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Original Article | Open Access

Characterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons

Fada Guan1Huixiao Chen1Emily Draeger1Yuting Li2Resat Aydin3Christopher J. Tien1Zhe Chen1( )
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas, USA
Ashland Specialty Ingredients G.P., Bridgewater, New Jersey, USA
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Abstract

Objective

A newly developed GafchromicTM EBT4 film model was released recently. According to the vendor-stated specifications, this new model maintains major features of its more recent predecessor, EBT3, but has a great improvement in the signal-to-noise ratio (SNR). The purpose of this study was to fully characterize the EBT4 model by testing its dose response dependence on beam energy using clinical photon and electron beams and validating its improvement in SNR.

Methods

In the beam energy dependence experiments, 6 MV and 15 MV photon beams, 6 MeV, 12 MeV and 20 MeV electron beams, 120 kVp and two 250 kVp x-ray beams (with different half-layer values) were selected, representing different clinical beam energies and radiation types. In the noise and SNR analyses, only the 6 MV photon beam was selected as the representative to compare between EBT4 and EBT3 models.

Results

The energy dependence test results showed that there was a slight difference (<2% at most dose levels) in the dose response among the clinical MV photons and MeV electrons. However, a large deviation (>10%) in the dose response was found for the 120 kVp x-ray beam. For the two 250 kVp x-ray beams, the difference in the dose response was moderate (<5%), but not negligible. The noise and SNR results showed a reduced noise and strengthened SNR in EBT4.

Conclusion

We conclude that the EBT4 film has a minimal energy dependence for MV photon and MeV electron beams but has a notable energy dependence for kilovoltage x-ray beams, and the vendor-stated features of the reduced noise and improved SNR in EBT4 are validated.

References

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Niroomand-Rad A, Chiu-Tsao ST, Grams MP et al. Report of AAPM task group 235 radiochromic film dosimetry: an update to TG-55. Med Phys. 2020;47:5986-6025.

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Chan MF, Park J, Aydin R, Lim SB, Energy dependence of the Gafchromic EBT4 film: Dose-response curves for 70 kV, 6 MV, 6 MV FFF, 10 MV FFF, and 15 MV x-ray beams. Med Phys. 2023;50(6):3738-3745.

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Almond PR, Biggs PJ, Coursey BM, et al. AAPM's TG-51 protocol for clinical reference dosimetry of high-energy photon and electron beams. Med Phys. 1999;26:1847-1870.

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Perles L, Mirkovic D, Anand A, Titt U, Mohan R. LET dependence of the response of EBT2 films in proton dosimetry modeled as a bimolecular chemical reaction. Phys Med Biol. 2013;58:8477.

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Guan F, Wang X, Yang M, et al. Dosimetric response of GafchromicTM EBT-XD film to therapeutic protons. Precis Radiat Oncol. 2023;7:15-26.

Precision Radiation Oncology
Pages 84-91
Cite this article:
Guan F, Chen H, Draeger E, et al. Characterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons. Precision Radiation Oncology, 2023, 7(2): 84-91. https://doi.org/10.1002/pro6.1204

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Received: 06 April 2023
Revised: 12 May 2023
Accepted: 15 May 2023
Published: 25 June 2023
© 2023 The Authors.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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