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Research Article

Engineering CeO2/CuO heterostructure anchored on upconversion nanoparticles with boosting ROS generation-primed apoptosis-ferroptosis for cancer dynamic therapy

Xuan Gao1,2, Jing Feng1,2( ), Kehong Lv1,2, Yifei Zhou1,2, Ruohao Zhang1,2, Shuyan Song1,2, Hongjie Zhang1,2,3 ( ), Daguang Wang4( )
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China
Department of Chemistry, Tsinghua University, Beijing 100084, China
Gastric and Intestinal Department, General Surgery Center, First Hospital of Jilin University, Changchun 130021, China
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Graphical Abstract

An intelligent nanocomposite with designed CeO2/CuO heterostructure anchored on upconversion nanoparticles and cancer cell membrane modification exhibits great cytotoxicity toward cancer cells to trigger combinative apoptosis and ferroptosis via synergistic synergistic photodynamic therapy (PDT)/chemodynamic therapy (CDT).

Abstract

Highly toxic reactive oxygen species (ROS) induced apoptosis and ferroptosis have been considered as significant cell death pathways for cancer therapy. However, insufficient amount of intracellular ROS extremely restricts the therapeutic effect. Toward this, we report a rationally designed nanocomposite (mUCC) with enhanced ROS generation ability, inducing the combination of apoptosis and ferroptosis through synergistic photodynamic therapy (PDT) and chemodynamic therapy (CDT). Under 808 nm near-infrared (NIR) light irradiation, photocatalytic reaction is triggered starting from the separation of electron–hole pairs on the surface of heterojunction (CeO2/CuO), realizing improved ROS production. Simultaneously, mUCC served as Fenton-like agent exhibits considerable ability to generate highly toxic ·OH under tumor microenvironment (TME). The boosted accumulation of ROS disrupts the redox balance within tumor cells and results in the integration of apoptosis and ferroptosis. In addition, mUCC shows satisfactory tumor targeting property benefiting from the cancer cell membrane functionalization under the guidance of magnetic resonance imaging (MRI) and NIR fluorescence imaging. The intelligent mUCC with good biocompatibility and excellent antitumor response achieves efficient tumor elimination under synergistic PDT and CDT. This work offers an elective approach for further development of ROS-based therapeutic nanoplatform in cancer therapy.

Keywords

upconversion nanoparticlesheterojunctionreactive oxygen speciesapoptosis-ferroptosissynergistic dynamic therapy

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Nano Research
Volume 16 Issue 4,
April 2023
Pages 5322-5334
DOI: 10.1007/s12274-022-5223-4
Cite this article:
Gao X, Feng J, Lv K, et al. Engineering CeO2/CuO heterostructure anchored on upconversion nanoparticles with boosting ROS generation-primed apoptosis-ferroptosis for cancer dynamic therapy. Nano Research, 2023, 16(4): 5322-5334. https://doi.org/10.1007/s12274-022-5223-4
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Received: 28 September 2022
Revised: 18 October 2022
Accepted: 19 October 2022
Published: 10 January 2023
© Tsinghua University Press 2022
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