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Research Article | Open Access

Low-Friction Soft Robots for Targeted Bacterial Infection Treatment in Gastrointestinal Tract

Ben Wang1( ), Yunrui Chen1, Zhicheng Ye1, Haidong Yu2, Kai Fung Chan3( ), Tiantian Xu4,5( ), Zhiguang Guo6,7( ), Weimin Liu7, Li Zhang8,9
College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China
Guangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured Materials, School of Resource, Environments and Materials, Guangxi University, Nanning 530004, China
Chow Yuk Ho Technology Centre for Innovative Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
Guangdong Provincial Key Laboratory of Robotics and Intelligent System, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Key Laboratory of Biomedical Imaging Science and System, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Hubei Collaborative Innovation Centre for Advanced Organic Chemical Materials and Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei University, Wuhan 430062, China
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Science, Lanzhou 730000, China
Department of Mechanical and Automation Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China
Multi-Scale Medical Robotics Center, Hong Kong Science Park, Shatin, New Territories, Hong Kong SAR, China
Show Author Information

Abstract

Untethered and self-transformable miniature robots are capable of performing reconfigurable deformation and on-demand locomotion, which aid the traversal toward various lumens, and bring revolutionary changes for targeted delivery in gastrointestinal (GI) tract. However, the viscous non-Newtonian liquid environment and plicae gastricae obstacles severely hamper high-precision actuation and payload delivery. Here, we developed a low-friction soft robot by assembly of densely arranged cone structures and grafting of hydrophobic monolayers. The magnetic orientation encoded robot can move in multiple modes, with a substantially reduced drag, terrain adaptability, and improved motion velocity across the non-Newtonian liquids. Notably, the robot stiffness can be reversibly controlled with magnetically induced hardening, enabling on-site scratching and destruction of antibiotic-ineradicable polymeric matrix in biofilms with a low-frequency magnetic field. Furthermore, the magnetocaloric effect can be utilized to eradicate the bacteria by magnetocaloric effect under high-frequency alternating field. To verify the potential applications inside the body, the clinical imaging-guided actuation platforms were developed for vision-based control and delivery of the robots. The developed low-friction robots and clinical imaging-guided actuation platforms show their high potential to perform bacterial infection therapy in various lumens inside the body.

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Cyborg and Bionic Systems
Volume 5,
2024
Article number: 0138
DOI: 10.34133/cbsystems.0138
Cite this article:
Wang B, Chen Y, Ye Z, et al. Low-Friction Soft Robots for Targeted Bacterial Infection Treatment in Gastrointestinal Tract. Cyborg and Bionic Systems, 2024, 5: 0138. https://doi.org/10.34133/cbsystems.0138

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Received: 31 March 2024
Accepted: 15 May 2024
Published: 05 July 2024
© 2024 Ben Wang et al. Exclusive licensee Beijing Institute of Technology Press. No claim to original U.S. Government Works.

Distributed under a Creative Commons Attribution License 4.0 (CC BY 4.0).
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