AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Nano Biomedicine and Engineering Article
PDF (814.6 KB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Article | Open Access

Application of Plackett-Burman Factorial Design in The Development of Curcumin Loaded Eudragit E 100 Nanoparticles

Moorthi Chidambaram( ), Kathiresan Krishnasamy
Department of Pharmacy, Annamalai University, Annamalai Nagar - 608 002, Chidambaram, Tamil Nadu, India
Show Author Information

Abstract

The present study was aimed to fabricate Curcumin loaded Eudragit E 100 polymeric nanoparticles and to study the effect of various manufacturing parameters on the average particle size, span, uniformity and surface area of the prepared polymeric nanoparticles by utilizing Plackett-Burman experimental designs. Curcumin loaded Eudragit E 100 nanoparticles were prepared by nanoprecipitation method and characterized using particle size analyser. Plackett-Burman design was implemented to study the influence of eight independent variables on three dependent variables. Twelve experimental trials involving 8 independent variables at higher and lower levels were generated by Design-Expert. Out of 12 trials, 4th and 9th trails were within the acceptable limits. Least average particle size can be obtained by increasing the concentration of poloxamer 188, increasing the volume of aqueous phase, increasing the sonication duration and decreasing the ethanol concentration. Similarly, span less than 1 can be obtained by increasing the concentration of poloxamer 188, increasing the sonication duration and decreasing the ethanol concentration. However, uniformity can be increased decreasing the ethanol concentration. Higher surface area can be obtained by increasing the concentration of Eudragit E 100, poloxamer 188 and increasing the volume of the aqueous phase.

Keywords

CurcuminNanoprecipitationPolymeric NanoparticlesEudragit E 100Plackett-Burman Design

References

[1]

Moorthi C., Kiran K., Manavalan R., Kathiresan, K., Preparation and characterization of curcumin-piperine dual drug loaded nanoparticles. Asian Pac. J. Trop. Biomed. 2012; 2: 841-848.
Crossref Google Scholar
[2]

Moorthi C., Kathiresan K., Curcumin-Piperine/Curcumin-Silibinin/Curcumin-Silibinin dual drug loaded nanoparticulate combination therapy: A novel approach to target and treat multidrug resistant cancers. J. Med. Hypotheses Ideas. 2012; doi:http://dx.doi.org/10.1016/j.jmhi.2012.10.005.
Crossref Google Scholar
[3]

Aggarwal B.B., Sundaram C., Malani N., Ichikawa H., Curcumin: The Indian solid gold. Adv. Exp. Med. Biol. 2007; 595: 1-75.
Crossref Google Scholar
[4]

Zhou H., Beevers C.S., Huang S., Targets of curcumin. Curr. Drug Targets. 2011; 12: 332-347
Crossref Google Scholar
[5]

Wilken R., Veena M.S., Wang M.B., Srivatsan E.S., Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma. Mol. Cancer. 2011; 10:12.
Crossref Google Scholar
[6]

Mohanachandran P.S., Sindhumol P. G., Kiran T. S., Enhancement of solubility and dissolution rate: an overview. International Journal of Comprehensive Pharmacy. 2010; 1: 1-10.
Google Scholar
[7]

Moorthi C., Manavalan R, Kathiresan K., Nanotherapeutics to overcome conventional cancer chemotherapy limitations. J. Pharm. Pharm. Sci. 2011; 14: 67-77.
Crossref Google Scholar
[8]

Ajazuddin R.T., Giri T.K., Tripathi D.K., Jain V., Alexander A., An exhastative review on solubility enhancement for hydrophobics compound by possible application of novels techniques. Trends Applied Sci. Res. 2012; 7: 596-619.
Crossref Google Scholar
[9]

Chaudhary A., Nagaich U., Gulati N., Sharma V.K., Khosa R.L., Partapur M.U., Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: A recent review. Journal of Advanced Pharmacy Education & Research.2012; 2: 32-67.
Google Scholar
[10]

Kulthe S.S., Inamdar N.N., Choudhari Y.M., Shirolikar S.M., Borde L.C., Mourya V.K., Mixed micelle formation with hydrophobic and hydrophilic Pluronic block copolymers: Implications for controlled and targeted drug delivery. Colloid Surface B. 2011; 88: 691-696.
Crossref Google Scholar
[11]

Mu C.F., Balakrishnan P., Cui F.D., Yin Y.M., Lee Y.B., Choi H.G., Yong C.S., Chung S.J., Shim C.K., Kim D.D., The effects of mixed MPEG-PLA/Pluronic copolymer micelles on the bioavailability and multidrug resistance of docetaxel. Biomaterials. 2010; 31: 2371-2379.
Crossref Google Scholar
[12]

Chang Y.C., Chu I., Methoxy poly(ethylene glycol)-bpoly(valerolactone) diblock polymeric micelles for enhanced encapsulation and protection of camptothecin. Eur. Polym. J. 2008; 44: 3922-3930.
Crossref Google Scholar
[13]

Wang J., Mongayt D., Torchilin V.P., Polymeric micelles for delivery of poorly soluble drugs: preparation and anticancer activity in vitro of paclitaxel incorporated into mixed micelles based on poly (ethylene glycol)-lipid conjugate and positively charged lipids. J. Drug Target. 2005; 13: 73-80.
Crossref Google Scholar
[14]

Duan R.L., Sun X., Liu J., Gong T., Zhang Z.R., Mixed micelles loaded with silybin-polyene phosphatidylcholine complex improve drug solubility. Acta. Pharmacol. Sin. 2011; 32: 108-115.
Crossref Google Scholar
[15]

Rachmawati H., Shaal L.A., Müller R.H., Keck C.M., Development of curcumin nanocrystal: Physical aspects. J. Pharm. Sci. 2013; 102: 204-214.
Crossref Google Scholar
[16]

Dhaval J.P., Jayvadan K.P., Mucoadhesive effect of polyethylene oxide on famotidine nanosuspension prepared by solvent evaporation method. Int. J. Pharm. Pharm. Sci. 2010; 2: 122-127.
Google Scholar
[17]

Du Toit L.C., Pillay V., Choonara Y.E., Iyuke S.E., Formulation and evaluation of a salted-out isoniazid-loaded nanosystem. AAPS PharmSciTech. 2008; 9: 174-181.
Crossref Google Scholar
[18]

Khayata N., Abdelwahed W., Chehna M.F., Charcosset C., Fessi H., Preparation of vitamin E loaded nanocapsules by the nanoprecipitation method: From laboratory scale to large scale using a membrane contactor. Int. J. Pharm. 2012; 423:419-427.
Crossref Google Scholar
[19]

Choi S.W., Kim J.H., Design of surface-modified poly (D, L-lactide-co-glycolide) nanoparticles for targeted drug delivery to bone. J. Control. Release. 2007; 122: 24-30.
Crossref Google Scholar
[20]

Schafroth N., Arpagaus C., Jadhav U.Y., Makne S., Douroumis D., Nano and microparticle engineering of water insoluble drugs using a novel spray-drying process. Colloids Surface B. 2012; 90: 8-15.
Crossref Google Scholar
[21]

Gülseren İ., Fang Y., Corredig M., Zinc incorporation capacity of whey protein nanoparticles prepared with desolvation with ethanol. Food Chem. 2012; 135: 770-774.
Crossref Google Scholar
[22]

Mudgili M., Gupta N., Nagpal M., Pawar P., Nanotechnology: A new approach for ocular drug delivery system. Int. J. Pharm. Pharm. Sci. 2012; 4: 105-112.
Google Scholar
[23]

Sailaja A., Amareshwar P., Chakravarty P., Different techniques used for the preparation of nanoparticles using natural polymers and their application. Int. J. Pharm. Pharm. Sci. 2011; 3: 45-50.
Google Scholar
[24]

De Giglio E., Trapani A., Cafagna D., Ferretti C., Iatta R., Cometa, S, Ceci E., Romanelli A., Mattioli-Belmonte M., Ciprofloxacinloaded Chitosan Nanoparticles as titanium coatings: a valuable strategy to prevent implant-associated infections. Nano Biomed. Eng. 2012; 4: 163-169.
Crossref Google Scholar
[25]

Rahman Z., Zidan A.S., Habib M.J., Khan M.A., Understanding the quality of protein loaded PLGA nanoparticles variability by Plackett–Burman design. Int. J. Pharm., 2010; 389: 186-194.
Crossref Google Scholar
[26]

Anastácio A., Carvalho I.S., Phenolics extraction from sweet potato peels: Key factors screening through a Placket–Burman design. Ind. Crop. Prod. 2013; 43: 99-105.
Crossref Google Scholar
[27]

Awotwe-Otoo D., Zidan A.S., Rahman Z., Habib M.J., Evaluation of anticancer drug-loaded nanoparticle characteristics by nondestructive methodologies. AAPS PharmSciTech. 2012; 13: 611-622.
Crossref Google Scholar
[28]

Singh N., Rai V., Improved antimicrobial compound production by a new isolate Streptomyces hygroscopicus MTCC 4003 using Plackett-Burman design and response Surface methodology. Bioinformation. 2012; 8: 1021-1025.
Crossref Google Scholar
[29]

Ahmad M., Panda B.P., Screening of nutrient parameters for red pigment production by Monascus purpureus MTCC 369 under solid state fermentation by using Plackett-Burman experimental design. Chiang. Mai. J. Sci. 2009; 36: 104-109.
Google Scholar
[30]

Xie H., Smith J.W., Fabrication of PLGA nanoparticles with a fluidic nanoprecipitation system. J Nanobiotechnology. 2010; 8(18): 1-7
Crossref Google Scholar
[31]

Lakshmi P., Ashwini K.G., Nanosuspension technology: A review. Int. J. Pharm. Sci. 2010; 2:35-40.
Google Scholar
Nano Biomedicine and Engineering
Volume 5 Issue 1,
March 2013
Pages 28-33
DOI: 10.5101/nbe.v5i1.p28-33
Cite this article:
Chidambaram M, Krishnasamy K. Application of Plackett-Burman Factorial Design in The Development of Curcumin Loaded Eudragit E 100 Nanoparticles. Nano Biomedicine and Engineering, 2013, 5(1): 28-33. https://doi.org/10.5101/nbe.v5i1.p28-33

296

Views

4

Downloads

3

Crossref

0

Scopus

Altmetrics
Published: 30 March 2013
© 2013 M. Chidambaram and K. Krishnasamy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Return