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Research Article | Open Access

The Effect of the Nano-Drug Carbomicin Inhibiting the Relapse of Stomach Cancer after Radiofrequency Ablation

Yueting Li1, Baoquan Zhao2( ), Yunzhu Pu2, Weitong Pan3, Xiaoman Li2, Yuxia Wang2, Yongan Wang2, Lan Sun2, Chunqian Huang2, Qian Li2, Yingge Zhang2( )
Department of Surgery, Beijing Hospital of Integrated Traditional and Western Medicine, Beijing 100039, PR China
State Key Laboratory of Toxicology and Medical Countermeasures, Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing 100850, PR China
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China
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Abstract

Radiofrequency ablation (RFA) is a promising tumor treatment in clinics, but its use is limited given the high post-RFA recurrence rate. To overcome tumor relapse, RFA needs to be used in combination with a long-lasting treatment. Obviously, the focal injection of antitumor drugs is capable of increasing the effective treatment period. Nano drug delivery systems (NDDS), which allow for a controlled and slow release of drugs, provide a promising strategy to overcome post-RFA tumor recurrence. Our results showed a clear transit area, between the non-ablation tumor area and the ablation necrotic area, indicative of apparent histopathological partition. Focal injection of the NDDS in combination with focally-injected carbomicin (CBMC) is an effective assistant treatment for RFA, as it increases efficiency and inhibits tumor relapse. Focally injected CBMC is a novel strategy which overcomes the disadvantages of RFA and may even cure it.

Keywords

Radiofrequency ablationTumor treatmentActive carbon nanoparticlesNano drug delivery systemTumor recurrence

References

[1]

American Cancer Society. Cancer Facts and Figures 2013. American Cancer Society, 2013.
[2]

S. Rossi, F. Fornari, and L. Buscarini, Percutaneous ultrasound-guided radiofrequency electrocautery for the treatment of small hepatocellular carcinoma. Journal of Interventional Radiology, 1993, 8(3): 97-103.
Google Scholar
[3]

C.H. Yuan, D.R. Xiu, H.Y. Ge, et al., Ultrasound guided ablation therapy of hepatic colorectal metastases: initial experience of real time virtual sonography navigation system. Beijing Da Xue Xue Bao, 2013, 45(6): 956-959.
Google Scholar
[4]

A.H. Lay, J. Stewart, N.E. Canvasser, et al., Likelihood of incomplete kidney tumor ablation with radio frequency energy: Degree of enhancement matters. J Urol, 2016, 196(1): 41-45.
Crossref Google Scholar
[5]

D. Chudasama, A. Rice, V. Anikin, et al., Circulating tumour cells in patients with malignant lung tumors undergoing radio-frequency ablation. Anticancer Res, 2015, 35(5): 2823-2826.
Google Scholar
[6]

T. Nakazawa, S. Kokubu, A. Shibuya, et al., Radiofrequency ablation of hepatocellular carcinoma: correlation between local tumor progression after ablation and ablative margin. AJR Am J Roentgenol, 2007, 188(2): 480-488.
Crossref Google Scholar
[7]

Y. Inoue, J. Hiro, Y. Toiyama, et al., Optimal use of current chemotherapy in multimodality therapy for advanced colorectal cancer. Oncol Lett, 2012, 3(2): 363-368.
Crossref Google Scholar
[8]

I. Smith, M. Kahaleh, Biliary Tumor ablation with photodynamic therapy and radiofrequency ablation. Gastrointest Endosc Clin N Am, 2015, 25(4): 793-804.
Crossref Google Scholar
[9]

M. Nikfarjam, V. Muralidharan, and C. Christophi, Mechanisms of focal heat destruction of liver tumors. J Surg Res, 2005, 127(2): 208-223.
Crossref Google Scholar
[10]

S. McDermott, D.A. Gervais, Radiofrequency Ablation of liver tumors. Seminars in Interventional Radiology, 2013, 30(1): 49-55.
Crossref Google Scholar
[11]

Z. Lu, M. Tsai, D. Lu, et al., Tumor-penetrating microparticles for intraperitoneal therapy of ovarian cancer. J Pharmacol Exp Ther, 2008, 327(3): 673-682.
Crossref Google Scholar
[12]

G.R. Dakwar, E. Zagato, J. Delanghe, et al., Colloidal stability of nano-sized particles in the peritoneal fluid: towards optimizing drug delivery systems for intraperitoneal therapy. Acta Biomater, 2014, 10(7): 2965-2975.
Crossref Google Scholar
[13]

O.M. Sarhan, R.M. Hussein, Effects of intraperitoneally injected silver nanoparticles on histological structures and blood parameters in the albino rat. Int J Nanomedicine, 2014, 9: 1505-1517.
Crossref Google Scholar
[14]

D. Cui, L. Ma, X. Zhi, et al., Advances and prospects of nanotheranostic technology for gastric cancer. Nano Biomedicine and Engineering, 2016, 8(4): 219-239.
Crossref Google Scholar
[15]

H. Fu, New developments of gastric cancer biomarker research. Nano Biomedicine and Engineering, 2016, 8(4): 268-273.
Crossref Google Scholar
[16]

K. Inoue, H. Onishi, Y. Kato, et al., Comparison of intraperitoneal continuous infusion of floxuridine and bolus administration in a peritoneal gastric cancer xenograft model. Cancer Chemother Pharmacol, 2004, 53(5): 415-422.
Crossref Google Scholar
[17]

O. Stoeltzing, W. Liu, N. Reinmuth, et al., Inhibition of integrin alpha5beta1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int J Cancer, 2003, 104(4): 496-503.
Crossref Google Scholar
[18]

J. Fujiyama, Y. Nakase, K. Osaki, et al., Cisplatin incorporated in microspheres: development and fundamental studies for its clinical application. J Control Release, 2003, 89(3): 397-408.
Crossref Google Scholar
[19]

L. De Smet, W. Ceelen, J.P. Remon, et al., Optimization of drug delivery systems for intraperitoneal therapy to extend the residence time of the chemotherapeutic agent. Scientific World Journal, 2013, 2013: 720858.
Crossref Google Scholar
[20]

Z.L. Feng, L.B. Chen, Z.Y. Liu, et al., DCF intraperitoneal and intravenous dual chemotherapy regimen for advanced gastric cancer: A feasibility study. Oncol Lett, 2015, 9(1): 491-497.
Crossref Google Scholar
[21]

N. Gould, M.W. Sill, R.S. Mannel, et al., A phase I study with an expanded cohort to assess feasibility of intravenous docetaxel, intraperitoneal carboplatin and intraperitoneal paclitaxel in patients with previously untreated ovarian, fallopian tube or primary peritoneal carcinoma: A gynecologic oncology group study. Gynecol Oncol, 2012, 127(3): 506-510.
Crossref Google Scholar
[22]

J. Xie, Y. Yong, X. Dong, et al., Therapeutic nanoparticles based on curcumin and bamboo charcoal nanoparticles for chemo-photothermal synergistic treatment of cancer and radioprotection of normal cells. ACS Appl Mater Interfaces, 2017, 9(16): 14281-14291.
Crossref Google Scholar
[23]

S.K. Lai, D.E. O'Hanlon, S. Harrold, et al., Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus. Proc Natl Acad Sci USA, 2007, 104(5): 1482-1487.
Crossref Google Scholar
[24]

A.W. Carpenter, D.L. Slomberg, K.S. Rao, et al., Influence of scaffold size on bactericidal activity of nitric oxide-releasing silica nanoparticles. ACS Nano, 2011, 5(9): 7235-7244.
Crossref Google Scholar
[25]

F. Gentile, A. Curcio, C. Indolfi, et al., The margination propensity of spherical particles for vascular targeting in the microcirculation. J Nanobiotechnology, 2008, 6: 9.
Crossref Google Scholar
[26]

E.A. Nance, G.F. Woodworth, K.A. Sailor, et al., A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue. Sci Transl Med, 2012, 4(149): 149ra119.
Crossref Google Scholar
[27]

H. Iwasa, H. Kondo, Differences in the width of the intercellular spaces in the epithelial basal infolding and the renal glomerular filtration site between freeze-substitution and conventional fixation. J Anat, 1999, 194(Pt 2): 215-221.
Crossref Google Scholar
[28]

H. Sarin, Physiologic upper limits of pore size of different blood capillary types and another perspective on the dual pore theory of microvascular permeability. J Angiogenes Res, 2010, 2: 14.
Crossref Google Scholar
[29]

D. Lembo, R. Cavalli, Nanoparticulate delivery systems for antiviral drugs. Antivir Chem Chemother, 2010, 21(2): 53-70.
Crossref Google Scholar
[30]

I.I. Slowing, J.L. Vivero-Escoto, C.W. Wu, et al., Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers. Adv Drug Deliv Rev, 2008, 60(11): 1278-1288.
Crossref Google Scholar
[31]

Y.T. Liao, C.H. Liu, J. Yu, et al., Liver cancer cells: targeting and prolonged-release drug carriers consisting of mesoporous silica nanoparticles and alginate microspheres. Int J NanomedicineI, 2014, 9: 2767-2778.
Crossref Google Scholar
[32]

J.L. Vivero-Escoto, I.I. Slowing, B.G. Trewyn, et al., Mesoporous silica nanoparticles for intracellular controlled drug delivery. Small, 2010, 6(18): 1952-1967.
Crossref Google Scholar
[33]

D.K. Armstrong, G.F. Fleming, M. Markman, et al., A phase I trial of intraperitoneal sustained-release paclitaxel microspheres (Paclimer) in recurrent ovarian cancer: A gynecologic oncology group study. Gynecol Oncol, 2006, 103(2): 391-396.
Crossref Google Scholar
[34]

Y.L. Colson, R. Liu, E.B. Southard, et al., The performance of expansile nanoparticles in a murine model of peritoneal carcinomatosis. Biomaterials, 2011, 32(3): 832-840.
Crossref Google Scholar
[35]

Q. Qiulian, Z. Yingge, Y. Liuzhong, et al., Intraperitoneal chemotherapy with mitomycin C bound to activated carbon nanoparticles for nude m ice bearing human gastric carcinoma. Chin J Oncol, 2006, 28(4): 257-260.
Google Scholar
[36]

Y. Liuzhong, Z. Yingge, Pharmacokinetic study of intraperitoneal chemotherapy with mitomycin C absorbed to activated carbon particles in rats. Chin J Cancer Prev Treat, 2008, 15(20): 1548-1551.
Google Scholar
[37]

T. Shimizu, S. Murata, H. Sonoda, et al., Hyperthermic intraperitoneal chemotherapy with mitomycin C and 5-fluorouracil in patients at high risk of peritoneal metastasis from colorectal cancer: A preliminary clinical study. Mol Clin Oncol, 2014, 2(3): 399-404.
Crossref Google Scholar
[38]

B. Zhao, L. Sun, W. Zhang, et al., Secretion of intestinal goblet cells: a novel excretion pathway of nanoparticles. Nanomedicine, 2014, 10(4): 839-849.
Crossref Google Scholar
[39]

M. Kudo, Local ablation therapy for hepatocellular carcinoma: current status and future perspectives. J Gastroenterol, 2004, 39(3): 205-214.
Crossref Google Scholar
[40]

Y.-T. Li, C. Nie, W.-T. Pan, et al., Effects of radiofrequency ablation on growing status of tumor cells around the focus of ablation, Journal of International Pharmaceutical Research, 2013, 40(5): 599-604.
Google Scholar
[41]

Z. Liu, J.T. Robinson, X. Sun, et al., PEGylated nanographene oxide for delivery of water-insoluble cancer drugs. J Am Chem Soc, 2008, 130(33):10876-10877.
Crossref Google Scholar
[42]

Z. Yang, S.-Z. Ma, and Y.-G. Zhang, Using activated carbon nanoparticles to decrease the genotoxicity and teratogenicity of anticancer therapeutic agents. J Nanosci Nanotechnol, 2010, 10(12): 8603-8609.
Crossref Google Scholar
[43]

R. Yeung, Y. McConnell, G. Roxin, et al., One compared with two cycles of mitomycin C in chemoradiotherapy for anal cancer: Analysis of outcomes and toxicity, Curr Oncol, 2014, 21(3): e449-456.
Crossref Google Scholar
Nano Biomedicine and Engineering
Volume 9 Issue 4,
December 2017
Pages 344-354
DOI: 10.5101/nbe.v9i4.p344-354
Cite this article:
Li Y, Zhao B, Pu Y, et al. The Effect of the Nano-Drug Carbomicin Inhibiting the Relapse of Stomach Cancer after Radiofrequency Ablation. Nano Biomedicine and Engineering, 2017, 9(4): 344-354. https://doi.org/10.5101/nbe.v9i4.p344-354

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Received: 20 December 2017
Accepted: 24 December 2017
Published: 30 December 2017
© Yueting Li, Baoquan Zhao, Yunzhu Pu, Weitong Pan, Xiaoman Li, Yuxia Wang, Yongan Wang, Lan Sun, Chunqian Huang, Qian Li, and Yingge Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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