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Research Article | Open Access

A Comparative Study of Aspirin Loaded Bovine Serum Albumin Nanoparticles Prepared by Desolvation Technique Using Various Desolvating Agents

RBVRR Women's College of Pharmacy Affiliated to Osmania University, Hyderabad, India
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Abstract

Aspirin is mainly used in the treatment of rheumatoid arthtitis and ankylosing spondylitis (AS). The dose of aspirin required for the treatment is 3 g / day in divided doses. In order to avoid chances of missing the dose of drug, it is better to formulate sustained release dosage forms. In the present study, aspirin loaded bovine serum albumin (BSA) nanoparticles were prepared by desolvation technique using various desolvating agents such as acetone, ethanol and sodium sulphate. A comparative study was made among the three desolvating agents (acetone, ethanol and sodium sulphate) and two methods (continuous addition method and intermittent addition method) to decide the best desolvating agent and the better method for preparation of aspirin nanoparticles by desolvation method. Continuous and intermittent addition methods were followed for the addition of desolvating agent to the aqueous solution of bovine serum albumin. Bovine serum albumin nanoparticles prepared by intermittent addition of ethanol was showing better results with the mean particle diameter of 209 nm, entrapment efficiency of 50% and loading capacity of 23%. The drug release was slow, extending over a period of 24 h. The curve fitting data revealed that the release followed the first-order kinetics. Higuchis and Peppas plots stated that Fickian diffusion controlled the pattern in all formulations. From the results it can be concluded that the method of intermittent addition was the better method and ethanol was the best desolvating agent for the preparation of aspirin nanoparticles by desolvation technique.

Keywords

Desolvation techniqueContinuous addition methodIntermittent addition methodScanning electron microscopeZeta potential

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Nano Biomedicine and Engineering
Volume 9 Issue 2,
June 2017
Pages 143-151
DOI: 10.5101/nbe.v9i2.p143-151
Cite this article:
Sailaja AK. A Comparative Study of Aspirin Loaded Bovine Serum Albumin Nanoparticles Prepared by Desolvation Technique Using Various Desolvating Agents. Nano Biomedicine and Engineering, 2017, 9(2): 143-151. https://doi.org/10.5101/nbe.v9i2.p143-151

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Received: 17 April 2017
Accepted: 02 June 2017
Published: 19 June 2017
© 2017 Abbaraju Krishna Sailaja.

This is an openaccess article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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