AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Nano Biomedicine and Engineering Article
PDF (3.4 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article | Open Access

Impact of Magnesium Oxide Nanoparticles on Erythropoietin Hormone Levels in Sera of Patients with Anemia Accompanied with Diabetic Kidney Disease

Ameer Radhi Sultan1( ), Fatin Fadhel Mohammed Al-Kazazz1, Asma Hadi Mohammed2
Department of Chemistry, College of Science, Al-Mustansiriyah University, Iraq
Department of Physics, College of Science, Al-Mustansiriyah University, Iraq
Show Author Information

Abstract

The present research aimed to study the clinical efficacy of novel of impact of magnesium oxide nanoparticles on erythropoietin hormone in blood. Magnesium oxide nanoparticles (MgO NPs) were prepared by the chemical method. The synthesized nanoparticles were diagnosed via X-ray diffraction (XRD) and transmission electron microscopy (TEM). The average particle size was 10.8-12.6 nm. Blood samples were collected from 68 samples, classified as 24 patients with diabetic, 24 patients with diabetic kidney disease, and a control group of 20 healthy males. The age for all groups ranged between 34-72 years old. For evaluating the effectiveness of the erythropoietin (EPO) hormone with MgO NPs, the results showed a significant increase in the level of erythropoietin hormone with MgO NPs compared with the level of erythropoietin hormone without MgO NPs in patients with diabetic kidney disease (DKD). The activating percentage of erythropoietin hormone action was 84.8%. In conclusion, magnesium oxide nanoparticles may exhibit an impact on erythropoietin hormone and its receptor thus improving the "action", i.e. the binding and interaction between the hormone EPO and its receptors forming their complex. Therefore, the biochemical effects and physiological effects would be more controlled and regulated, thus increasing the level of hemoglobin in the blood and reducing the anemia state.

Keywords

XRDTEMBindingDKDMgO NPsEPO

References

[1]

N.M. Selby, P.J. Blankestijn, P. Boor, et al., Magnetic resonance imaging biomarkers for chronic kidney disease: A position paper from the European Cooperation in Science and Technology Action PARENCHIMA. Nephrol Dial Transplant, 2018, 33(2): 4-14.
Crossref Google Scholar
[2]

K. Umanath, J.B. Lewis, Update on diabetic nephropathy: Core curriculum 2018. Am J Kidney Dis, 2018, 71(6): 884-895.
Crossref Google Scholar
[3]

S.M. Doshi, A.N. Friedman, Diagnosis and management of type 2 diabetic kidney disease. Clin J Am Soc Nephrol, 2017, 12: 1366-1373.
Crossref Google Scholar
[4]

D.W. Coyne, D.I.C. Goldsmith, New options for the anemia of chronic kidney disease. Kidney Int Suppl, 2017, 7(3): 157-163.
Crossref Google Scholar
[5]

D. Vocanec, T. Prijatelj, N. Debeljak, et al., Genetic variants of erythropoietin (EPO) and EPO receptor genes in familial erythrocytosis. Int J Lab Hematol, 2019, 41(2): 162-167.
Crossref Google Scholar
[6]

D. Mohan, M. Railey, Anaemia in a chronic kidney disease patient : The hidden clue. Journal of Clinical & Experimental Nephrology, 2019, 4(2): 1-5.
Google Scholar
[7]

A.H. Ismail, H.K. Al-Bairmani, Z.S. Abbas, et al. Nanoscale synthesis of metal (Ⅱ) theophylline complexes and assessment of their biological activity. Nano Biomed. Eng., 2020, 12(2): 139-147.
Crossref Google Scholar
[8]

A.M. Rheima, D.H. Hussain, and M.M. Almijbilee. Graphene-silver nanocomposite: synthesis, and adsorption study of cibacron blue dye from their aqueous solution. Journal of Southwest Jiaotong University. 2019, 54(6): 1-8.
Crossref Google Scholar
[9]

A.M. Rheima, M.A. Mohammed, S.H. Jaber, et al., Synthesis of silver nanoparticles using the UV-irradiation technique in an antibacterial application. Journal of Southwest Jiaotong University, 2019, 54(5): 1-11.
Crossref Google Scholar
[10]

A.M. Mohammed, A.M. Rheima, S.H. Jaber, et al., The removal of zinc ions from their aqueous solutions by Cr2O3 nanoparticles synthesized via the UV-irradiation method. Egyptian Journal of Chemistry, 2020, 1: 425-431.
Crossref Google Scholar
[11]

A.M. Rheima, M.A. Mohammed, S.H. Jaber, et al., Inhibition effect of silver-calcium nanocomposite on alanine transaminase enzyme activity in human serum of Iraqi patients with chronic liver disease. Drug Invention Today, 2019, 12(11): 2818-2821.
Google Scholar
[12]

A.A. Ali, R.M. Al-Hassani, D.H. Hussain, et al., Synthesis, spectroscopic, characterization, pharmacological evaluation, and cytotoxicity assays of novel nano and micro scale of copper (Ⅱ) complexes against human breast cancer cells. Drug Invention Today, 2020, 14(1): 31-39.
Google Scholar
[13]

D.H. Hussain, A. M, Rheima, and S.H. Jaber., Cadmium ions pollution treatments in aqueous solution using electrochemically synthesized gamma aluminum oxide nanoparticles with DFT study. Egyptian Journal of Chemistry, 2020, 63(2): 417-424.
Crossref Google Scholar
[14]

A.A. Ali, R.M. Al-Hassani, D.H. Hussain, et al., Fabrication of solar cells using novel micro-and nano-complexes of triazole schiff base derivatives. Journal of Southwest Jiaotong University, 2019, 54(6): 1-19.
Crossref Google Scholar
[15]

D.H. Hussain, H.I. Abdulah, and A.M. Rheima., Synthesis and characterization of γ-Fe2O3 nanoparticles photo anode by novel method for dye sensitized solar cell. International Journal of Scientific and Research Publications, 2016, 6: 26-31.
Google Scholar
[16]

S.H. Jabber, D.H. Hussain, A.M. Rheima, et al., Comparing study of CuO synthesized by biological and electrochemical methods for biological activity. Al-Mustansiriyah Journal of Science, 2019, 30: 94-98.
Crossref Google Scholar
[17]

A.H. Ismail, H.K. Al-Bairmani, Z.S. Abbas, et al., Synthesis, characterization, spectroscopic, and biological activity studies of Nano scale Zn(Ⅱ), Mn (Ⅱ) and Fe (Ⅱ) theophylline complexes. Journal of Xi'an University of Architecture & Technology, 2020, Ⅻ (Ⅱ): 2775-2789.
Crossref Google Scholar
[18]

A.H. Ismail, H.K. Al-Bairmani, Z.S. Abbas, et al., Nano-synthesis, spectroscopic characterisation and antibacterial activity of some metal complexes derived from Theophylline. Egyptian Journal of Chemistry, 2020, 63(7): 1-5.
Crossref Google Scholar
[19]

A.M. Rheima, D.H. Hussain, and H.I. Abdulah., Silver nanoparticles : Synthesis, Characterization and their used a counter electrodes in novel Dye sensitizer solar cell. IOSR Journal of Applied Chemistry, 2016, 9: 6-9.
Google Scholar
[20]

A.M. Rheima, M.A. Mohammed, S.H. Jaber, et al. Adsorption of selenium (Se4+) ions pollution by pure rutile titanium dioxide nanosheets electrochemically synthesized. Desalination and Water Treatment. 2020, 194: 187-193.
Crossref Google Scholar
[21]

H.I. Abdulah, D.H. Hussain, and A.M. Rheima, Synthesis of α-Fe2O3, γ-Fe2O3 and Fe3O4 nanoparticles by electrochemical method. Journal of Chemical, Biological and Physical Sciences, 6(4): 1288-1296
Google Scholar
[22]

T.A. Ranathunge, D. Karunaratne, R. Rajapakse, et al., Doxorubicin loaded magnesium oxide nanoflakes as ph dependent carriers for simultaneous treatment of cancer and hypomagnesemia. Nanomaterials, 2019, 9(2): 1-11.
Crossref Google Scholar
[23]

P.R. Dhapake, J.G. Avari, Application of polymeric nanoparticles in oral delivery of recombinant human erythropoietin: A review. J Drug Deliv Ther, 2019, 9: 403-407.
Crossref Google Scholar
[24]

A. Mukhopadhyay, S. Basu, S. Singha, et al., Inner-view of nanomaterial incited protein conformational changes: Insights into designable interaction. Research, 2018, 2018: 1-15.
Crossref Google Scholar
[25]

R. Cagliani, F. Gatto, and G. Bardi., Protein adsorption: A feasible method for nanoparticle functionalization? Materials, 2019, 12(12): 1-11.
Crossref Google Scholar
[26]

S. Devi Meenakshi, M. Rajarajan, S. Rajendran, et al., Synthesis and characterization of magnesium oxide nanoparticles. Elixir Nanotechnol, 2012, 50(9): 10618-10620.
Google Scholar
[27]

A. Mohammed, N. Jassim, and F. Fadhel, Biochemical study for gold and silver nanoparticles on thyroid hormone levels in saliva of patients with chronic renal failure. Eur J Chem, 2013, 4(4): 353-359.
Crossref Google Scholar
[28]

M. Panjeta, I. Tahirovic, E. Sofic, et al., Interpretation of erythropoietin and haemoglobin levels in patients with various stages of chronic kidney disease. J Med Biochem, 2017, 36(2): 145-152.
Crossref Google Scholar
[29]

P. Mirsad, I. Tahirovic, J. Karamehic, et al., The relation of erythropoietin towards hemoglobin and hematocrit in varying degrees of renal insufficiency. Mater Socio Medica, 2015, 27(3): 144-148.
Crossref Google Scholar
[30]

A. Mikhail, C. Brown, J.A. Williams, et al., Renal association clinical practice guideline on Anaemia of Chronic Kidney Disease. BMC Nephrol, 2017, 18(1): 1-29.
Crossref Google Scholar
[31]

S. Bajaj, B. Makkar, V. Abichandani, et al., Management of anemia in patients with diabetic kidney disease: A consensus statement. Indian J Endocrinol Metab, 2016, 20(2): 268-281.
Crossref Google Scholar
[32]

A. Hara, K. Furuichi, A. Koshino, et al., Clinical and pathological significance of autoantibodies to erythropoietin receptor in type 2 diabetic patients with CKD. Kidney Int Reports, 2018, 3(1): 133-141.
Crossref Google Scholar
[33]

J. She, Z. Yuan, Y. Wu, et al., Targeting erythropoietin protects against proteinuria in type 2 diabetic patients and in zebrafish. Mol Metab, 2018, 8(11): 189-202.
Crossref Google Scholar
[34]

J.J. Sutkovic, A review on nanoparticle and protein interaction in biomedical applications. Period Eng Nat Sci, 2016, 4(2): 34-40.
Crossref Google Scholar
[35]

B.E. Fayed, A.F. Tawfik, A. Yassin, Novel erythropoietin-loaded nanoparticles with prolonged in vivo response. J Microencapsul, 2012, 29(7): 650-656.
Crossref Google Scholar
[36]

E. Behzadi, R. Sarsharzadeh, M. Nouri, et al., Albumin binding and anticancer effect of magnesium oxide nanoparticles. Int J Nanomedicine, 2019, 14: 257-270.
Crossref Google Scholar
[37]

A. Alfaro, A. Leon, E. Guajardo-Correa, et al., MgO nanoparticles coated with polyethylene glycol as carrier for 2-Methoxyestradiol anticancer drug. PLoS One, 2019, 14(8): 1-12.
Crossref Google Scholar
[38]

A. Hyochol, W. Michael, L. Debra, et al., Nanotechnology for protein delivery: Overview and perspectives. Physiol Behav, 2017, 176(10): 139-148.
Google Scholar
[39]

W. Kreyling, S. Fertsch-Gapp, M. Schaffler, et al., In vitro and in vivo interactions of selected nanoparticles with rodent serum proteins and their consequences in biokinetics. Beilstein J Nanotechnol, 2014, 5(1): 1699-1711.
Crossref Google Scholar
[40]

Z. Karimpour, S. Rouzbehani, N. Naghsh, The effects of silver nanoparticles on the sex hormones and fetal development in pregnant wistar rats. J Basic Clin Med, 2016, 5(2): 7-10.
Google Scholar
[41]

A. Abdulsattar, Biological impact of gold nanoparticle on estradaiol and testosterone levels in sera of human males. J Fac Med, 2015, 57(4): 333-337.
Crossref Google Scholar
Nano Biomedicine and Engineering
Volume 12 Issue 3,
September 2020
Pages 232-240
DOI: 10.5101/nbe.v12i3.p232-240
Cite this article:
Sultan AR, Al-Kazazz FFM, Mohammed AH. Impact of Magnesium Oxide Nanoparticles on Erythropoietin Hormone Levels in Sera of Patients with Anemia Accompanied with Diabetic Kidney Disease. Nano Biomedicine and Engineering, 2020, 12(3): 232-240. https://doi.org/10.5101/nbe.v12i3.p232-240

674

Views

40

Downloads

2

Crossref

3

Scopus

Altmetrics
Received: 13 April 2020
Accepted: 21 July 2020
Published: 25 August 2020
© Ameer Radhi Sultan, Fatin Fadhel Mohammed Al-Kazazz, and Asma Hadi Mohammed.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Return