AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Nano Biomedicine and Engineering Article
PDF (1.9 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Review | Open Access

Surface Enhanced Raman Scattering (SERS): From Fundamental Mechanism to Bio-Analytics Tools

Xiao Zhi1, Li Lin1,2, Di Chen1( )
Institute of Nano Biomedicine and Engineering, Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, P. R. China
Show Author Information

Abstract

This review discusses the surface-enhanced Raman scattering (SERS) with efficiencies enhanced by as much as 1014-1015 fold as well as a SERS cross section on the order of 10-17-10-16 cm2/molecule. Despite the existing controversy on the origin of the enhancement, SERS effect offers new opportunities for spectroscopic detection of single molecules near or on the surface of metallic nanoparticles. There has been a considerable amount of research on explanation of the enhancement mechanism and on developing SERS labels as bio-analytics tools for either molecular multiplexed detection or bio-imaging at different levels.

Keywords

RamanSERSMachanismBio-analytics

References

[1]

S. Schlücker, SERS Microscopy: Nanoparticle Probes and Biomedical Applications. Chemphyschem, 2009. 10(9):1344-1354.
Crossref Google Scholar
[2]

M. Fleischmann, P.J. Hendra, and A. McQuillan, Raman spectra of pyridine adsorbed at a silver electrode. Chemical Physics Letters, 1974. 26(2):163-166.
Crossref Google Scholar
[3]

W.E. Doering, M.E. Piotti, M.J. Natan, et al., SERS as a foundation for nanoscale, optically detected biological labels. Adv Mater, 2007. 19(20):3100-3108.
Crossref Google Scholar
[4]

R.M. Jarvis, R. Goodacre, Characterisation and identification of bacteria using SERS. Chem Soc Rev, 2008. 37(5):931-936.
Crossref Google Scholar
[5]

W. Xie, P. Qiu, and C. Mao, Bio-imaging, detection and analysis by using nanostructures as SERS substrates. J Mater Chem, 2011. 21(14):5190-5202.
Crossref Google Scholar
[6]

J. Conde, C. Bao, D. Cui, et al., Antibody-drug gold nanoantennas with Raman spectroscopic fingerprints for in vivo tumour theranostics. J Controlled Release, 2014. 183:87-93.
Crossref Google Scholar
[7]

S. Chen, D. Liu, Z. Wang, et al., Picomolar detection of mercuric ions by means of gold-silver core-shell nanorods. Nanoscale, 2013. 5(15):6731-6735.
Crossref Google Scholar
[8]

M.J. Banholzer, J.E. Millstone, L. Qin, et al., Rationally designed nanostructures for surface-enhanced Raman spectroscopy. Chem Soc Rev, 2008. 37(5):885-897.
Crossref Google Scholar
[9]

S. Chen, P. Huang, Z. Wang, et al., Self-assembly of gold nanoparticles to silver microspheres as highly efficient 3D SERS substrates. Nanoscale Res Lett, 2013. 8.
Crossref Google Scholar
[10]
D.O. Ansari, Raman-encoded nanoparticles for biomolecular detection and cancer diagnostics. Georgia Institute of Technology, 2008.
[11]

A. Campion, P. Kambhampati, Surface-enhanced Raman scattering. Chem Soc Rev, 1998. 27(4):241-250.
Crossref Google Scholar
[12]

K. Kneipp, H. Kneipp, I. Itzkan, et al., Ultrasensitive chemical analysis by Raman spectroscopy. Chem Rev, 1999. 99(10):2957-2976.
Crossref Google Scholar
[13]

C.V. Raman, K.S. Krishnan, A new type of secondary radiation. Nature, 1928. 121:501-502.
Crossref Google Scholar
[14]

G. Landsberg, L. Mandelstam, A new occurrence in the light diffusion of crystals. Naturwissenschaften, 1928. 16:557-558.
Crossref Google Scholar
[15]

Y.X. Yuan, L. Ling, X.Y. Wang, et al., Surface enhanced Raman spectroscopic readout on heavy metal ions based on surface self assembly. J Raman Spectrosc, 2007. 38(10):1280-1287.
Crossref Google Scholar
[16]

K.A. Willets, R.P. Van Duyne, Localized surface plasmon resonance spectroscopy and sensing. Annual Review of Physical Chemistry, 2007. 58:267-297.
Crossref Google Scholar
[17]

S. Lal, S. Link, and N.J. Halas, Nano-optics from sensing to waveguiding. Nature Photonics, 2007. 1(11):641-648.
Crossref Google Scholar
[18]

A. McQuillan, P. Hendra, and M. Fleischmann, Raman spectroscopic investigation of silver electrodes. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1975. 65(2):933-944.
Crossref Google Scholar
[19]

D.L. Jeanmaire, R.P. Van Duyne, Surface Raman spectroelectrochemistry: Part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode. Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1977. 84(1):1-20.
Crossref Google Scholar
[20]

C.L. Haynes, C.R. Yonzon, X. Zhang, et al., Surface-enhanced Raman sensors: early history and the development of sensors for quantitative biowarfare agent and glucose detection. J Raman Spectrosc, 2005. 36(6-7):471-484.
Crossref Google Scholar
[21]

K. Kneipp, H. Kneipp, and J. Kneipp, Surface-enhanced Raman scattering in local optical fields of silver and gold nanoaggregates from single-molecule Raman spectroscopy to ultrasensitive probing in live cells. Acc Chem Res, 2006. 39(7):443-450.
Crossref Google Scholar
[22]
K. Kneipp, M. Moskovits, and H. Kneipp, Surface-enhanced Raman scattering: physics and applications, Vol. 103. Springer Science & Business Media, 2006.
Crossref
[23]

K. Kneipp, M. Moskovits, and H. Kneipp, Surface-enhanced Raman scattering. Physics Today, 2007. 60(11):40-46.
Crossref Google Scholar
[24]

K. Kneipp, Y. Wang, H. Kneipp, et al., Single molecule detection using surface-enhanced Raman scattering (SERS). Physical Review Letters, 1997. 78(9):1667.
Crossref Google Scholar
[25]

S. Nie, S.R. Emory, Probing single molecules and single nanoparticles by surface-enhanced Raman scattering. Science, 1997. 275(5303):1102-1106.
Crossref Google Scholar
[26]

K. Kneipp, H. Kneipp, P. Corio, et al., Surface-enhanced and normal Stokes and anti-Stokes Raman spectroscopy of single-walled carbon nanotubes. Physical Review Letters, 2000. 84(15):3470-3473.
Crossref Google Scholar
[27]

Y. Wang, L. Chen, Quantum dots, lighting up the research and development of nanomedicine. Nanomed Nanotechnol Biol Med, 2011. 7(4):385-402.
Crossref Google Scholar
[28]

Z. Li, Y. Xia, Metal nanoparticles with gain toward single-molecule detection by surface-enhanced Raman scattering. Nano Lett, 2009. 10(1):243-249.
Crossref Google Scholar
[29]

P.L. Stiles, J.A. Dieringer, N.C. Shah, et al., Surface-enhanced Raman spectroscopy. Annual Review of Analytical Chemistry, 2008. 1:601-626.
Crossref Google Scholar
[30]

Y. Wang, B. Yan, and L. Chen, SERS tags: novel optical nanoprobes for bioanalysis. Chem Rev, 2012. 113(3):1391-1428.
Crossref Google Scholar
[31]

T.M. Cotton, J.H. Kim, and G.D. Chumanov, Application of surface‐enhanced Raman spectroscopy to biological systems. J Raman Spectrosc, 1991. 22(12):729-742.
Crossref Google Scholar
[32]
E. Koglin, J.-M. Séquaris, Surface enhanced Raman scattering of biomolecules. Analytical Problems. Springer, 1986: 1-57.
Crossref
[33]

R. Paisley, M. Morris, Surface enhanced Raman spectroscopy of small biological molecules. Progress in Analytical Spectroscopy, 1988. 11(2):111-140.
Google Scholar
[34]

K. Kneipp, H. Kneipp, I. Itzkan, et al., Surface-enhanced Raman scattering: A new tool for biomedical spectroscopy. Curr Sci, 1999. 77(7):915-924.
Google Scholar
[35]

W.E. Doering, S. Nie, Single-molecule and single-nanoparticle SERS: examining the roles of surface active sites and chemical enhancement. The Journal of Physical Chemistry B, 2002. 106(2):311-317.
Crossref Google Scholar
[36]

J.A. Dieringer, R.B. Lettan, K.A. Scheidt, et al., A frequency domain existence proof of single-molecule surface-enhanced Raman spectroscopy. J Am Chem Soc, 2007. 129(51):16249-16256.
Crossref Google Scholar
[37]

S.R. Emory, R.A. Jensen, T. Wenda, et al., Re-examining the origins of spectral blinking in single-molecule and single-nanoparticle SERS. Faraday Discussions, 2006. 132:249-259.
Crossref Google Scholar
[38]

M. Moskovits, Surface-enhanced spectroscopy. Reviews of Modern Physics, 1985. 57(3):783-826.
Crossref Google Scholar
[39]

A.M. Michaels, M. Nirmal, and L. Brus, Surface enhanced Raman spectroscopy of individual rhodamine 6G molecules on large Ag nanocrystals. J Am Chem Soc, 1999. 121(43):9932-9939.
Crossref Google Scholar
[40]

X.M. Qian, S.M. Nie, Single-molecule and single-nanoparticle SERS: from fundamental mechanisms to biomedical applications. Chem Soc Rev, 2008. 37(5):912-920.
Crossref Google Scholar
[41]

R. Wang, C. Yu, F. Yu, et al., Molecular fluorescent probes for monitoring pH changes in living cells. TrAC, Trends Anal Chem, 2010. 29(9):1004-1013.
Crossref Google Scholar
[42]

Y. Chen, Y. Zhang, F. Pan, et al., Breath Analysis Based on Surface-Enhanced Raman Scattering Sensors Distinguishes Early and Advanced Gastric Cancer Patients from Healthy Persons. ACS Nano, 2016. 10(9):8169-8179.
Crossref Google Scholar
[43]

G.R. Souza, D.R. Christianson, F.I. Staquicini, et al., Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents. PNAS., 2006. 103(5):1215-1220.
Crossref Google Scholar
[44]

X. Huang, I.H. El-Sayed, W. Qian, et al., Cancer cells assemble and align gold nanorods conjugated to antibodies to produce highly enhanced, sharp, and polarized surface Raman spectra: a potential cancer diagnostic marker. Nano Lett, 2007. 7(6):1591-1597.
Crossref Google Scholar
[45]

Q. Hu, L.L. Tay, M. Noestheden, et al., Mammalian cell surface imaging with nitrile-functionalized nanoprobes: biophysical characterization of aggregation and polarization anisotropy in SERS imaging. J Am Chem Soc, 2007. 129(1):14-15.
Crossref Google Scholar
[46]

K.N. Yu, S.M. Lee, J.Y. Han, et al., Multiplex targeting, tracking, and imaging of apoptosis by fluorescent surface enhanced Raman spectroscopic dots. Bioconjugate Chemistry, 2007. 18(4):1155-1162.
Crossref Google Scholar
[47]

L. Wang, T. Guo, Q. Lu, et al., Sea-urchin-like Au nanocluster with surface-enhanced Raman scattering in detecting epidermal growth factor receptor (EGFR) mutation status of malignant pleural effusion. Acs Appl. Mater. Interfaces, 2015. 7(1):359-369.
Crossref Google Scholar
[48]

R.J. Dijkstra, W.J. Scheenen, N. Dam, et al., Monitoring neurotransmitter release using surface-enhanced Raman spectroscopy. J Neurosci Methods, 2007. 159(1):43-50.
Crossref Google Scholar
[49]

J. Kneipp, H. Kneipp, W.L. Rice, et al., Optical probes for biological applications based on surface-enhanced Raman scattering from indocyanine green on gold nanoparticles. Anal Chem, 2005. 77(8):2381-2385.
Crossref Google Scholar
[50]

F. Tian, J. Conde, C. Bao, et al., Gold nanostars for efficient in vitro and in vivo real-time SERS detection and drug delivery via plasmonic-tunable Raman/FTIR imaging. Biomaterials, 2016. 106:87-97.
Crossref Google Scholar
[51]

A. Michota, J. Bukowska, Surface-enhanced Raman scattering (SERS) of 4-mercaptobenzoic acid on silver and gold substrates. J Raman Spectrosc, 2003. 34(1):21-25.
Crossref Google Scholar
[52]

J. Kneipp, H. Kneipp, B. Wittig, et al., One-and two-photon excited optical pH probing for cells using surface-enhanced Raman and hyper-Raman nanosensors. Nano Lett, 2007. 7(9):2819-2823.
Crossref Google Scholar
Nano Biomedicine and Engineering
Volume 8 Issue 4,
December 2016
Pages 297-305
DOI: 10.5101/nbe.v8i4.p297-305
Cite this article:
Zhi X, Lin L, Chen D. Surface Enhanced Raman Scattering (SERS): From Fundamental Mechanism to Bio-Analytics Tools. Nano Biomedicine and Engineering, 2016, 8(4): 297-305. https://doi.org/10.5101/nbe.v8i4.p297-305

427

Views

6

Downloads

2

Crossref

3

Scopus

Altmetrics
Received: 09 December 2016
Accepted: 13 December 2016
Published: 26 December 2016
© 2016 Xiao Zhi, Li Lin, and Di Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Return