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Article | Open Access

Preparation Poly(lactide-co-glycolide) Microsphere of Bone Sialoprotein

Xinmei Liao, Jie Wang( ), Jiangtao Wang, Hongbin Zhang
Department of medical research, Guangzhou general hospital of guanghzou military area,Guangdong Guangzhou 510010, China
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Abstract

OBJECTIVE

To prepare PLGA microsphere of BSP.

METHODS

mulsion solvent extraction-evaporation process was used to prepare microsphere. Technology of preparation was optimized by the orthogonal design. The surface morphology of the microsphere was observed by EM and SEM. The drug loading, the encapsulation efficiency and release rate in vitro were measured using micro-BCA kit.

RESULTS

The mean particle size of the microsphere was 50±0.5 μm, and its mean span was 0.58±0.10, the drug loading and the encapsulation efficiency were (0.725±0.075) % and (64.876±0.680) % respectively. The reappearance of pharmaceutical technology was good.

CONCLUSION

this research described the optimized preparation technology of PLGA microspheres of BSP.

Keywords

Bone sialoproteinPoly(lactide-co-glycolide)Orthogonal design

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Nano Biomedicine and Engineering
Volume 2 Issue 2,
June 2010
Pages 133-137
DOI: 10.5101/nbe.v2i2.p133-137
Cite this article:
Liao X, Wang J, Wang J, et al. Preparation Poly(lactide-co-glycolide) Microsphere of Bone Sialoprotein. Nano Biomedicine and Engineering, 2010, 2(2): 133-137. https://doi.org/10.5101/nbe.v2i2.p133-137

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Received: 15 June 2010
Accepted: 30 June 2010
Published: 01 July 2010
© 2010 X. Liao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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