Intestinal Organoids: A New Tool for Infection Assessment of Foodborne Pathogens from Meat and Meat Products
Abstract
Meat and meat products are an essential part of the human diet. Being nutritious, they are easily contaminated by foodborne pathogens, which causes serious damage to human health. Therefore, the prevention and control of foodborne pathogen contamination in meat and meat products is of great importance for food safety. In order to deeply understand the relationship between foodborne pathogens and epithelial cells in the whole infection process, it is a prerequisite to establish an effective intestinal evaluation model. Accordingly, this paper summarizes the infection status of common foodborne pathogens in meat and meat products, and discusses the in vivo and in vitro models currently used to assess the infection of foodborne pathogens. Among them, intestinal organoids, a new model to evaluate the infection mechanism of foodborne pathogens, have great potential in the research of the pathogenic mechanism, cell and tissue tropism. Therefore, this paper focuses on the current status of the application of intestinal organoid models in research on the infection mechanism of foodborne pathogens, and discusses the characteristics and problems of the current intestinal organoid models as well as future development directions.
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