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Topical Review | Open Access

Engineering vascularized organotypic tissues via module assembly

Zhenzhen Zhou1,2,3Changru Liu1,2,3Yuting Guo1,2,3Yuan Pang1,2,3( )Wei Sun1,2,3,4
Biomanufacturing Center, Department of Mechanical Engineering, Tsinghua University, Haidian District, Beijing 100084, People’s Republic of China
Biomanufacturing and Rapid Forming Technology Key Laboratory of Beijing, Beijing 100084, People’s Republic of China
Key Laboratory for Advanced Materials Processing Technology, Ministry of Education, Beijing 100084, People’s Republic of China
Department of Mechanical Engineering, Drexel University, Philadelphia, PA 19104, United States of America
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Abstract

Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular maturation make vascularized organotypic tissue construction difficult, greatly limiting its use in tissue engineering and regenerative medicine. To address these limitations, recent studies have adopted pre-vascularized microtissue assembly for the rapid generation of functional tissue analogs with dense vascular networks and high cell density. In this article, we summarize the development of module assembly-based vascularized organotypic tissue construction and its application in tissue repair and regeneration, organ-scale tissue biomanufacturing, as well as advanced tissue modeling.

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International Journal of Extreme Manufacturing
Cite this article:
Zhou Z, Liu C, Guo Y, et al. Engineering vascularized organotypic tissues via module assembly. International Journal of Extreme Manufacturing, 2024, 6(1): 012006. https://doi.org/10.1088/2631-7990/acfcf2

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Received: 05 June 2023
Revised: 27 July 2023
Accepted: 24 September 2023
Published: 11 October 2023
© 2023 The Author(s).

Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.

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