínguez-Arroyo J.A., González-Carrera E., Alvarez I.S., Contribution of culture media to oxidative stress and its effect on human oocytes. Reprod. Biomed. Online. 2008;17(5):652-61.
Crossref Google Scholar
21

Ménézo Y., Guérin P., Gamete and embryo protection against oxidative stress during medically assisted reproduction. Bull. Acad. Natl. Med. 2005;189(4):715-26.
Google Scholar
22

Lu C., Koppenol W.H., Inhibition of the Fenton reaction by nitrogen monoxide. J. Biol. Inorg. Chem. 2005; 10:732-738.
Crossref Google Scholar
23

Voznesenska T.Yu, Blashkiv T.V., Shepel O.A., Yanchiy R.I., Experimental aspects of disturbances of reproductive function. Kyiv: Milanik. 2010, 184
Google Scholar
24

Shkolnik K., Tadmor A., Ben-Dor S., Nevo N., Galiani D., Dekel N., Reactive oxygen species are indispensable in ovulation. Proc. Natl. Acad. Sci. USA. 2011;108(4):1462-1467.
Crossref Google Scholar
25

Eppig J.J., Role of serum in FSH stimulated cumulus expansion by mouse oocyte-cumulus cell complexes in vitro. Biol. Reprod. 1980;22(3):629-633.
Crossref Google Scholar
26

Ma S., Lin H., Miao Y., Liu X., Wang B., Dai J., The effect of three-dimensional demineralized bone matrix on in vitro cumulus-free oocyte maturation. Biomat. 2007;28:3198-3207.
Crossref Google Scholar
27

Voznesenskaia TIu, Blashkiv T.V., Portnichenko A.G., Effect of cumulus and granulosa cells on meiosis resumption in murine oocytes in vitro. Tsitologiia. 2001;43(3):250-253.
Google Scholar
28

Dell'Aquila M.E., Caillaud M., Maritato F., Martoriati A., Gérard N., Aiudi G., Cumulus expansion, nuclear maturation and connexin, cyclooxygenase-2 and FSH receptor mRNA expression in equine cumulus-oocyte complexes cultured in vitro in the presence of FSH and precursors for hyaluronic acid synthesis. Reprod. Biol. Endocrinol. 2004;22:44.
Crossref Google Scholar
29

Marchal R., Caillaud M., Martoriati A., Gerard N., Mermillod P., Goudet G., Effect of growth hormone (GH) on in vitro nuclear and cytoplasmic oocyte maturation, cumulus expansion, hyaluronan synthases, and connexins and expression, and GH receptor messenger RNA expression in equine and porcine species. Biol. Reprod. 2003;69:1013-1022.
Crossref Google Scholar
30

Ka H.H., Sawai K., Wang W.H., Im K.S., Niwa K., Amino acids in maturation medium and presence of cumulus cells at fertilization promote male pronuclear formation in porcine oocytes matured and penetrated in vitro. Biol. Reprod. 1997;57:1478-1483.
Crossref Google Scholar
31

Yamauchi N., Nagai T., Male pronuclear formation in denuded porcine oocytes after in vitro maturation in the presence of cysteamine. Biol. Reprod. 1999;61:823-833.
Crossref Google Scholar
32

Marchal R., Tomanek M., Terqui M., Mermillod P., Effects of cell cycle dependent kinases inhibitor on nuclear and cytoplasmic maturation of porcine oocytes. Mol. Reprod. Dev. 2001;60:65-73.
Crossref Google Scholar
33

Tatemoto H., Muto N., Sunagawa I., Shinjo A., Nakada T., Protection of porcine oocytes against cell damage caused by oxidative stress during in vitro maturation: role of superoxide dismutase activity in porcine follicular fluid. Biol. Reprod. 2004;71(4):1150-1157.
Crossref Google Scholar
34

Niwa K., Effectiveness of in vitro maturation and in vitro fertilization techniques in pig.J. Reprod. Fertil. 1993;48:49-59.
Google Scholar
35

Ruder E.H., Hartman T.J., Blumberg J., Goldman M.B., Oxidative stress and antioxidants: exposure and impact on female fertility. Hum. Reprod. Update. 2008;14:345-37.
Crossref Google Scholar
36

Sekhon L.H., Gupta S., Kim Y., Agarwal A., Female Infertility and Antioxidants. Curr. Womens Health Rev. 2010;6: 84-95.
Crossref Google Scholar
37

Tantone C., Oocyte senescence: A firm link to age-related female. Gynecol. Endocrinol. 2008;24(2):59-63.
Crossref Google Scholar
38

Su Y.Q., Sugiura K., Woo Y., Wigglesworth K., Kamdar S., Affourtit J., Selective degradation of transcripts during meiotic maturation of mouse oocytes. Dev. Biol. 2007;302(1): 104-117.
Crossref Google Scholar
Nano Biomedicine and Engineering
Volume 4 Issue 4,
December 2012
Pages 188-194
DOI: 10.5101/nbe.v4i4.p188-194
Cite this article:
Spivak N, Shepel E, Zholobak N, et al. Ceria nanoparticles boost activity of aged murine oocytes. Nano Biomedicine and Engineering, 2012, 4(4): 188-194. https://doi.org/10.5101/nbe.v4i4.p188-194

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Published: 31 December 2012
© 2012 NYa Spivak et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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