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Article | Open Access

A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation Technique

Moorthi Chidambaram( ), Kathiresan Krishnasamy
Department of Pharmacy, Annamalai University, Annamalai Nagar - 608 002, Chidambaram, Tamil Nadu, India
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Abstract

The primary aim of the study was to prepare narrow sized polymeric nanoparticles by implementing few modifications to the conventional nanoprecipitation technique and to evaluate the effect of various process parameters on prepared polymeric nanoparticles. Eudragit E 100 nanoparticles were prepared by modified nanoprecipitation technique and step-by-step optimization was carried out to evaluate the effect of various process parameters such as organic solvent, polymer concentration, percentage of organic solvent, mode of addition of organic solvent in to aqueous phase, volume of aqueous phase, poloxamer 188 concentration, β-cyclodextrin concentration, temperature generated during sonication process, sonication duration, and drug concentration on the particle size, surface area, distribution width and uniformity of the prepared nanoparticles. The optimized process parameters were implemented to fabricate dual drug loaded Eudragit E 100 nanoparticles which were spherical in shape with mean particle size in the range of 118 to 140 nm, polydispersity index in the range of 0.187 to 0.254 and zeta potential in the range of 16.6 to 28.8 mV. Thus developed modified nanoprecipitation method can be used to fabricate narrow sized polymeric nanoparticles.

Keywords

Dual drug loaded polymeric nanoparticlesEudragit E 100Modified nanoprecipitation methodStep-by-step optimization

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Nano Biomedicine and Engineering
Volume 5 Issue 3,
September 2013
Pages 107-115
DOI: 10.5101/nbe.v5i3.p107-115
Cite this article:
Chidambaram M, Krishnasamy K. A Step-by-Step Optimization Process to Fabricate Narrow Sized Dual Drug Loaded Polymeric Nanoparticles Using Modified Nanoprecipitation Technique. Nano Biomedicine and Engineering, 2013, 5(3): 107-115. https://doi.org/10.5101/nbe.v5i3.p107-115

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Published: 30 September 2013
© 2013 M. Chidambaram and K. Krishnasamy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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