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Research Article | Open Access

Splenic Transcriptome Profiling of the Patients with Post-Hepatitis B Liver Cirrhosis and Portal Hypertension

Lingxiang Yu#, Xiaodong Guo#, Zhiwei Li, Shaogeng Zhang( )
Department of Hepatobiliary Surgery, 302 Hospital of PLA, Beijing 100039, PR China

#These authors contributed equally to this paper and should be regarded as co-first author

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Abstract

The infection with hepatitis B virus is the common cause of liver cirrhosis, and portal hypertensionis is one of the main causes of morbidity and mortality in patients with cirrhosis, which has attracted extensive attention for its fatal complications worldwide. By comparing the expression pattern to normal spleen tissues through RNA-Seq technology, we identified a list of protein-coding genes that were expressed differentially between patient and normal samples. Especially the secretory cytokines, including chemokine activity-related genes and immediate early response genes, were significantly upregulated in spleen samples. The results and genes identified in this study revealed the similar expression pattern in human samples to that reported in murine model, which further support the thesis that the spleen could take a harmful role and provide a negative impact in this situation due to inducing chemokine and transcription factor.

Keywords

Hepatitis BLiver cirrhosisPortal hypertensionTranscriptome sequencing

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Nano Biomedicine and Engineering
Volume 8 Issue 3,
September 2016
Pages 184-189
DOI: 10.5101/nbe.v8i3.p184-189
Cite this article:
Yu L, Guo X, Li Z, et al. Splenic Transcriptome Profiling of the Patients with Post-Hepatitis B Liver Cirrhosis and Portal Hypertension. Nano Biomedicine and Engineering, 2016, 8(3): 184-189. https://doi.org/10.5101/nbe.v8i3.p184-189

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Received: 19 September 2016
Accepted: 20 September 2016
Published: 28 September 2016
© 2016 Lingxiang Yu, Xiaodong Guo, Zhiwei Li and Shaogeng Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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