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Review Article | Open Access

Anhedonia and its intervention in depressive adults: New developments based on Research Domain Criteria (RDoC) in mental illnesses

 Faculty of Psychology, Southwest University, Chongqing 400715, China
 The Affect Cognition and Regulation Laboratory, Institute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu 610066, China
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Abstract

Anhedonia, as one of the core symptoms of depression, is of great significance for the diagnosis and treatment of depression. Traditionally, anhedonia has been referred to as "loss of pleasure", while the recent research emphasizes that anhedonia is a complex and multidimensional construct based on reward processing impairment. Exploring different manifestations of anhedonia and developing the corresponding interventions have become indispensable in the current research of depression. Based on the positive valence system of the Research Domain Criteria (RDoC), this paper firstly demonstrates that the anhedonia of depressive adults are mainly characterized by the impairments in anticipatory pleasure, incentive motivation/effort, and reward learning based on subjective rating, behavioral, and neurophysiological evidences, while the existing evidences for the consummatory anhedonia of depression are inconsistent. Additionally, we introduce the vulnerability–stress model, as the mainstream theory of anhedonia in depression, and also emphasize the role of dopamine system abnormalities and altered brain structures or functional networks underpinning reward processing in the pathogenesis of anhedonia. Furthermore, to reinstate reward processing in depressed adults, various effective interventions for anhedonia have been developed, including direct psychosocial interventions, indirect working memory training, and real-time neurofeedback training with functional magnetic resonance imaging (fMRI). Future research needs to deeply investigate the role of stress and gene polymorphisms in the etiology and mechanism of anhedonia in depression. Besides, more attention should be paid to social anhedonia in depressed individuals. And we also emphasize the need to further promote translational studies on the clinical interventions of anhedonia.

Keywords

anhedoniadepressionadultsreward processingintervention

References

[1]
World Health Organization. Depression. 2018. Available at: http://www.who.int/news-room/fact-sheets/detail/depression (accessed 2020).
[2]
Association, A. P. Diagnostic and Statistical Manual of Mental Disorders, 4th edn. Arlington: American Psychiatric Association, 2000.
[3]
Hasler, G., Drevets, W. C., Manji, H. K., Charney, D. S. Discovering endophenotypes for major depression. Neuropsychopharmacology, 2004, 29(10): 1765–1781.
Crossref Google Scholar
[4]
Bonanni, Gualtieri, Lester, Falcone, Nardella, Fiorillo, Pompili. Can anhedonia be considered a suicide risk factor? A review of the literature. Medicina, 2019, 55(8): 458.
Crossref Google Scholar
[5]
Fawcett, J., Scheftner, W. A., Fogg, L., Clark, D. C., Young, M. A., Hedeker, D., Gibbons, R. D. Time-related predictors of suicide in major affective disorder. American Journal of Psychiatry, 1990, 147(9): 1189–1194.
Crossref Google Scholar
[6]
Klonsky, E. D. What is emptiness? clarifying the 7th criterion for borderline personality disorder. Journal of Personality Disorders, 2008, 22(4): 418–426.
Crossref Google Scholar
[7]
Morris, B. H., Bylsma, L. M., Rottenberg, J. Does emotion predict the course of major depressive disorder? A review of prospective studies. British Journal of Clinical Psychology, 2009, 48(3): 255–273.
Crossref Google Scholar
[8]
Winer, E. S., Nadorff, M. R., Ellis, T. E., Allen, J. G., Herrera, S., Salem, T. Anhedonia predicts suicidal ideation in a large psychiatric inpatient sample. Psychiatry Research, 2014, 218(1–2): 124–128.
Crossref Google Scholar
[9]
McMakin, D. L., Olino, T. M., Porta, G., Dietz, L. J., Emslie, G., Clarke, G., Wagner, K. D., Asarnow, J. R., Ryan, N. D., Birmaher, B. et al. Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment–resistant depression. Journal of the American Academy of Child & Adolescent Psychiatry, 2012, 51(4): 404–411.
Crossref Google Scholar
[10]
Spijker, J., Bijl, R. V., de Graaf, R., Nolen, W. A. Determinants of poor 1-year outcome of DSM-III-R major depression in the general population: Results of the Netherlands Mental Health Survey and Incidence Study (NEMESIS). Acta Psychiatrica Scandinavica, 2001, 103(2): 122–130.
Crossref Google Scholar
[11]
Uher, R., Perlis, R. H., Henigsberg, N., Zobel, A., Rietschel, M., Mors, O., Hauser, J., Dernovsek, M. Z., Souery, D., Bajs, M. et al. Depression symptom dimensions as predictors of antidepressant treatment outcome: Replicable evidence for interest-activity symptoms. Psychological Medicine, 2012, 42(5): 967–980.
Crossref Google Scholar
[12]
Berridge, K. C., Robinson, T. E. Parsing reward. Trends in Neurosciences, 2003, 26(9): 507–513.
Crossref Google Scholar
[13]
Chen, Y. M., Xu, J., Zhou, L., Zheng, Y. The time course of incentive processing in anticipatory and consummatory anhedonia. Journal of Affective Disorders, 2018, 238: 442–450.
Crossref Google Scholar
[14]
Gard, D. E., Gard, M. G., Kring, A. M., John, O. P. Anticipatory and consummatory components of the experience of pleasure: A scale development study. Journal of Research in Personality, 2006, 40(6): 1086–1102.
Crossref Google Scholar
[15]
Klein, D. Depression and anhedonia. In: Clark, D. C., Fawcett J. (eds.), Anhedonia and affect deficit states. New York: PMA Publishing, 1984: 1–14.
[16]
Treadway, M. T., Zald, D. H. Reconsidering anhedonia in depression: Lessons from translational neuroscience. Neuroscience & Biobehavioral Reviews, 2011, 35(3): 537–555.
Crossref Google Scholar
[17]
Craske, M. G., Meuret, A. E., Ritz, T., Treanor, M., Dour, H. J. Treatment for anhedonia: A neuroscience driven approach. Depression and Anxiety, 2016, 33(10): 927–938.
Crossref Google Scholar
[18]
Rømer Thomsen, K., Whybrow, P. C., Kringelbach, M. L. Reconceptualizing anhedonia: Novel perspectives on balancing the pleasure networks in the human brain. Frontiers in Behavioral Neuroscience, 2015, 9: 49.
Crossref Google Scholar
[19]
Sanislow, C. A., Pine, D. S., Quinn, K. J., Kozak, M. J., Garvey, M. A., Heinssen, R. K., Wang, P. S. E., Cuthbert, B. N. Developing constructs for psychopathology research: Research domain criteria. Journal of Abnormal Psychology, 2010, 119(4): 631–639.
Crossref Google Scholar
[20]
Gooding, D. C., Pflum, M. J. The Anticipatory and consummatory interpersonal pleasure scale (ACIPS). Madison: University of Wisconsin, 2011.
[21]
Gooding, D. C., Pflum, M. J. The assessment of interpersonal pleasure: Introduction of the Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS) and preliminary findings. Psychiatry Research, 2014, 215(1): 237–243.
Crossref Google Scholar
[22]
Knutson, B., Westdorp, A., Kaiser, E., Hommer, D. FMRI visualization of brain activity during a monetary incentive delay task. NeuroImage, 2000, 12(1): 20–27.
Crossref Google Scholar
[23]
Smoski, M. J., Rittenberg, A., Dichter, G. S. Major depressive disorder is characterized by greater reward network activation to monetary than pleasant image rewards. Psychiatry Research, 2011, 194(3): 263–270.
Crossref Google Scholar
[24]
Lutz, K., Widmer, M. What can the monetary incentive delay task tell us about the neural processing of reward and punishment? Neuroscience and Neuroeconomics, 2014: 33.
Crossref Google Scholar
[25]
Forbes, E. E., Hariri, A. R., Martin, S. L., Silk, J. S., Moyles, D. L., Fisher, P. M., Brown, S. M., Ryan, N. D., Birmaher, B., Axelson, D. A. et al. Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder. American Journal of Psychiatry, 2009, 166(1): 64–73.
Crossref Google Scholar
[26]
Liu, W. H., Chan, R. C. K., Wang, L. Z., Huang, J., Cheung, E. F. C., Gong, Q. Y., Gollan, J. K. Deficits in sustaining reward responses in subsyndromal and syndromal major depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2011, 35(4): 1045–1052.
Crossref Google Scholar
[27]
Sherdell, L., Waugh, C. E., Gotlib, I. H. Anticipatory pleasure predicts motivation for reward in major depression. Journal of Abnormal Psychology, 2012, 121(1): 51–60.
Crossref Google Scholar
[28]
Xiong, Z., Zheng, S., Xie, W., Zhu, L., Meng, S., Wang, T. Correlation study of anhedonia and incentive motivation impairment in depression patients. Journal of Clinical Psychosomatic Disease, 2013, 19(6): 528–531.
Google Scholar
[29]
Yang, X. H., Huang, J., Zhu, C. Y., Wang, Y. F., Cheung, E. F. C., Chan, R. C. K., Xie, G. R. Motivational deficits in effort-based decision making in individuals with subsyndromal depression, first-episode and remitted depression patients. Psychiatry Research, 2014, 220(3): 874–882.
Crossref Google Scholar
[30]
McFarland, B. R., Klein, D. N. Emotional reactivity in depression: Diminished responsiveness to anticipated reward but not to anticipated punishment or to nonreward or avoidance. Depression and Anxiety, 2009, 26(2): 117–122.
Crossref Google Scholar
[31]
Pizzagalli, D. A., Holmes, A. J., Dillon, D. G., Goetz, E. L., Birk, J. L., Bogdan, R., Dougherty, D. D., Iosifescu, D. V., Rauch, S. L., Fava, M. Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder. American Journal of Psychiatry, 2009, 166(6): 702–710.
Crossref Google Scholar
[32]
Knutson, B., Bhanji, J. P., Cooney, R. E., Atlas, L. Y., Gotlib, I. H. Neural responses to monetary incentives in major depression. Biological Psychiatry, 2008, 63(7): 686–692.
Crossref Google Scholar
[33]
Ubl, B., Kuehner, C., Kirsch, P., Ruttorf, M., Diener, C., Flor, H. Altered neural reward and loss processing and prediction error signalling in depression. Social Cognitive and Affective Neuroscience, 2015, 10(8): 1102–1112.
Crossref Google Scholar
[34]
Jarbo, K., Verstynen, T. D. Converging structural and functional connectivity of orbitofrontal, dorsolateral prefrontal, and posterior parietal cortex in the human striatum. Journal of Neuroscience, 2015, 35(9): 3865–3878.
Crossref Google Scholar
[35]
Stoy, M., Schlagenhauf, F., Sterzer, P., Bermpohl, F., Hägele, C., Suchotzki, K., Schmack, K., Wrase, J., Ricken, R., Knutson, B., et al. Hyporeactivity of ventral striatum towards incentive stimuli in unmedicated depressed patients normalizes after treatment with escitalopram. Journal of Psychopharmacology, 2012, 26(5): 677–688.
Crossref Google Scholar
[36]
Smoski, M. J., Felder, J., Bizzell, J., Green, S. R., Ernst, M., Lynch, T. R., Dichter, G. S. fMRI of alterations in reward selection, anticipation, and feedback in major depressive disorder. Journal of Affective Disorders, 2009, 118(1–3): 69–78.
Crossref Google Scholar
[37]
Gorka, S. M., Huggins, A. A., Fitzgerald, D. A., Nelson, B. D., Phan, K. L., Shankman, S. A. Neural response to reward anticipation in those with depression with and without panic disorder. Journal of Affective Disorders, 2014, 164: 50–56.
Crossref Google Scholar
[38]
Zhang, W. N., Chang, S. H., Guo, L. Y., Zhang, K. L., Wang, J. The neural correlates of reward-related processing in major depressive disorder: A meta-analysis of functional magnetic resonance imaging studies. Journal of Affective Disorders, 2013, 151(2): 531–539.
Crossref Google Scholar
[39]
Pizzagalli, D. A. Depression, stress, and anhedonia: Toward a synthesis and integrated model. Annual Review of Clinical Psychology, 2014, 10(1): 393–423.
Crossref Google Scholar
[40]
Balleine, B. W., Delgado, M. R., Hikosaka, O. The role of the dorsal striatum in reward and decision-making. Journal of Neuroscience, 2007, 27(31): 8161–8165.
Crossref Google Scholar
[41]
Haber, S. N., Knutson, B. The reward circuit: Linking primate anatomy and human imaging. Neuropsychopharmacology, 2010, 35(1): 4–26.
Crossref Google Scholar
[42]
Wallis, J. D., Kennerley, S. W. Heterogeneous reward signals in prefrontal cortex. Current Opinion in Neurobiology, 2010, 20(2): 191–198.
Crossref Google Scholar
[43]
Zhang, B., Lin, P., Shi, H. Q., Öngür, D., Auerbach, R. P., Wang, X. S., Yao, S. Q., Wang, X. Mapping anhedonia-specific dysfunction in a transdiagnostic approach: An ALE meta-analysis. Brain Imaging and Behavior, 2016, 10(3): 920–939.
Crossref Google Scholar
[44]
Hallford, D. J., Barry, T. J., Austin, D. W., Raes, F., Takano, K., Klein, B. Impairments in episodic future thinking for positive events and anticipatory pleasure in major depression. Journal of Affective Disorders, 2020, 260: 536–543.
Crossref Google Scholar
[45]
Franken, I. H. A., Rassin, E., Muris, P. The assessment of anhedonia in clinical and non-clinical populations: Further validation of the Snaith–Hamilton Pleasure Scale (SHAPS). Journal of Affective Disorders, 2007, 99(1–3): 83–89.
Crossref Google Scholar
[46]
Snaith, R. P., Hamilton, M., Morley, S., Humayan, A., Hargreaves, D., Trigwell, P. A scale for the assessment of hedonic tone the snaith–Hamilton pleasure scale. British Journal of Psychiatry, 1995, 167(1): 99–103.
Crossref Google Scholar
[47]
Martinotti, G., Sepede, G., Gambi, F., di Iorio, G., de Berardis, D., di Nicola, M., Onofrj, M., Janiri, L., di Giannantonio, M. Agomelatine versus venlafaxine XR in the treatment of anhedonia in major depressive disorder. Journal of Clinical Psychopharmacology, 2012, 32(4): 487–491.
Crossref Google Scholar
[48]
Fawcett, J., Clark, D. C., Scheftner, W. A., Gibbons, R. D. Assessing anhedonia in psychiatric patients: The Pleasure Scale. Archives of General Psychiatry, 1983, 40(1), 79–84.
Crossref Google Scholar
[49]
Leventhal, A. M., Chasson, G. S., Tapia, E., Miller, E. K., Pettit, J. W. Measuring hedonic capacity in depression: A psychometric analysis of three anhedonia scales. Journal of Clinical Psychology, 2006, 62(12): 1545–1558.
Crossref Google Scholar
[50]
Chapman, L. J., Chapman, J. P., Raulin, M. L. Scales for physical and social anhedonia. Journal of Abnormal Psychology, 1976, 85(4): 374–382.
Crossref Google Scholar
[51]
Rizvi, S. J., Quilty, L. C., Sproule, B. A., Cyriac, A., Michael Bagby, R., Kennedy, S. H. Development and validation of the Dimensional Anhedonia Rating Scale (DARS) in a community sample and individuals with major depression. Psychiatry Research, 2015, 229(1–2): 109–119.
Crossref Google Scholar
[52]
Forbes, E. E., Brown, S. M., Kimak, M., Ferrell, R. E., Manuck, S. B., Hariri, A. R. Genetic variation in components of dopamine neurotransmission impacts ventral striatal reactivity associated with impulsivity. Molecular Psychiatry, 2009, 14(1): 60–70.
Crossref Google Scholar
[53]
Rottenberg, J., Kasch, K. L., Gross, J. J., Gotlib, I. H. Sadness and amusement reactivity differentially predict concurrent and prospective functioning in major depressive disorder. Emotion (Washington, D.C.), 2002, 2(2): 135–146.
Crossref Google Scholar
[54]
Stuhrmann, A., Dohm, K., Kugel, H., Zwanzger, P., Redlich, R., Grotegerd, D., Rauch, A., Arolt, V., Heindel, W., Suslow, T., et al. Mood-congruent amygdala responses to subliminally presented facial expressions in major depression: Associations with anhedonia. Journal of Psychiatry & Neuroscience, 2013, 38(4): 249–258.
Crossref Google Scholar
[55]
Dichter, G. S., Smoski, M. J., Kampov-Polevoy, A. B., Gallop, R., Garbutt, J. C. Unipolar depression does not moderate responses to the Sweet Taste Test. Depression and Anxiety, 2010, 27(9): 859–863.
Crossref Google Scholar
[56]
McCabe, C., Cowen, P. J., Harmer, C. J. Neural representation of reward in recovered depressed patients. Psychopharmacology, 2009, 205(4): 667–677.
Crossref Google Scholar
[57]
Duffy, V. B., Bartoshuk, L. M. Food acceptance and genetic variation in taste. Journal of the American Dietetic Association, 2000, 100(6): 647–655.
Crossref Google Scholar
[58]
Berenbaum, H., Oltmanns, T. F. Emotional experience and expression in schizophrenia and depression. Journal of Abnormal Psychology, 1992, 101(1): 37–44.
Crossref Google Scholar
[59]
Kaviani, H., Gray, J. A., Checkley, S. A., Raven, P. W., Wilson, G. D., Kumari, V. Affective modulation of the startle response in depression: Influence of the severity of depression, anhedonia, and anxiety. Journal of Affective Disorders, 2004, 83(1): 21–31.
Crossref Google Scholar
[60]
Sloan, D. M., Strauss, M. E., Wisner, K. L. Diminished response to pleasant stimuli by depressed women. Journal of Abnormal Psychology, 2001, 110(3): 488–493.
Crossref Google Scholar
[61]
Berlin, I., Givry-Steiner, L., Lecrubier, Y., Puech, A. J. Measures of anhedonia and hedonic responses to sucrose in depressive and schizophrenic patients in comparison with healthy subjects. European Psychiatry, 1998, 13(6): 303–309.
Crossref Google Scholar
[62]
Dichter, G. S., Tomarken, A. J., Shelton, R. C., Sutton, S. K. Early- and late-onset startle modulation in unipolar depression. Psychophysiology, 2004, 41(3): 433–440.
Crossref Google Scholar
[63]
Tsai, J. L., Pole, N., Levenson, R. W., Muñoz, R. F. The effects of depression on the emotional responses of Spanish-speaking Latinas. Cultural Diversity and Ethnic Minority Psychology, 2003, 9(1): 49–63.
Crossref Google Scholar
[64]
Forbes, E. E., Miller, A., Cohn, J. F., Fox, N. A., Kovacs, M. Affect-modulated startle in adults with childhood-onset depression: Relations to bipolar course and number of lifetime depressive episodes. Psychiatry Research, 2005, 134(1): 11–25.
Crossref Google Scholar
[65]
Epstein, J., Pan, H., Kocsis, J. H., Yang, Y. H., Butler, T., Chusid, J., Hochberg, H., Murrough, J., Strohmayer, E., Stern, E., et al. Lack of ventral striatal response to positive stimuli in depressed versus normal subjects. American Journal of Psychiatry, 2006, 163(10): 1784–1790.
Crossref Google Scholar
[66]
Fu, C. H. Y., Williams, S. C. R., Brammer, M. J., Suckling, J., Kim, J., Cleare, A. J., Walsh, N. D., Mitterschiffthaler, M. T., Andrew, C. M., Pich, E. M. et al. Neural responses to happy facial expressions in major depression following antidepressant treatment. American Journal of Psychiatry, 2007, 164(4): 599–607.
Crossref Google Scholar
[67]
Surguladze, S., Brammer, M. J., Keedwell, P., Giampietro, V., Young, A. W., Travis, M. J., Williams, S. C. R., Phillips, M. L. A differential pattern of neural response toward sad versus happy facial expressions in major depressive disorder. Biological Psychiatry, 2005, 57(3): 201–209.
Crossref Google Scholar
[68]
Canli, T., Sivers, H., Thomason, M. E., Whitfield-Gabrieli, S., Gabrieli, J. D. E., Gotlib, I. H. Brain activation to emotional words in depressed vs healthy subjects. Neuroreport, 2004, 15(17): 2585–2588.
Crossref Google Scholar
[69]
Gotlib, I. H., Sivers, H., Gabrieli, J. D. E., Whitfield-Gabrieli, S., Goldin, P., Minor, K. L., Canli, T. Subgenual anterior cingulate activation to valenced emotional stimuli in major depression. Neuroreport, 2005, 16(16): 1731–1734.
Crossref Google Scholar
[70]
Keedwell, P. A., Andrew, C., Williams, S. C. R., Brammer, M. J., Phillips, M. L. A double dissociation of ventromedial prefrontal cortical responses to sad and happy stimuli in depressed and healthy individuals. Biological Psychiatry, 2005, 58(6): 495–503.
Crossref Google Scholar
[71]
Yuan, J. W., Kring, A. M. Dysphoria and the prediction and experience of emotion. Cognition and Emotion, 2009, 23(6): 1221–1232.
Crossref Google Scholar
[72]
Pizzagalli, D. A., Jahn, A. L., O'Shea, J. P. Toward an objective characterization of an anhedonic phenotype: A signal-detection approach. Biological Psychiatry, 2005, 57(4): 319–327.
Crossref Google Scholar
[73]
Kumar, P., Waiter, G., Ahearn, T., Milders, M., Reid, I., Steele, J. D. Abnormal temporal difference reward-learning signals in major depression. Brain, 2008, 131(8): 2084–2093.
Crossref Google Scholar
[74]
Gradin, V. B., Kumar, P., Waiter, G., Ahearn, T., Stickle, C., Milders, M., Reid, I., Hall, J., Steele, J. D. Expected value and prediction error abnormalities in depression and schizophrenia. Brain, 2011, 134(6): 1751–1764.
Crossref Google Scholar
[75]
Dombrovski, A. Y., Clark, L., Siegle, G. J., Butters, M. A., Ichikawa, N., Sahakian, B. J., Szanto, K. Reward/punishment reversal learning in older suicide attempters. American Journal of Psychiatry, 2010, 167(6): 699–707.
Crossref Google Scholar
[76]
Pizzagalli, D. A., Iosifescu, D., Hallett, L. A., Ratner, K. G., Fava, M. Reduced hedonic capacity in major depressive disorder: Evidence from a probabilistic reward task. Journal of Psychiatric Research, 2008, 43(1): 76–87.
Crossref Google Scholar
[77]
Chen, C., Takahashi, T., Nakagawa, S., Inoue, T., Kusumi, I. Reinforcement learning in depression: A review of computational research. Neuroscience & Biobehavioral Reviews, 2015, 55: 247–267.
Crossref Google Scholar
[78]
Vrieze, E., Pizzagalli, D. A., Demyttenaere, K., Hompes, T., Sienaert, P., de Boer, P., Schmidt, M., Claes, S. Reduced reward learning predicts outcome in major depressive disorder. Biological Psychiatry, 2013, 73(7): 639–645.
Crossref Google Scholar
[79]
Pechtel, P., Dutra, S. J., Goetz, E. L., Pizzagalli, D. A. Blunted reward responsiveness in remitted depression. Journal of Psychiatric Research, 2013, 47(12): 1864–1869.
Crossref Google Scholar
[80]
Cooper, J. A., Gorlick, M. A., Denny, T., Worthy, D. A., Beevers, C. G., Maddox, W. T. Training attention improves decision making in individuals with elevated self-reported depressive symptoms. Cognitive, Affective, & Behavioral Neuroscience, 2014, 14(2): 729–741.
Crossref Google Scholar
[81]
Chase, H. W., Frank, M. J., Michael, A., Bullmore, E. T., Sahakian, B. J., Robbins, T. W. Approach and avoidance learning in patients with major depression and healthy controls: Relation to anhedonia. Psychological Medicine, 2010, 40(3): 433–440.
Crossref Google Scholar
[82]
Dombrovski, A. Y., Szanto, K., Clark, L., Reynolds, C. F., Siegle, G. J. Reward signals, attempted suicide, and impulsivity in late-life depression. JAMA Psychiatry, 2013, 70(10): 1.
Crossref Google Scholar
[83]
Glimcher, P. W. Understanding dopamine and reinforcement learning: The dopamine reward prediction error hypothesis. PNAS, 2011, 108(Supplement_3): 15647–15654.
Crossref Google Scholar
[84]
Niv, Y. Reinforcement learning in the brain. Journal of Mathematical Psychology, 2009, 53(3): 139–154.
Crossref Google Scholar
[85]
Schultz, W. Dopamine signals for reward value and risk: Basic and recent data. Behavioral and Brain Functions, 2010, 6(1): 1–9.
Crossref Google Scholar
[86]
Geugies, H., Mocking, R. J. T., Figueroa, C. A., Groot, P. F. C., Marsman, J. B. C., Servaas, M. N., Steele, J. D., Schene, A. H., Ruhé, H. G. Impaired reward-related learning signals in remitted unmedicated patients with recurrent depression. Brain, 2019, 142(8): 2510–2522.
Crossref Google Scholar
[87]
Rothkirch, M., Tonn, J., Köhler, S., Sterzer, P. Neural mechanisms of reinforcement learning in unmedicated patients with major depressive disorder. Brain, 2017, 140(4): 1147–1157.
Crossref Google Scholar
[88]
Treadway, M. T., Buckholtz, J. W., Schwartzman, A. N., Lambert, W. E., Zald, D. H. Worth the ‘EEfRT’? the effort expenditure for rewards task as an objective measure of motivation and anhedonia. PLoS One, 2009, 4(8): e6598.
Crossref Google Scholar
[89]
Treadway, M. T., Bossaller, N. A., Shelton, R. C., Zald, D. H. Effort-based decision-making in major depressive disorder: A translational model of motivational anhedonia. Journal of Abnormal Psychology, 2012, 121(3): 553–558.
Crossref Google Scholar
[90]
Cléry-Melin, M. L., Schmidt, L., Lafargue, G., Baup, N., Fossati, P., Pessiglione, M. Why don't You try harder? an investigation of effort production in major depression. PLoS One, 2011, 6(8): e23178.
Crossref Google Scholar
[91]
Brinkmann, K., Franzen, J. Not everyone's heart contracts to reward: Insensitivity to varying levels of reward in dysphoria. Biological Psychology, 2013, 94(2): 263–271.
Crossref Google Scholar
[92]
Brinkmann, K., Schüpbach, L., Joye, I. A., Gendolla, G. H. E. Anhedonia and effort mobilization in dysphoria: Reduced cardiovascular response to reward and punishment. International Journal of Psychophysiology, 2009, 74(3): 250–258.
Crossref Google Scholar
[93]
Brinkmann, K., Franzen, J. Blunted cardiovascular reactivity during social reward anticipation in subclinical depression. International Journal of Psychophysiology, 2017, 119: 119–126.
Crossref Google Scholar
[94]
Brinkmann, K., Franzen, J., Rossier, C., Gendolla, G. H. E. I don’t care about others’ approval: Dysphoric individuals show reduced effort mobilization for obtaining a social reward. Motivation and Emotion, 2014, 38(6): 790–801.
Crossref Google Scholar
[95]
Ingram, R. E., Luxton, D. D. Vulnerability-stress models. In: Hankin, B. L., Abela, J. R. (eds.) Development of Psychopathology: A Vulnerability-Stress Perspective. Los Angeles: SAGE Publications, Inc., 2005: 32–46.
Crossref
[96]
Loas, G. Vulnerability to depression: A model centered on anhedonia. Journal of Affective Disorders, 1996, 41(1): 39–53.
Crossref Google Scholar
[97]
Dreher, J. C., Kohn, P., Kolachana, B., Weinberger, D. R., Berman, K. F. Variation in dopamine genes influences responsivity of the human reward system. PNAS, 2009, 106(2): 617–622.
Crossref Google Scholar
[98]
Yacubian, J., Sommer, T., Schroeder, K., Glascher, J., Kalisch, R., Leuenberger, B., Braus, D. F., Buchel, C. Gene gene interaction associated with neural reward sensitivity. PNAS, 2007, 104(19): 8125–8130.
Crossref Google Scholar
[99]
Boecker-Schlier, R., Holz, N. E., Buchmann, A. F., Blomeyer, D., Plichta, M. M., Jennen-Steinmetz, C., Wolf, I., Baumeister, S., Treutlein, J., Rietschel, M. et al. Interaction between COMT Val(158)Met polymorphism and childhood adversity affects reward processing in adulthood. NeuroImage, 2016, 132: 556–570.
Crossref Google Scholar
[100]
Dan, F. T., Hajcak, G. Genetic variation in dopamine moderates neural response during reward anticipation and delivery: Evidence from event-related potentials. Psychophysiology, 2012, 49(5): 617–626.
Crossref Google Scholar
[101]
Aarts, E., Roelofs, A., Franke, B., Rijpkema, M., Fernandez, G., Helmich, R. C., Cools, R. Striatal dopamine mediates the interface between motivational and cognitive control in humans: Evidence from genetic imaging. Neuropsychopharmacology, 2010, 35(9): 1943–1951.
Crossref Google Scholar
[102]
Wittmann, B. C., Tan, G. C., Lisman, J. E., Dolan, R. J., Düzel, E. Reprint of: DAT genotype modulates striatal processing and long-term memory for items associated with reward and punishment. Neuropsychologia, 2013, 51(12): 2469–2477.
Crossref Google Scholar
[103]
Jia, T. Y., Macare, C., Desrivières, S., Gonzalez, D. A., Tao, C. Y., Ji, X. X., Ruggeri, B., Nees, F., Banaschewski, T., Barker, G. J. et al. Neural basis of reward anticipation and its genetic determinants. PNAS, 2016, 113(14): 3879–3884.
Crossref Google Scholar
[104]
Cohen, M. X., Young, J., Baek, J. M., Kessler, C., Ranganath, C. Individual differences in extraversion and dopamine genetics predict neural reward responses. Brain Research. Cognitive Brain Research, 2005, 25(3): 851–861.
Crossref Google Scholar
[105]
Dillon, D. G., Bogdan, R., Fagerness, J., Holmes, A. J., Perlis, R. H., Pizzagalli, D. A. Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans. Human Brain Mapping, 2009, 31(2): 210–221.
Crossref Google Scholar
[106]
Lancaster, T. M., Ihssen, N., Brindley, L. M., Linden, D. J. Further support for association between GWAS variant for positive emotion and reward systems. Translational Psychiatry, 2017, 7(1): e1018.
Crossref Google Scholar
[107]
Corral-Frías, N. S., Pizzagalli, D. A., Carré, J. M., Michalski, L. J., Nikolova, Y. S., Perlis, R. H., Fagerness, J., Lee, M. R., Conley, E. D., Lancaster, T. M. et al. COMT Val(158) Met genotype is associated with reward learning: A replication study and meta-analysis. Genes, Brain, and Behavior, 2016, 15(5): 503–513.
Crossref Google Scholar
[108]
Lancaster, T. M., Heerey, E. A., Mantripragada, K., Linden, D. E. J. Replication study implicates COMT val158met polymorphism as a modulator of probabilistic reward learning. Genes, Brain, and Behavior, 2015, 14(6): 486–492.
Crossref Google Scholar
[109]
Lancaster, T. M., Linden, D. E., Heerey, E. A. COMT val158met predicts reward responsiveness in humans. Genes, Brain, and Behavior, 2012, 11(8): 986–992.
Crossref Google Scholar
[110]
Nikolova, Y., Bogdan, R., Pizzagalli, D. A. Perception of a naturalistic stressor interacts with 5-HTTLPR/rs25531 genotype and gender to impact reward responsiveness. Neuropsychobiology, 2012, 65(1): 45–54.
Crossref Google Scholar
[111]
Bogdan, R., Santesso, D. L., Fagerness, J., Perlis, R. H., Pizzagalli, D. A. Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning. The Journal of Neuroscience, 2011, 31(37): 13246–13254.
Crossref Google Scholar
[112]
Nikolova, Y. S., Ferrell, R. E., Manuck, S. B., Hariri, A. R. Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. Neuropsychopharmacology, 2011, 36(9): 1940–1947.
Crossref Google Scholar
[113]
Stice, E., Yokum, S., Burger, K., Epstein, L., Smolen, A. Multilocus genetic composite reflecting dopamine signaling capacity predicts reward circuitry responsivity. Journal of Neuroscience, 2012, 32(29): 10093–10100.
Crossref Google Scholar
[114]
Bogdan, R., Nikolova, Y. S., Pizzagalli, D. A. Neurogenetics of depression: A focus on reward processing and stress sensitivity. Neurobiology of Disease, 2013, 52: 12–23.
Crossref Google Scholar
[115]
Beck, A. T. Cognitive therapy and the emotional disorders. Oxford: International Universities Press, 1976.
[116]
Ellis, A. J., Beevers, C. G., Wells, T. T. Attention allocation and incidental recognition of emotional information in dysphoria. Cognitive Therapy and Research, 2011, 35(5): 425–433.
Crossref Google Scholar
[117]
Mogg, K., Bradley, B. P. Attentional bias in generalized anxiety disorder versus depressive disorder. Cognitive Therapy and Research, 2005, 29(1): 29–45.
Crossref Google Scholar
[118]
Brailean, A. M., Koster, E. H. W., Hoorelbeke, K., de Raedt, R. Attentional modulation by reward and punishment cues in relation to depressive symptoms. Journal of Behavior Therapy and Experimental Psychiatry, 2014, 45(3): 351–359.
Crossref Google Scholar
[119]
Salem, T., Winer, E. S., Nadorff, M. R. Combined behavioural markers of cognitive biases are associated with anhedonia. Cognition and Emotion, 2018, 32(2): 422–430.
Crossref Google Scholar
[120]
Stanton, C. H., Holmes, A. J., Chang, S. W. C., Joormann, J. From stress to anhedonia: Molecular processes through functional circuits. Trends in Neurosciences, 2019, 42(1): 23–42.
Crossref Google Scholar
[121]
Bekris, S., Antoniou, K., Daskas, S., Papadopoulou-Daifoti, Z. Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. Behavioural Brain Research, 2005, 161(1): 45–59.
Crossref Google Scholar
[122]
Rüedi-Bettschen, D., Pedersen, E. M., Feldon, J., Pryce, C. R. Early deprivation under specific conditions leads to reduced interest in reward in adulthood in Wistar rats. Behavioural Brain Research, 2005, 156(2): 297–310.
Crossref Google Scholar
[123]
Mintz, M., Rüedi-Bettschen, D., Feldon, J., Pryce, C. R. Early social and physical deprivation leads to reduced social motivation in adulthood in Wistar rats. Behavioural Brain Research, 2005, 156(2): 311–320.
Crossref Google Scholar
[124]
Al'Absi, M., Nakajima, M., Hooker, S., Wittmers, L., Cragin, T. Exposure to acute stress is associated with attenuated sweet taste. Psychophysiology, 2012, 49(1): 96–103.
Crossref Google Scholar
[125]
Berenbaum, H., Connelly, J. The effect of stress on hedonic capacity. Journal of Abnormal Psychology, 1993, 102(3): 474–481.
Crossref Google Scholar
[126]
Bogdan, R., Pizzagalli, D. A. Acute stress reduces reward responsiveness: Implications for depression. Biological Psychiatry, 2006, 60(10): 1147–1154.
Crossref Google Scholar
[127]
Berridge, K. C. The debate over dopamine's role in reward: The case for incentive salience. Psychopharmacology, 2007, 191(3): 391–431.
Crossref Google Scholar
[128]
Schultz, W. Predictive reward signal of dopamine neurons. Journal of Neurophysiology, 1998, 80(1): 1–27.
Crossref Google Scholar
[129]
Björklund, A., Dunnett, S. B. Dopamine neuron systems in the brain: An update. Trends in Neurosciences, 2007, 30(5): 194–202.
Crossref Google Scholar
[130]
Mitani, H., Shirayama, Y., Yamada, T., Kawahara, R. Plasma levels of homovanillic acid, 5-hydroxyindoleacetic acid and cortisol, and serotonin turnover in depressed patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006, 30(3): 531–534.
Crossref Google Scholar
[131]
Mitani, H., Shirayama, Y., Yamada, T., Kawahara, R. Plasma levels of homovanillic acid, 5-hydroxyindoleacetic acid and cortisol, and serotonin turnover in depressed patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2006, 30(3): 531–534.
Crossref Google Scholar
[132]
Holmes, E. A., Mathews, A., Dalgleish, T., MacKintosh, B. Positive interpretation training: Effects of mental imagery versus verbal training on positive mood. Behavior Therapy, 2006, 37(3): 237–247.
Crossref Google Scholar
[133]
Holmes, E. A., Lang, T. J., Shah, D. M. Developing interpretation bias modification as a “cognitive vaccine” for depressed mood: Imagining positive events makes You feel better than thinking about them verbally. Journal of Abnormal Psychology, 2009, 118(1): 76–88.
Crossref Google Scholar
[134]
Murphy, S. E., O’Donoghue, M. C., Blackwell, S. E., Nobre, A. C., Browning, M., Holmes, E. A. Increased rostral anterior cingulate activity following positive mental imagery training in healthy older adults. Social Cognitive and Affective Neuroscience, 2017, 12(12): 1950–1958.
Crossref Google Scholar
[135]
Torkan, H., Blackwell, S. E., Holmes, E. A., Kalantari, M., Neshat-Doost, H. T., Maroufi, M., Talebi, H. Positive imagery cognitive bias modification in treatment-seeking patients with major depression in Iran: A pilot study. Cognitive Therapy and Research, 2014, 38(2): 132–145.
Crossref Google Scholar
[136]
Williams, A. D., O’Moore, K., Blackwell, S. E., Smith, J., Holmes, E. A., Andrews, G. Positive imagery cognitive bias modification (CBM) and Internet-based cognitive behavioral therapy (iCBT): A randomized controlled trial. Journal of Affective Disorders, 2015, 178: 131–141.
Crossref Google Scholar
[137]
Holmes, E. A., Mathews, A., MacKintosh, B., Dalgleish, T. The causal effect of mental imagery on emotion assessed using picture-word cues. Emotion (Washington, D.C.), 2008, 8(3): 395–409
Crossref Google Scholar
[138]
Pictet, A., Coughtrey, A. E., Mathews, A., Holmes, E. A. Fishing for happiness: The effects of generating positive imagery on mood and behaviour. Behaviour Research and Therapy, 2011, 49(12): 885–891.
Crossref Google Scholar
[139]
Blackwell, S. E., Holmes, E. A. Modifying interpretation and imagination in clinical depression: A single case series using cognitive bias modification. Applied Cognitive Psychology, 2010, 24(3): 338–350.
Crossref Google Scholar
[140]
Lang, T. J., Blackwell, S. E., Harmer, C. J., Davison, P., Holmes, E. A. Cognitive bias modification using mental imagery for depression: Developing a novel computerized intervention to change negative thinking styles. European Journal of Personality, 2012, 26(2): 145–157.
Crossref Google Scholar
[141]
Blackwell, S. E., Browning, M., Mathews, A., Pictet, A., Welch, J., Davies, J., Watson, P., Geddes, J. R., Holmes, E. A. Positive imagery-based cognitive bias modification as a web-based treatment tool for depressed adults: A randomized controlled trial. Clinical Psychological Science, 2015, 3(1): 91–111.
Crossref Google Scholar
[142]
Renner, F., Ji, J. L., Pictet, A., Holmes, E. A., Blackwell, S. E. Effects of engaging in repeated mental imagery of future positive events on behavioural activation in individuals with major depressive disorder. Cognitive Therapy and Research, 2017, 41(3): 369–380.
Crossref Google Scholar
[143]
McMakin, D. L., Siegle, G. J., Shirk, S. R. Positive affect stimulation and sustainment (PASS) module for depressed mood: A preliminary investigation of treatment-related effects. Cognitive Therapy and Research, 2011, 35(3): 217–226.
Crossref Google Scholar
[144]
Taylor, C. T., Lyubomirsky, S., Stein, M. B. Upregulating the positive affect system in anxiety and depression: Outcomes of a positive activity intervention. Depression and Anxiety, 2017, 34(3): 267–280.
Crossref Google Scholar
[145]
Christopher deCharms, R. Applications of real-time fMRI. Nature Reviews Neuroscience, 2008, 9(9): 720–729.
Crossref Google Scholar
[146]
Drevets, W. C., Price, J. L., Furey, M. L. Brain structural and functional abnormalities in mood disorders: Implications for neurocircuitry models of depression. Brain Structure and Function, 2008, 213(1–2): 93–118.
Crossref Google Scholar
[147]
Sergerie, K., Chochol, C., Armony, J. L. The role of the amygdala in emotional processing: A quantitative meta-analysis of functional neuroimaging studies. Neuroscience & Biobehavioral Reviews, 2008, 32(4): 811–830.
Crossref Google Scholar
[148]
Young, K. D., Siegle, G. J., Bodurka, J., Drevets, W. C. Amygdala activity during autobiographical memory recall in depressed and vulnerable individuals: Association with symptom severity and autobiographical overgenerality. American Journal of Psychiatry, 2016, 173(1): 78–89.
Crossref Google Scholar
[149]
Young, K. D., Siegle, G. J., Zotev, V., Phillips, R., Misaki, M., Yuan, H., Drevets, W. C., Bodurka, J. Randomized clinical trial of real-time fMRI amygdala neurofeedback for major depressive disorder: Effects on symptoms and autobiographical memory recall. American Journal of Psychiatry, 2017, 174(8): 748–755.
Crossref Google Scholar
[150]
Young, K. D., Zotev, V., Phillips, R., Misaki, M., Yuan, H., Drevets, W. C., Bodurka, J. Real-time FMRI neurofeedback training of amygdala activity in patients with major depressive disorder. PLoS One, 2014, 9(2): e88785.
Crossref Google Scholar
[151]
Zhang, Y. J., Wang, H. Y., Yan, C., Wang, L. L., Cheung, E. F. C., Chan, R. C. K. Working memory training can improve anhedonia in college students with subsyndromal depressive symptoms. PsyCh Journal, 2019, 8(4): 401–410.
Crossref Google Scholar
[152]
Jaeggi, S. M., Buschkuehl, M., Jonides, J., Perrig, W. J. Improving fluid intelligence with training on working memory. PNAS, 2008, 105(19): 6829–6833.
Crossref Google Scholar
[153]
Dunn, B. D. Helping depressed clients reconnect to positive emotion experience: Current insights and future directions. Clinical Psychology & Psychotherapy, 2012, 19(4): 326–340.
Crossref Google Scholar
[154]
Shankman, S. A., Katz, A. C., DeLizza, A. A., Sarapas, C., Gorka, S. M., Campbell, M. L. The different facets of anhedonia and their associations with different psychopathologies. In: Ritsner, M., (ed.) Anhedonia: A Comprehensive Handbook Volume I, Dordrecht: Springer, 2014: 3–22.
Crossref
[155]
Kupferberg, A., Bicks, L., Hasler, G. Social functioning in major depressive disorder. Neuroscience & Biobehavioral Reviews, 2016, 69: 313–332.
Crossref Google Scholar
[156]
He, Z., Zhang, D. Social feedback deficits in individuals with depression: The state of art and unsolved problems. Journal of Psychological Science, 2018, 41(1): 237–243. (in Chinese)
Google Scholar
Stress and Brain
Volume 1 Issue 1,
September 2021
Pages 11-32
DOI: 10.26599/SAB.2020.9060002
Cite this article:
Mao J, Yuan J. Anhedonia and its intervention in depressive adults: New developments based on Research Domain Criteria (RDoC) in mental illnesses. Stress and Brain, 2021, 1(1): 11-32. https://doi.org/10.26599/SAB.2020.9060002

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Received: 29 February 2020
Revised: 30 May 2020
Accepted: 22 July 2020
Published: 23 December 2020
© The Author(s) 2020

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