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An in-depth overview of the molecular mechanisms governing ovarian aging and the corresponding preventative and therapeutic strategies

Yanyan Fu1, Yingshi Cao1, Yifei Yan2, Sini Huang1, Shumin Li3, Yanhao Huang3, Zhixian Wang3, Lijuan Gao3(), Chanchan Xiao3,4,5()
Guangzhou Baiyun District Maternal and Child Health Hospital, Guangzhou 510632, China
School of Medicine, Guangdong Medical University, Zhanjiang 524023, China
Department of Microbiology and Immunology, Institute of Geriatric Immunology, School of Medicine, Jinan University, Guangzhou 510632, China
The Sixth Affiliated Hospital, Jinan University, Guangzhou 510632, China
Zhuhai Institute of Jinan University, Jinan University, Zhuhai 519070, China
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Abstract

Ovarian aging is a progressive and dynamic process closely related to age, in which ovarian function gradually declines until exhaustion; this process is influenced by a combination of factors, including genetics, lifestyle, environment, psychosocial factors, and iatrogenic factors. It is closely related to the quantity and quality of follicles in the ovaries and is characterized by changes in female hormone levels and fertility. Therefore, understanding the factors influencing ovarian aging, its molecular mechanisms, and strategies for prevention and intervention is of significant importance for comprehending and addressing the challenges posed by ovarian aging.

Keywords

ovarian agingmolecular mechanismspreventative and therapeutic strategies

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Aging Research
Volume 2 Issue 1,
March 2024
Article number: 9340023
DOI: 10.26599/AGR.2024.9340023
Cite this article:
Fu Y, Cao Y, Yan Y, et al. An in-depth overview of the molecular mechanisms governing ovarian aging and the corresponding preventative and therapeutic strategies. Aging Research, 2024, 2(1): 9340023. https://doi.org/10.26599/AGR.2024.9340023
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Medications for retarding ovarian aging and preserving ovarian function

CategoryDrugFunctionRefs.
Plant extractProanthocyanidinsAntioxidation[35]
CurcuminFoster follicle formation and hormone synthesis[36]
HesperidinFoster the growth and maturation of mouse follicles[37]
QuercetinEnhance the vitality of granulosa cells to improve subsequent fetal development[38]
CompoundMetforminImproving age-related ovarian fibrosis[39]
ResveratrolImprove the quantity and quality of oocytes[40]
RapamycinIncrease the number of follicles[41]
MelatoninProtecting ovarian function damage in mice caused by cisplatin by reducing oxidative stress[42]
Chinese medicineAmerican ginseng (ginsenoside)Delaying the onset of premature ovarian failure in mice induced by D-gal[43]
EpimediumPromote the repair of DNA damage to effectively mitigate ovarian injury[44]