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Review | Open Access

Nanoparticle-based Optical Detection of MicroRNA

Jingpu Zhang, Daxiang Cui( )
Department of Bio-Nano Science and Engineering, Key Laboratory for Thin Film and Micro fabrication Technology of Ministry of Education, National Key Laboratory of Micro /Nano Fabrication Technology, Research Institute of Micro/Nano Science and Technology, Shanghai Jiao Tong University, Shanghai, 200240, P.R. China
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Abstract

MiRNAs are valuable biomarkers for diagnosis and prognosis of cancers, so it is imperative to develop rapid, sensitive, high throughput miRNA detection methods. In this review article, the current nanoparticle-based miRNA detection by optical technology was summarized from the following aspects about fluorescence, scattering and colorimetry. And the emphasis is laid on employing quantum dots (QDs) and silver nanoclusters (AgNCs)- based fluorescence and silver nanorod-based surface enhanced Raman scattering (SERS) to detect miRNAs. Nanoparticle-based optical detection is prospective for multiplexed miRNA detection or in vivo imaging.

Keywords

Quantum dotsColorimetric detectionSurface enhanced Raman scatteringSilver nanoclustersMicroRNA detection

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Nano Biomedicine and Engineering
Volume 5 Issue 1,
March 2013
Pages 1-10
DOI: 10.5101/nbe.v5i1.p1-10
Cite this article:
Zhang J, Cui D. Nanoparticle-based Optical Detection of MicroRNA. Nano Biomedicine and Engineering, 2013, 5(1): 1-10. https://doi.org/10.5101/nbe.v5i1.p1-10

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Published: 30 March 2013
© 2013 J.P. Zhang and D.X. Cui.

This is an openaccess article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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