Alzheimer's disease (AD) is marked by severe neurodegeneration and cognitive decline, presenting significant challenges for its prevention and treatment. Traditional hypotheses have focused on amyloid-beta plaques and Tau pathology, but recent findings point to a significant role for microglial dysfunction and mitochondrial impairment. Given these challenges, there is a pressing need for deeper research into the mechanisms underlying AD.

A team from the Laboratory of Aging Neuroscience and Neuropharmacology at China Pharmaceutical University and Chungnam National University published a review in January 2024, in the journal Aging Research. This research explores the interaction between microglial dysfunction and mitochondrial impairment in AD, offering new insights into the disease's progression.

The study reveals that microglia, the primary immune cells in the central nervous system, play a crucial role in AD progression. Under normal conditions, microglia maintain neuronal homeostasis and clear metabolic byproducts. However, in AD, mitochondrial dysfunction leads to abnormal microglial activity, resulting in neuroinflammation and neuronal loss. The researchers emphasize the importance of maintaining mitochondrial homeostasis for proper microglial function. They highlight how metabolic disturbances and energy dysregulation in microglia significantly contribute to AD development. Additionally, the study explores mechanisms underlying microglial activation and its effects on neuronal health, focusing on the interplay between inflammatory pathways and mitochondrial dynamics. These findings suggest that targeting microglial mitochondria could be a promising therapeutic strategy to mitigate AD progression, providing a new direction for developing treatments that address the disease's root causes.

Dr. Jian Sima, lead author of the study, states, "Our findings highlight the intricate relationship between microglial activity and mitochondrial function in AD. By understanding this connection, we can develop targeted therapies that address the root causes of microglial dysfunction, potentially slowing or even halting disease progression."

This research underscores the potential of targeting microglial mitochondria as a therapeutic strategy for AD. By restoring mitochondrial function in microglia, it may be possible to reduce neuroinflammation and neuronal loss, thereby improving cognitive function in AD patients. These findings pave the way for developing novel treatments that could significantly impact how we approach Alzheimer's therapy in the future.

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The interaction between microglial dysfunction and mitochondrial impairment in Alzheimer’s disease

About Aging Research

Aging Research is a peer-reviewed, Open Access publication sponsored by Jinan University and published by Tsinghua University Press. It publishes original research in all areas of aging, longevity, aging related diseases and health issues, specific accepting the unusual significance or broad conceptual or technical advances results, the innovative phenotypic reporting without relevant mechanisms, innovative clinical case reports and studies with negative results. Aging Research aims to foster interactions among different areas of this diverse field of research and to promote new and exciting ideas within and beyond the research community, to enable synergy and maximize scientific and societal impact.