AI Chat Paper
Discover the SciOpen Platform and Achieve Your Research Goals with Ease.
Fluorescence microscopy has become a routine tool in biology for interrogating life activities with minimal perturbation. While the resolution of fluorescence microscopy is in theory governed only by the diffraction of light, the resolution obtainable in practice is also constrained by the presence of optical aberrations. The past two decades have witnessed the advent of super-resolution microscopy that overcomes the diffraction barrier, enabling numerous biological investigations at the nanoscale. Adaptive optics, a technique borrowed from astronomical imaging, has been applied to correct for optical aberrations in essentially every microscopy modality, especially in super-resolution microscopy in the last decade, to restore optimal image quality and resolution. In this review, we briefly introduce the fundamental concepts of adaptive optics and the operating principles of the major super-resolution imaging techniques. We highlight some recent implementations and advances in adaptive optics for active and dynamic aberration correction in super-resolution microscopy.
Ahn C, Hwang B, Nam K, Jin H, Woo T, Park JH (2019) Overcoming the penetration depth limit in optical microscopy: adaptive optics and wavefront shaping. J Innov Opt Health Sci 12: 1930002
Angibaud J, Mascalchi P, Poujol C, Nagerl UV (2020) A simple tissue clearing method for increasing the depth penetration of STED microscopy of fixed brain slices. J Phys D-Appl Phys 53: 184001
Antonello J, Barbotin A, Chong EZ, Rittscher J, Booth MJ (2020a) Multi-scale sensorless adaptive optics: application to stimulated emission depletion microscopy. Opt Express 28: 16749−16763
Antonello J, Burke D, Booth MJ (2017) Aberrations in stimulated emission depletion (STED) microscopy. Opt Commun 404: 203−209
Antonello J, Kromann EB, Burke D, Bewersdorf J, Booth MJ (2016) Coma aberrations in combined two- and three-dimensional STED nanoscopy. Opt Lett 41: 3631−3634
Antonello J, Wang J, He C, Phillips M, Booth M (2020b) Interferometric calibration of a deformable mirror. Zenodo
Arigovindan M, Sedat JW, Agard DA (2012) Effect of depth dependent spherical aberrations in 3D structured illumination microscopy. Opt Express 20: 6527−6541
Baddeley D, Bewersdorf J (2018) Biological insight from super-resolution microscopy: what we can learn from localization-based images. Annu Rev Biochem 87: 965−989
Bancelin S, Mercier L, Murana E, Nägerl UV (2021) Aberration correction in stimulated emission depletion microscopy to increase imaging depth in living brain tissue. Neurophotonics 8(3): 035001
Banerjee K, Rajaeipour P, Ataman C, Zappe H (2018) Optofluidic adaptive optics. Appl Opt 57: 6338−6344
Belthangady C, Royer LA (2019) Applications, promises, and pitfalls of deep learning for fluorescence image reconstruction. Nat Methods 16: 1215−1225
Blom H, Widengren J (2017) Stimulated emission depletion microscopy. Chem Rev 117: 7377−7427
Booth M, Andrade D, Burke D, Patton B, Zurauskas M (2015) Aberrations and adaptive optics in super-resolution microscopy. Microscopy (Oxf) 64: 251−261
Booth MJ (2014) Adaptive optical microscopy: the ongoing quest for a perfect image. Light-Sci Appl 3 : e165−e165
Burke D, Patton B, Huang F, Bewersdorf J, Booth MJ (2015) Adaptive optics correction of specimen-induced aberrations in single-molecule switching microscopy. Optica 2: 177−185
Cabriel C, Bourg N, Dupuis G, Leveque-Fort S (2018) Aberration-accounting calibration for 3D single-molecule localization microscopy. Opt Lett 43: 174−177
Carlini L, Holden SJ, Douglass KM, Manley S (2015) Correction of a depth-dependent lateral distortion in 3D super-resolution imaging. PLoS One 10: e0142949
Chiu CP, Chiang TJ, Chen JK, Chang FC, Ko FH, Chu CW, Kuo SW, Fan SK (2012) Liquid lenses and driving mechanisms: a review. J Adhesion Sci Technol 26: 1773−1788
Coles BC, Webb SE, Schwartz N, Rolfe DJ, Martin-Fernandez M, Lo Schiavo V (2016) Characterisation of the effects of optical aberrations in single molecule techniques. Biomed Opt Express 7: 1755−1767
Dai Y, Antonello J, Booth MJ (2019) Calibration of a phase-only spatial light modulator for both phase and retardance modulation. Opt Express 27: 17912−17926
Debarre D, Botcherby EJ, Booth MJ, Wilson T (2008) Adaptive optics for structured illumination microscopy. Opt Express 16: 9290−9305
Deng S, Liu L, Cheng Y, Li R, Xu Z (2009) Investigation of the influence of the aberration induced by a plane interface on STED microscopy. Opt Express 17: 1714−1725
Deng S, Liu L, Cheng Y, Li R, Xu Z (2010) Effects of primary aberrations on the fluorescence depletion patterns of STED microscopy. Opt Express 18: 1657−1666
Deng Y, Shaevitz JW (2009) Effect of aberration on height calibration in three-dimensional localization-based microscopy and particle tracking. Appl Opt 48: 1886−1890
Gorlitz F, Guldbrand S, Runcorn TH, Murray RT, Jaso-Tamame AL, Sinclair HG, Martinez-Perez E, Taylor JR, Neil MAA, Dunsby C, French PMW (2018) easySLM-STED: stimulated emission depletion microscopy with aberration correction, extended field of view and multiple beam scanning. J Biophotonics 11: e201800087
Gould TJ, Burke D, Bewersdorf J, Booth MJ (2012) Adaptive optics enables 3D STED microscopy in aberrating specimens. Opt Express 20: 20998−21009
Gould TJ, Kromann EB, Burke D, Booth MJ, Bewersdorf J (2013) Auto-aligning stimulated emission depletion microscope using adaptive optics. Opt Lett 38: 1860−1862
Hacker M, Stobrawa G, Sauerbrey R, Buckup T, Motzkus M, Wildenhain M, Gehner A (2003) Micromirror SLM for femtosecond pulse shaping in the ultraviolet. Appl Phys B-Lasers Opt 76: 711−714
Hao X, Allgeyer ES, Lee D-R, Antonello J, Watters K, Gerdes JA, Schroeder LK, Bottanelli F, Zhao J, Kidd P, Lessard MD, Rothman JE, Cooley L, Biederer T, Booth MJ, Bewersdorf J (2021) Three-dimensional adaptive optical nanoscopy for thick specimen imaging at sub-50-nm resolution. Nat Methods 18: 688−693
Heintzmann R, Huser T (2017) Super-resolution structured illumination microscopy. Chem Rev 117: 13890−13908
Hu L, Hu S, Gong W, Si K (2019) Learning-based Shack-Hartmann wavefront sensor for high-order aberration detection. Opt Express 27: 33504−33517
Hu SW, Hu LJ, Gong W, Li ZH, and Si K (2021) Deep learning based wavefront sensor for complex wavefront detection in adaptive optical microscopes. Front Inform TechnolElectron Eng
Izeddin I, El Beheiry M, Andilla J, Ciepielewski D, Darzacq X, Dahan M (2012) PSF shaping using adaptive optics for three-dimensional single-molecule super-resolution imaging and tracking. Opt Express 20: 4957−4967
Ji N (2017) Adaptive optical fluorescence microscopy. Nat Methods 14: 374−380
Lenz MO, Sinclair HG, Savell A, Clegg JH, Brown AC, Davis DM, Dunsby C, Neil MA, French PM (2014) 3-D stimulated emission depletion microscopy with programmable aberration correction. J Biophotonics 7: 29−36
Li Y, Wu YL, Hoess P, Mund M, Ries J (2019) Depth-dependent PSF calibration and aberration correction for 3D single-molecule localization. Biomed Opt Express 10: 2708−2718
Lin R, Kipreos ET, Zhu J, Khang CH, Kner P (2021) Subcellular three-dimensional imaging deep through multicellular thick samples by structured illumination microscopy and adaptive optics. Nat Commun 12: 3148
Liu S, Kromann EB, Krueger WD, Bewersdorf J, Lidke KA (2013) Three dimensional single molecule localization using a phase retrieved pupil function. Opt Express 21: 29462−29487
Liu X, Tu SJ, Xu Y, Song HY, Liu WJ, Liu QL, Kuang CF, Liu X, Hao X (2020) Aberrations in structured illumination microscopy: a theoretical analysis. Front Phys
Mahajan VN (1994) Zernike circle polynomials and optical aberrations of systems with circular pupils. Appl Opt 33: 8121
McGorty R, Schnitzbauer J, Zhang W, Huang B (2014) Correction of depth-dependent aberrations in 3D single-molecule localization and super-resolution microscopy. Opt Lett 39: 275−278
Mertz J, Paudel H, Bifano TG (2015) Field of view advantage of conjugate adaptive optics in microscopy applications. Appl Opt 54: 3498−3506
Mlodzianoski MJ, Cheng-Hathaway PJ, Bemiller SM, McCray TJ, Liu S, Miller DA, Lamb BT, Landreth GE, Huang F (2018) Active PSF shaping and adaptive optics enable volumetric localization microscopy through brain sections. Nat Methods 15: 583−586
Mockl L, Moerner WE (2020) Super-resolution microscopy with single molecules in biology and beyond-essentials, current trends, and future challenges. J Am Chem Soc 142: 17828−17844
Nishizaki Y, Valdivia M, Horisaki R, Kitaguchi K, Saito M, Tanida J, Vera E (2019) Deep learning wavefront sensing. Opt Express 27: 240−251
Park JH, Kong L, Zhou Y, Cui M (2017) Large-field-of-view imaging by multi-pupil adaptive optics. Nat Methods 14: 581−583
Park JH, Sun W, Cui M (2015) High-resolution in vivo imaging of mouse brain through the intact skull. Proc Natl Acad Sci USA 112: 9236−9241
Patton BR, Burke D, Owald D, Gould TJ, Bewersdorf J, Booth MJ (2016) Three-dimensional STED microscopy of aberrating tissue using dual adaptive optics. Opt Express 24: 8862−8876
Pozzi P, Quintavalla M, Wong AB, Borst JGG, Bonora S, Verhaegen M (2020) Plug-and-play adaptive optics for commercial laser scanning fluorescence microscopes based on an adaptive lens. Opt Lett 45: 3585−3588
Prakash K, Diederich B, Reichelt S, Heintzmann R, Schermelleh L (2021) Super-resolution structured illumination microscopy: past, present and future. Philos Trans A Math Phys Eng Sci 379: 20200143
Rodriguez C, Ji N (2018) Adaptive optical microscopy for neurobiology. Curr Opin Neurobiol 50: 83−91
Saha D, Schmidt U, Zhang Q, Barbotin A, Hu Q, Ji N, Booth MJ, Weigert M, Myers EW (2020) Practical sensorless aberration estimation for 3D microscopy with deep learning. Opt Express 28: 29044−29053
Sahl SJ, Hell SW, Jakobs S (2017) Fluorescence nanoscopy in cell biology. Nat Rev Mol Cell Biol 18: 685−701
Sauer M, Heilemann M (2017) Single-molecule localization microscopy in eukaryotes. Chem Rev 117: 7478−7509
Schermelleh L, Ferrand A, Huser T, Eggeling C, Sauer M, Biehlmaier O, Drummen GPC (2019) Super-resolution microscopy demystified. Nat Cell Biol 21: 72−84
Siemons M, Hulleman CN, Thorsen RO, Smith CS, and Stallinga S (2018) High precision wavefront control in point spread function engineering for single emitter localization. Opt Express 26: 8397−8416
Siemons ME, Hanemaaijer NAK, Kole MHP, Kapitein LC (2021) Robust adaptive optics for localization microscopy deep in complex tissue. Nat Commun 12(1): 3407
Sigal YM, Zhou R, Zhuang X (2018) Visualizing and discovering cellular structures with super-resolution microscopy. Science 361: 880−887
Sulai YN, Dubra A (2014) Non-common path aberration correction in an adaptive optics scanning ophthalmoscope. Biomed Opt Express 5(9): 3059−3073
Tehrani KF, Xu J, Zhang Y, Shen P, Kner P (2015) Adaptive optics stochastic optical reconstruction microscopy (AO-STORM) using a genetic algorithm. Opt Express 23: 13677−13692
Tehrani KF, Zhang Y, Shen P, Kner P (2017) Adaptive optics stochastic optical reconstruction microscopy (AO-STORM) by particle swarm optimization. Biomed Opt Express 8: 5087−5097
Thomas B, Wolstenholme A, Chaudhari SN, Kipreos ET, Kner P (2015) Enhanced resolution through thick tissue with structured illumination and adaptive optics. J Biomed Opt 20: 26006
Tian L, Hunt B, Bell MAL, Yi J, Smith JT, Ochoa M, Intes X, Durr NJ (2021) Deep learning in biomedical optics. Lasers Surg Med
Turcotte R, Liang Y, Tanimoto M, Zhang Q, Li Z, Koyama M, Betzig E, Ji N (2019) Dynamic super-resolution structured illumination imaging in the living brain. Proc Natl Acad Sci USA 116: 9586−9591
Urban NT, Willig KI, Hell SW, Nagerl UV (2011) STED nanoscopy of actin dynamics in synapses deep inside living brain slices. Biophys J 101: 1277−1284
Velasco MGM, Zhang MY, Antonello J, Yuan P, Allgeyer ES, May D, M'Saad O, Kidd P, Barentine AES, Greco V, Grutzendler J, Booth MJ, Bewersdorf J (2021) 3D super-resolution deep-tissue imaging in living mice. Optica 8: 442−450
Vicidomini G, Bianchini P, Diaspro A (2018) STED super-resolved microscopy. Nat Methods 15: 173−182
von Diezmann A, Lee MY, Lew MD, Moerner WE (2015) Correcting field-dependent aberrations with nanoscale accuracy in three-dimensional single-molecule localization microscopy. Optica 2: 985−993
Wahl DJ, Zhang P, Mocci J, Quintavalla M, Muradore R, Jian Y, Bonora S, Sarunic MV, Zawadzki RJ (2019) Adaptive optics in the mouse eye: wavefront sensing based vs. image-guided aberration correction. Biomed Opt Express 10: 4757−4774
Wang Z, Cai Y, Liang Y, Dan D, Yao B, Lei M (2018) Aberration correction method based on double-helix point spread function. J Biomed Opt 24: 1−11
Wright AJ, Burns D, Patterson BA, Poland SP, Valentine GJ, Girkin JM (2005) Exploration of the optimisation algorithms used in the implementation of adaptive optics in confocal and multiphoton microscopy. Microsc Res Tech 67: 36−44
Wu Y, Shroff H (2018) Faster, sharper, and deeper: structured illumination microscopy for biological imaging. Nat Methods 15: 1011−1019
Xu F, Ma D, MacPherson KP, Liu S, Bu Y, Wang Y, Tang Y, Bi C, Kwok T, Chubykin AA, Yin P, Calve S, Landreth GE, Huang F (2020) Three-dimensional nanoscopy of whole cells and tissues with in situ point spread function retrieval. Nat Methods 17: 531−540
Zdankowski P, McGloin D, Swedlow JR (2019) Full volume super-resolution imaging of thick mitotic spindle using 3D AO STED microscope. Biomed Opt Express 10: 1999−2009
Zdankowski P, Trusiak M, McGloin D, Swedlow JR (2020) Numerically enhanced stimulated emission depletion microscopy with adaptive optics for deep-tissue super-resolved imaging. ACS Nano 14: 394−405
Zhang P, Liu S, Chaurasia A, Ma D, Mlodzianoski MJ, Culurciello E, Huang F (2018) Analyzing complex single-molecule emission patterns with deep learning. Nat Methods 15: 913−916
Zhang Y, Wu C, Song Y, Si K, Zheng Y, Hu L, Chen J, Tang L, Gong W (2019) Machine learning based adaptive optics for doughnut-shaped beam. Opt Express 27: 16871−16881
Zheng W, Wu Y, Winter P, Shroff H (2018) Adaptive optics improves multiphoton super-resolution imaging. Proceedings Volume 10502, Adaptive Optics and Wavefront Control for Biological Systems IV
Zheng Y, Chen J, Wu C, Gong W, Si K (2021) Adaptive optics for structured illumination microscopy based on deep learning. Cytometry A 99: 622−631
Zurauskas M, Dobbie IM, Parton RM, Phillips MA, Gohler A, Davis I, Booth MJ (2019) IsoSense: frequency enhanced sensorless adaptive optics through structured illumination. Optica 6: 370−379
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
