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Review | Open Access

Emerging Role of Tumor-associated Macrophages as Therapeutic Targets in Glioblastoma Multiforme

Xian-Bin Lin1, Guo-Han Hu1( ), Hua-Lin Fu2, Wei-Lin Jin2,3( )
Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Bio-X Institutes, Ministry of Education; Institute of Nano Biomedicine and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
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Abstract

The most common types of primary brain tumors in adults are gliomas. Glioblastoma multiforme (GBM) is the most highly aggressive type of glioma. GBM contains various numbers of cells with characteristics of activated or dysmorphic macrophages/microglia. Among them, some cell types provide significant support for tumor growth, while others are able to inhibit tumor progression. These cells are generally considered part of the tumor stroma and are often described as TAMs (tumour-associated macrophages). The presence of TAMs has been linked to increased tumor grade and poor clinical outcome in GBM, suggesting that depletion or inhibition of these cells may suppress tumor growth. A better understanding of tumor microenvironment in the brain would therefore be expected to contribute to the development of improved therapies for brain tumors that are urgently required due to a poor availability of treatments for these malignancies. This review summarizes some of the known interactions between brain tumors and different stromal cells, and also discusses potential therapeutic approaches within this context.

Keywords

microenvironmentNanoprodrugimmunosuppressiveGBMTAMs

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Nano Biomedicine and Engineering
Volume 6 Issue 1,
March 2014
Pages 7-18
DOI: 10.5101/nbe.v6i1.p7-18
Cite this article:
Lin X-B, Hu G-H, Fu H-L, et al. Emerging Role of Tumor-associated Macrophages as Therapeutic Targets in Glioblastoma Multiforme. Nano Biomedicine and Engineering, 2014, 6(1): 7-18. https://doi.org/10.5101/nbe.v6i1.p7-18

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Received: 03 March 2014
Accepted: 18 March 2014
Published: 20 March 2014
© 2014 Xian-Bin Lin, Guo-Han Hu, Hua-Lin Fu and Wei-Lin Jin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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