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Research Article | Open Access

Investigation of Phloroglucinol Succinic Acid Dendrimer as Antimicrobial Agent Against Staphylococcus Aureus, Escherichia Coli and Candida Albicans

Murugesan Suresh Kumar1, Subramani Karthikeyan1, Chandhrasegaran Ramprasad2, Prakasa Rao Aruna1, Narayanasamy Mathivanan2, Devadasan Velmurugan3,4, Singaravelu Ganesan1( )
Department of Medical Physics, Anna University, Chennai 600025, India
Centre for Advanced Studies in Botany, University of Madras, Chennai 600025, India
Centre of Advanced Study in Crystallography and Biophysics, University of Madras, Chennai 600025, India
Bioinformatics Infrastructure Facility, University of Madras, Chennai 600025, India
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Abstract

In this study, antimicrobial investigations for the efficiently synthesized biocompatible Phloroglucinol Succinic acid (PGSA) dendrimer with anionic surfaces were performed using broth dilution method against a Gram-positive bacterium (Staphylococcus aureus), a Gram-negative bacterium (Escherichia coli) and a fungal human pathogen (Candida albicans) to determine the minimal inhibitory concentration (MIC) value. Additionally, fluorescence and UV absorbance spectroscopy techniques were used to monitor the release of intracellular materials from the pathogens owing to anionic dendrimers. The exact binding sites of this dendrimer on these pathogens by molecular modelling studies motivated us to report this nanocarrier as a new antimicrobial agent.

Keywords

DendrimerAnti-microbialMolecular modellingBiocompatible polymersTryptophan

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Nano Biomedicine and Engineering
Volume 7 Issue 2,
June 2015
Pages 62-74
DOI: 10.5101/nbe.v7i2.p62-74
Cite this article:
Kumar MS, Karthikeyan S, Ramprasad C, et al. Investigation of Phloroglucinol Succinic Acid Dendrimer as Antimicrobial Agent Against Staphylococcus Aureus, Escherichia Coli and Candida Albicans. Nano Biomedicine and Engineering, 2015, 7(2): 62-74. https://doi.org/10.5101/nbe.v7i2.p62-74

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Received: 01 March 2015
Accepted: 10 June 2015
Published: 24 June 2015
© 2015 Murugesan Suresh Kumar, Subramani Karthikeyan, Chandhrasegaran Ramprasad, Prakasa Rao Aruna, Narayanasamy Mathivanan, Devadasan Velmurugan and Singaravelu Ganesan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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