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Review | Open Access

Microfluidic Electrochemical Detection Techniques of Cancer Biomarkers

Yao Xie, Di Chen( ), Shujing Lin
Key Lab for Thin Film and Microfabrication Technology of Ministry of Education, Shanghai Intelligent Diagnosis and Treatment Instrument Engineering Technology Research Center, Department of Instrument Science and Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
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Abstract

Microfluidic electrochemical sensors are based on the immune response. Immune charge density or electrode potential and other parameters sensitive interface causes a change or cause a power solution of the active ingredient (or their related components) to generate or consume, causing the detected current or potential. The electrochemical parameters of the law of changing enable the immune proteins quantitative or qualitative detection. Since the immune protein molecules themselves are typically non-electrochemical activity, and therefore immune electrochemical sensor usually mark the electrically active substance or enzyme in the antigen or antibody molecules in solution antigen (antibody) immune response and by the immobilized antigen (antibody) the concentration of the sample antigen (antibody) after the change of the current signal, causing the electro-active substance or enzyme-catalyzed reaction of substrate reaction can be determined indirectly.

Keywords

MicrofluidicCancer biomarkersElelctrochemical detection

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Nano Biomedicine and Engineering
Volume 9 Issue 1,
March 2017
Pages 57-71
DOI: 10.5101/nbe.v9i1.p57-71
Cite this article:
Xie Y, Chen D, Lin S. Microfluidic Electrochemical Detection Techniques of Cancer Biomarkers. Nano Biomedicine and Engineering, 2017, 9(1): 57-71. https://doi.org/10.5101/nbe.v9i1.p57-71

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Received: 11 January 2017
Accepted: 28 February 2017
Published: 29 March 2017
© 2017 Yao Xie, Di Chen, and Shujing Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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