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Research Article | Open Access

Formulation of Mefenamic Acid Loaded Ethosomal Gel by Hot and Cold Methods

Regunta Supraja, Abbaraju Krishna Sailaja( )
RBVRR Women’s College of Pharmacy, Osmania University, Hyderabad, India
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Abstract

The aim of the present study is the formulation of mefenamic acid ethosomal gel by hot and cold methods. To prepare the mefenamic acid transdermal gel, ethosomes was selected as colloidal carriers. Ethosomes were prepared by cold and hot methods. The obtained ethosomes were characterized with vesicular diameter, zeta potential, drug content, entrapment efficiency and in-vitro diffusion studies. The five formulations of ethosomes prepared by cold and hot methods were compared. Among the 10 formulations of ethosomes, E5 was considered as the best formulation because of its mean vesicular diameter of 854 nm, zeta potential of 20 mV, drug content of 96.3%, entrapment efficiency of 94.4%, sustained drug release for 12 hr, i.e. 94.4. Then the E5 formulations was incorporated into gel. A comparative study was made between the plain gel and the ethosomal gel. The Ethosomal gel was considered the best because of its highest drug content spreadability , pH (6.9) and the sustained drug release profile for 12 hr. By comparison, the cold method shows better results.

Keywords

StabilityMefenamic acidEthosomesTransferosomesVesicular diameterEntapment efficiency

References

[1]

B. Nagadevi, K.S. Kumar, P. Venkanna, et al., Formulation and characterisation of tizanidine hydrochloride loaded ethosomes patch. International Journal of Pharmacy and Pharmaceutical Sciences, 2014, 6(4): 199-205.
Google Scholar
[2]

M. Irfan, S. Verma, and A. Ram., Preparation and characterization of ibuprofen loaded transferosome as a novel carrier for transdermal drug delivery system. Asian Journal of Pharmaceutical and Clinical Research, 2012, 5(3): 162-165.
Google Scholar
[3]

G. Cevc, G. Blume, New highly effcient formulation of diclofenac for the topical, transdermal administration in ultradeformable drug carriers, transfersomes. Biochimica et Biophysica Acta, 2001, 1514: 191-205.
Crossref Google Scholar
[4]

S. Duangjit, P. Opanasopit, T. Rojanarata, et al., Characterization and in vitro skin permeation of meloxicam-loaded liposomes versus transfersomes. Journal of Drug Delivery, 2011, 2011: 418316.
Crossref Google Scholar
[5]

Preeti, M.S. Kumar, Development of celecoxib transfersomal gel for the treatment of rheumatoid arthritis. Indian Journal of Pharmaceutical and Biological Research, 2014, 2(2): 7-13.
Crossref Google Scholar
[6]

C. Fan, X. Li, Y. Zhou, et al., Enhanced topical delivery of tetrandrine by ethosomes for treatment of arthritis. BioMed Research International, 2013, 2013: 161943.
Crossref Google Scholar
[7]

R.G.S. Maheshwari, R.K. Tekade, P.A. Sharma, et al., Ethosomes and ultradeformable liposomes for transdermaldelivery of clotrimazole: A comparative assessment. Saudi Pharmaceutical Journal, 2012, 20: 161-170.
Crossref Google Scholar
[8]

X. Liu, H. Liu, J. Liu, et al., Preparation of a ligustrazine ethosome patchand its evaluation in vitro and in vivo. International Journal of Nano medicine, 2011, 6: 241- 247.
Crossref Google Scholar
[9]

R. Bhana, A. Verma, and S. Jain, Development and characterization of ethosomes bearing losartan potassium. International Journal of Pharmacy and Pharmaceutical Sciences, 2013, 5(1): 35-40.
Google Scholar
[10]

B. Sujitha, B. Krishnamoorthy, and M. Muthukumaran, Formulation and evaluation of piroxicam loaded ethosomal gel for transdermal delivery. Int J Adv Pharm Gen Res, 2014, 2(1): 34-45.
Google Scholar
[11]

A.R. Rathore, H.Khambete and S. Jain., Preparation and characterization of repaglinide loaded ethosomal gel for the treatment of NIDDM. International Journal of Pharmaceutical & Biological Archives, 2013, 4(2): 385-390.
Google Scholar
[12]

S. Ghanbarzadeh, S. Aramil, Enhanced transdermal delivery of diclofenac sodium via conventional liposomes, ethosomes, and transfersomes. BioMed Research International, 2013, 2013: 616810.
Crossref Google Scholar
[13]

H.A. Benson, Transfersomes for transdermal drug delivery. Expert Opin. Drug Deliv., 2006, 3(6): 727-737.
Crossref Google Scholar
[14]

C. Hafer, R. Goble, P. Deering, et al., Formulation of interleukin-2 and interferon-alpha containing ultra-deformable carriers for potential transdermal application. Anticancer Res., 1999, 19(2c): 1505-1507.
Google Scholar
[15]

C. Gregor, G. Dieter, S. Juliane, et al., Ultra-flexible vesicles, transfersomes, have an extremely low pore penetration resistance and transport therapeutic amounts of insulin across the intact mammalian skin. Biophysica Acta, 1998, 1368: 201-215.
Crossref Google Scholar
[16]

D.M. Sheo, A. Shweta, C.D. Ram, et al., Transfersomes - a novel vesicular carrier for enhanced transdermal delivery of stavudine: development, characterization and performance evaluation. J. Scientific Speculations and Res, 2010, 1(1): 30-36.
Google Scholar
[17]

J. R. Walve, S. R. Bakliwal, B. R. Rane, et al., Transfersomes: a surrogated carrier for transdermal drug delivery system. International Journal of Applied Biology and Pharmaceutical Technology, 2011, 2(1): 201-214.
Google Scholar
[18]

S . Pandey, M. Goyani, V. Devmurari, et al., Transferosomes: a novel approach for transdermal drug delivery. Der Pharmacia Letter, 2009, 1(2): 143-150.
Google Scholar
[19]
N.K. Jain. Advances in controlled and novel drug delivery (first edition). CBS Publishers and Distributers, New Delhi, 2001: 426-451.
[20]

R. Patel, S.K. Singh, S. Singh, et al., Development and characterization of curcumin loaded transfersome for transdermal delivery. J. Pharm Sci. Res., 2009, 1(4): 71-80.
Google Scholar
[21]

D.M. Sheo, A. Shweta, K.T. Vijay, et al., Enhanced transdermal delivery of indinavir sulfate via transfersomes. Pharmacie Globale (IJCP), 2010, 1(6): 1-7.
Google Scholar
Nano Biomedicine and Engineering
Volume 9 Issue 1,
March 2017
Pages 27-35
DOI: 10.5101/nbe.v9i1.p27-35
Cite this article:
Supraja R, Krishna Sailaja A. Formulation of Mefenamic Acid Loaded Ethosomal Gel by Hot and Cold Methods. Nano Biomedicine and Engineering, 2017, 9(1): 27-35. https://doi.org/10.5101/nbe.v9i1.p27-35

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Received: 27 February 2017
Accepted: 16 March 2017
Published: 23 March 2017
© 2017 Regunta Supraja, Abbaraju Krishna Sailaja.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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