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Research Article | Open Access

Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging

Indu Venugopal1, Sebastian Pernal1, Taylor Fusinatto1,2, David Ashkenaz1,3, Andreas Linninger1( )
University of Illinois at Chicago, Department of Bioengineering, Laboratory for Product and Process Design
NSF-RET fellow from Bessie Rhodes Magnet School, Science Department
NSF-RET fellow from Innovations High School, Science Department
Show Author Information

Abstract

Nanotechnology is being increasingly applied for developing drug delivery options for specific treatments. Magnetic nanoparticles have drawn attention as drug delivery vehicles due to their stability, biocompatibility and ability to be non-invasively guided to desired target areas using magnetic fields. In this paper, we describe a new delivery vehicle for magnetic drug targeting. In magnetic drug targeting, drug functionalized magnetic nanoparticles are guided and localized at specific sites using external magnetic fields. Magnetic nanoparticles act as contrast agents for magnetic resonance imaging. However, it cannot be visualized via this technique during drug delivery. This is between magnetic fields used for imaging and delivery can interference with each other. Our laboratory has synthesized a magnetic drug targeting vehicle conjugated with quantum dots that can be imaged during the drug delivery process with in vivo imaging techniques such as fluorescence molecular tomography. These nanocomposites can be used as drug delivery vehicles for the central nervous system, where drug targeting is especially difficult and minimizing side effects is critical.

Keywords

Drug deliveryMagnetic nanoparticlesFluorescent nanoparticlesMagnetic drug targeting

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Nano Biomedicine and Engineering
Volume 8 Issue 1,
March 2016
Pages 24-38
DOI: 10.5101/nbe.v8i1.p24-38
Cite this article:
Venugopal I, Pernal S, Fusinatto T, et al. Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging. Nano Biomedicine and Engineering, 2016, 8(1): 24-38. https://doi.org/10.5101/nbe.v8i1.p24-38

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Received: 12 December 2015
Accepted: 18 February 2016
Published: 12 March 2016
© 2016 Indu Venugopal, Sebastian Pernal, Taylor Fusinatto, David Ashkenaz and Andreas Linninger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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