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Research Article | Open Access

Metal-Assisted and Microwave-Accelerated Decrystallization

Yehnara S.B. Ettinoffe, Bridgit M. Kioko, Brittney I. Gordon, Nishone A. Thompson, Morenike Adebiyi, Kevin Mauge-Lewis, Taiwo O. Ogundolie, Enock Bonyi, Muzaffer Mohammed, Kadir Aslan( )
Morgan State University, Department of Chemistry, 1700 East Cold Spring Lane, Baltimore, MD 21251, USA
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Abstract

We present a platform technology, called Metal-Assisted and Microwave-Accelerated Decrystallization (MAMAD), which is based on the use of dispersion of gold colloids with low power microwave heating to decrystallize organic and biological crystals attached to surfaces. Uric acid crystals were chosen as model target crystals to be decrystallized using MAMAD technique. A two-step procedure was employed: 1) growth of uric acid crystals on a model surface (collagen films coated on to glass slides to simulate a human joint) at room temperature and 2) de-crystallization of uric acid crystals in synovial fluid (in vitro) using silver and gold colloids in conjunction with low power microwave heating. Using the MAMAD technique with gold colloids, the number of uric acid crystals was drastically reduced by 80% after 10 min, where the average size of the uric acid crystals was reduced from 125 μm to 50 μm. In control experiments and with silver colloids that aggregated from the solution, the size and number of uric crystals remained unchanged, indicating that the combined use of only metal colloids in solution and microwave heating is effective for the de-crystallization of uric acid crystals in biological media.

Keywords

Uric acidHyperuricaemiaCrystallizationGold colloidsSilver colloidsMedical microwavesMicrowave-induced temperature gradients

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Nano Biomedicine and Engineering
Volume 7 Issue 4,
December 2015
Pages 139-152
DOI: 10.5101/nbe.v7i4.p139-152
Cite this article:
Ettinoffe YS, Kioko BM, Gordon BI, et al. Metal-Assisted and Microwave-Accelerated Decrystallization. Nano Biomedicine and Engineering, 2015, 7(4): 139-152. https://doi.org/10.5101/nbe.v7i4.p139-152

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Received: 01 October 2015
Accepted: 07 December 2015
Published: 14 December 2015
© 2015 Yehnara S.B. Ettinoffe, Bridgit M. Kioko, Brittney I. Gordon, Nishone A. Thompson, Morenike Adebiyi, Kevin Mauge-Lewis, Taiwo O. Ogundolie, Enock Bonyi, Muzaffer Mohammed and Kadir Aslan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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