To prepare PLGA microsphere of BSP.

mulsion solvent extraction-evaporation process was used to prepare microsphere. Technology of preparation was optimized by the orthogonal design. The surface morphology of the microsphere was observed by EM and SEM. The drug loading, the encapsulation efficiency and release rate in vitro were measured using micro-BCA kit.

The mean particle size of the microsphere was 50±0.5 μm, and its mean span was 0.58±0.10, the drug loading and the encapsulation efficiency were (0.725±0.075) % and (64.876±0.680) % respectively. The reappearance of pharmaceutical technology was good.

this research described the optimized preparation technology of PLGA microspheres of BSP.