Sort:
Open Access Editorial Issue
Editorial: Innovations, advances, and challenges in precision radiation oncology physics
Precision Radiation Oncology 2023, 7 (4): 222-224
Published: 29 December 2023
Abstract Collect
Open Access Original Article Issue
Characterization of GafchromicTM EBT4 film with clinical kV/MV photons and MeV electrons
Precision Radiation Oncology 2023, 7 (2): 84-91
Published: 25 June 2023
Abstract Collect
Objective

A newly developed GafchromicTM EBT4 film model was released recently. According to the vendor-stated specifications, this new model maintains major features of its more recent predecessor, EBT3, but has a great improvement in the signal-to-noise ratio (SNR). The purpose of this study was to fully characterize the EBT4 model by testing its dose response dependence on beam energy using clinical photon and electron beams and validating its improvement in SNR.

Methods

In the beam energy dependence experiments, 6 MV and 15 MV photon beams, 6 MeV, 12 MeV and 20 MeV electron beams, 120 kVp and two 250 kVp x-ray beams (with different half-layer values) were selected, representing different clinical beam energies and radiation types. In the noise and SNR analyses, only the 6 MV photon beam was selected as the representative to compare between EBT4 and EBT3 models.

Results

The energy dependence test results showed that there was a slight difference (<2% at most dose levels) in the dose response among the clinical MV photons and MeV electrons. However, a large deviation (>10%) in the dose response was found for the 120 kVp x-ray beam. For the two 250 kVp x-ray beams, the difference in the dose response was moderate (<5%), but not negligible. The noise and SNR results showed a reduced noise and strengthened SNR in EBT4.

Conclusion

We conclude that the EBT4 film has a minimal energy dependence for MV photon and MeV electron beams but has a notable energy dependence for kilovoltage x-ray beams, and the vendor-stated features of the reduced noise and improved SNR in EBT4 are validated.

Open Access Original Article Issue
Dosimetric response of Gafchromic™ EBT-XD film to therapeutic protons
Precision Radiation Oncology 2023, 7 (1): 15-26
Published: 02 March 2023
Abstract Collect

The EBT-XD model of Gafchromic™ films has a broader optimal dynamic dose range, up to 40 Gy, compared with its predecessor models. This characteristic has made EBT-XD films suitable for high-dose applications, such as stereotactic body radiotherapy and stereotactic radiosurgery, as well as ultra-high dose rate FLASH radiotherapy. The purpose of the current study was to characterize the dependence of EBT-XD film response on linear energy transfer (LET) and dose rate of therapeutic protons from a synchrotron. A clinical spot-scanning proton beam was used to study LET dependence at three dose-averaged LET values of 1.0 keV/μm, 3.6 keV/μm, and 7.6 keV/μm. A research proton beamline was used to study dose rate dependence at 150 Gy/s in the FLASH mode and 0.3 Gy/s in the non-FLASH mode. Film response data from dose-averaged LET values of 0.9 keV/μm and 9.0 keV/μm of the proton FLASH beam were also compared. Film response data from a clinical 6-MV photon beam were used as a reference. Both the gray value method and optical density (OD) method were used in film calibration. Calibration results using a specific OD calculation method and a generic OD calculation method were compared. The four-parameter NIH Rodbard function and three-parameter rational function were compared in fitting the calibration curves. Experimental results showed that the response of EBT-XD film is proton LET dependent, but independent of dose rate. Goodness-of-fit analysis showed that using the NIH Rodbard function is superior for both protons and photons. Using the "specific OD + NIH Rodbard function" method for EBT-XD film calibration is recommended.

Total 3