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Research Article | Open Access

Iridium-Based Dual-Functional Nanoparticles for Far-Red Imaging and Photodynamic Therapy

Lanying Guo1,2, Hongshang Peng1( ), Ruiying Shen2, Jiantao Ping1,2, Fangtian You2, Yiquan Wang1, Min Song1, Qu Zhen1
School of Science, Minzu University of China, Beijing 100081, China
Key Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, Beijing 100044, China
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Abstract

Phosphorescent iridium complexes ranged from far-red to NIR have attracted great attention as oxygen probes or photosensitizers recently. In this work, a far-red phosphorescent iridium complex ((DPQ)2Ir(acac)) was adopted to prepare biocompatible nanoparticles (Ir-NPs) for both phosphorescence imaging and photodynamic therapy of living cells. The iridium complex was highly sensitive to oxygen in organic solvent, but became less insensitive after being incorporated into NPs, though the particle matrix was highly permeable to oxygen. Moreover, the Ir-NPs exhibited a fast rate of singlet oxygen generation under 660 nm light irradiation. Taking advantage of these Ir-NPs, cellular imaging in the far-red range was realized; meanwhile, in vitro PDT was successfully performed. These results suggested that the Ir-NPs can function as both bio-imaging agents and nano-photosensitizers that work in the far red range.

Keywords

NanoparticlesFluorescence imagingPhotodynamic therapyOxygenIridium (Ⅲ) complex

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Nano Biomedicine and Engineering
Volume 9 Issue 1,
March 2017
Pages 1-8
DOI: 10.5101/nbe.v9i1.p1-8
Cite this article:
Guo L, Peng H, Shen R, et al. Iridium-Based Dual-Functional Nanoparticles for Far-Red Imaging and Photodynamic Therapy. Nano Biomedicine and Engineering, 2017, 9(1): 1-8. https://doi.org/10.5101/nbe.v9i1.p1-8

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Received: 03 November 2016
Accepted: 27 December 2016
Published: 19 January 2017
© 2017 Lanying Guo, Hongshang Peng, Ruiying Shen, Jiantao Ping, Fangtian You, Yiquan Wang, Min Song, and Qu Zhen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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