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Article | Open Access

Experimental Study of Bio-Security of Functionalized Single-Walled and Multi-Walled Carbon Nanotubes

Yongkun Wang1, Qing Lin2, Kejin Wu1( ), Mingjie Zhu3, Yunshu Lu1, Jian Chen1, Shuo Huang1, Xianhua Cheng4, Ziyi Weng5( )
Department of General Surgery, Xinhua hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
Department of Oncology, Xinhua hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
Department of Pathology, Xinhua hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
College of Mechanical and Engineering, Shanghai Jiaotong University, Shanghai 200092, China
Department of Colorectal Surgery, Xinhua hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
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Abstract

In this study, the biological effects of functionalized carbon nanotubes (CNTs) were investigated on cell morphology, proliferation, apoptosis, tissue pathology and blood test in vivo & in vitro. The functionalized CNTs had good biocompatibility at lower concentrations, and the functionalized single-walled carbon nanotubes(SWCNTs) perform in the early period in the animal body and multi-walled carbon nanotubes(MWCNTs) mainly in the late. The results show successful functional groups and no change in toxicity in functional samples compared with the primary sample, and there is a safety dosage on the normal cells and tissue. In subsequent studies, antitumoral investigations of modified samples will be evaluated.

Keywords

functionalized carbon nanotubesbio-securitypathology

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Nano Biomedicine and Engineering
Volume 3 Issue 4,
December 2011
Pages 249-255
DOI: 10.5101/nbe.v3i4.p249-255
Cite this article:
Wang Y, Lin Q, Wu K, et al. Experimental Study of Bio-Security of Functionalized Single-Walled and Multi-Walled Carbon Nanotubes. Nano Biomedicine and Engineering, 2011, 3(4): 249-255. https://doi.org/10.5101/nbe.v3i4.p249-255

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Published: 31 December 2011
© 2011 Y. Wang, et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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