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Research Article | Open Access

Calcium Phosphate/Etidronate Disodium Biocement: Etidronate, Retarder or Accelerator

Nasim Nosoudi1,2, Amin Hasanzadeh3, Drew Holman2, Sayed Mahmood Rabiee4, Saeed Hesaraki5, Fatollah Moztarzadeh1( ), Michael Gelinsky6
Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
Department of Bioengineering, Clemson University, Clemson, South Carolina, USA
Department of Polymer Engineering, Amirkabir University of Technology, Tehran, Iran
Department of Mechanical Engineering, Babol University of Technology, Babol, Iran
Nanotechnology and Advanced Materials Department, Materials and Energy Research Center, Karaj, Iran
Centre for Translational Bone, Joint and Soft Tissue Research, University Hospital Carl Gustav Carus and Medical Faculty of Technische Universität Dresden, Dresden, Germany
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Abstract

Bisphosphonate release from calcium phosphate cement has been investigated. We hypothesized that local delivery of bisphosphonate from the calcium phosphate cement improves the mechanical properties. Different samples with different concentration of Etidronate disodium have been made and analyzed. We observed a dual behavior from Etidronate in retarding and accelerating the setting of calcium phosphate cement in low and high concentration respectively. After soaking samples in simulated body fluid, an optimum concentration of Etidronate disodium was added to the calcium phosphate paste in order to achieve the best mechanical properties. Scanning electron microscopy (SEM) showed the formation of hydroxyapatite crystals. X-ray diffraction (XRD) analysis was used to determine hydroxyapatite peaks on the surface of the bio-cement, which confirms the hydroxyapatite formation.

Keywords

HydroxyapatiteBisphosphonatesCalcium phosphate bone cementEtidronate disodium

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Nano Biomedicine and Engineering
Volume 6 Issue 1,
March 2014
Pages 40-45
DOI: 10.5101/nbe.v6i1.p40-45
Cite this article:
Nosoudi N, Hasanzadeh A, Holman D, et al. Calcium Phosphate/Etidronate Disodium Biocement: Etidronate, Retarder or Accelerator. Nano Biomedicine and Engineering, 2014, 6(1): 40-45. https://doi.org/10.5101/nbe.v6i1.p40-45

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Received: 19 December 2013
Accepted: 18 February 2014
Published: 15 March 2014
© 2014 Nasim Nosoudi, Amin Hasanzadeh, Drew Holman, Sayed Mahmood Rabiee, Saeed Hesaraki, Fatollah Moztarzadeh and Michael Gelinsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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