AI Chat Paper
Note: Please note that the following content is generated by AMiner AI. SciOpen does not take any responsibility related to this content.
{{lang === 'zh_CN' ? '文章概述' : 'Summary'}}
{{lang === 'en_US' ? '中' : 'Eng'}}
Chat more with AI
Powered by AMiner. Clicking this button will take you away from SciOpen.
Home Nano Biomedicine and Engineering Article
PDF (1.8 MB)
Cite
EndNote(RIS) BibTeX
Collect
Submit Manuscript AI Chat Paper
Show Outline
Outline
Show full outline
Hide outline
Outline
Show full outline
Hide outline
Research Article | Open Access

Effect of Micro- and Nanoparticles of Ampicillin Trihydrate on Blood Medium: A Voltammetric Study

Muhammed Mizher Radhi1( ), Zuhair Numan Hamed2, Selda Sabah Ezzaldeen2, Emad Abbas Jaffar Al-Mulla3( )
Radiological Techniques Department, Health and Medical Technology College-Baghdad, Middle Technical University (MTU), Iraq
Lab. Techniques Department, Health and Medical Technology College-Baghdad, Middle Technical University (MTU), Iraq
College of Health and Medical Techniques, Al-Furat Al-Awsat Technical University, 54003 Al-Kufa, Iraq
Show Author Information

Abstract

For the first time, one of the antibiotic nanoparticles such as a classical form of ampicillin trihydrate compound was studied. The electrochemical behavior of ampicillin nanoparticles was investigated in blood medium using cyclic voltammetric technique by glassy carbon electrode. The results showed that the oxidation-reduction current peaks of ampicillin nanoparticles in blood medium were different from that of microparticles. The nanoparticles acted as anti-oxidative antibiotic by making the oxidation current peak at 1 V disappear, while the oxidation peak of microparticles still appeared in blood medium; hence, ampicillin at microform acted as oxidative reagent in blood medium. A good reliability and stability of glassy carbon electrode in blood medium was found with low values of RSD for oxidation-reduction current peaks at ±0.52% and ±0.038% respectively. Scanning electron microscopy for the characterization of ampicillin trihydrate nanoparticles was studied.

Keywords

Ampicillin trihydrateCyclic voltammetryNanoparticlesBlood mediumRedox process

References

[1]

M.M. Radhi, Y.K. Abdul-Amir, M.S. Khalaf, Electrochemical Effect of Acetylsalicylic Acid (Aspirin) in Present of Each Ascorbic Acid (AA) and Folic Acid (FA) in Normal Saline and Human Blood Samples, AASCIT Communi., 2016, 3(3): 152-159.
Google Scholar
[2]

M. M. Radhi, N. K. Al-Damlooji, B. K. Abed, Electrochemical Sensors for Detecting Mn (Ⅱ) in Blood Medium. Sensors & Transducers, 2013, 149: 89-93.
Crossref Google Scholar
[3]

S.M.M. Al-Mutoki, A.G. Wadday, and A.A. Abdullah, Effect of nano TiO2 dopant on electrical properties of SR8100/nano TiO2 PMNC. Results Phys., 2016, 6: 551-553.
Crossref Google Scholar
[4]

M.M. Radhi, H.N. Abdullah1, M.S. Jabir et al., Electrochemical effect of ascorbic acid on redox current peaks of CoCl2 in blood medium. Nano Biomed. Eng., 2017, 9 (2): 103-106.
Crossref Google Scholar
[5]

M.M. Radhi, H.N. Abdullah, S.A. Al-Asadi, et al., Electrochemical oxidation effect of ascorbic acid on mercury ions in blood sample using cyclic voltammetry, Int J Ind Chem., 2016, 6 (4): 311-316.
Crossref Google Scholar
[6]

M. M. Radhi, H. N. Abdullah, N. M. Al-Shkir, Electrochemical study of the effect of ascorbic acid on redox current peaks of paracetamol in blood sample, Ir J Biotech., 2015, 14: 63-70
Google Scholar
[7]

H. Meruvu, M. Vangalapati, S. Chaitanya, Synthesis and characterization of zinc oxide nanoparticles and its antimicrobial activity against bacillus subtilis and escherichia coli. Rasayan J Chem., 2011, 4: 217-222.
Google Scholar
[8]

A.N. Brown, K. Smith, T.A. Samuels, et al., Nanoparticles Functionalized with Ampicillin Destroy MultipleAntibiotic-Resistant Isolates of Pseudomonas aeruginosa and Enterobacter aerogenes and Methicillin-Resistant Staphylococcus aureus, Appl Environ Microbiol., 2012, 78(8): 2768-2774.
Crossref Google Scholar
[9]

E. Fattal, J. Rojas, L. Roblot-Treupel, Ampicillinloaded liposomes and nanoparticles: comparison of drug loading, drug release and in vitro antimicrobial activity. J Microencapsulation, 1991, 8: 29-36.
Crossref Google Scholar
[10]

F. Forestier, P. Gerrier, C. Chaumanrd, et al., Effect of nanoparticle-bound ampicillin on the survival of Listeria monocytogenes in mouse peritoneal macrophages. J Antimicrob Chemother (1992) 30 (2): 173-179.
Crossref Google Scholar
[11]

N. Esfandiari, S.M. Ghoreishi, Kinetics modeling of ampicillin nanoparticles synthesis via supercritical gas antisolvent process. J Supercritical Flu., 2013, 8: 119-127.
Crossref Google Scholar
[12]

P. Saha, A.K. Goyal, G. Rath, Formulation and Evaluation of Chitosan-Based Ampicillin Trihydrate Nanoparticles. Tropical PharmaRes., 2010, 9 (5): 483-488.
Crossref Google Scholar
[13]

P. Lingwal, G.K. Bhatt, P. Kothiya, Formulation and evaluation of ampicillin loaded nanoparticles, IAJPS. 2015, 2 (9): 1289-1297.
Google Scholar
[14]

W. Abdelwahed, G. Degobert, S. Stainmesse and H. Fessi, Freeze-drying of nanoparticles: formulation, process and storage considerations. Adva drug deliv revi., 2006, 58(15): 1688-1713.
Crossref Google Scholar
[15]

G.G. Jobitha, S.R. Kumar, G. Annadurai, Preparation and characterization of fruit mediated silver nanoparticles using pomegranate extract and assessment of its antimicrobial activities. J Environ Nanotechnol., 2013, 2 (1): 4-10.
Crossref Google Scholar
[16]

S.M.M. Al-Mutoki, B.A.K. Al-Ghzawi, A.A. Abdullah, et al., Synthesis and characterization of new epoxy/titanium dioxide nanocomposite. Nano Biomed. Eng., 2015, 7 (4): 135-138.
Crossref Google Scholar
[17]

H. Sardarabadi, M. Mashreghi, K. Jamialahmadi, T. Dianat, Resistance of nanobacteria isolated from urinary and kidney stones to broad-spectrum antibiotics. Iran J Microbiol., 2014, 6 (4): 230-233.
Google Scholar
[18]

J. Sochor, J. Dobes, O. Krystofova, et al., Electrochemistry as a Tool for Studying Antioxidant Properties. Int. J. Electrochem. Sci., 2013. 8: 8464-8489.
Google Scholar
[19]

S. Sezgin, M. Ates, A. Elif, Scan Rate Effect of 1-(4-methoxyphenyl)-1H-Pyrrole Electro-coated on Carbon Fiber: Characterization via Cyclic Voltammetry, FTIR-ATR and Electrochemical Impedance Spectroscopy, Int. J. Electrochem. Sci., 2012, 7: 1093-1106.
Google Scholar
[20]

M.M. Rahman, A.J. Ahammad, j. Joon-Hyung, Comprehensive Review of Glucose Biosensors Based on Nanostructured Metal-Oxides, Sensors 2010, 10: 4855-4886.
Crossref Google Scholar
[21]

A.A. Albakry, A.M. Jassim, S.A. Alassady, . Electrochemical study of Pb(Ⅱ) in present of each ascorbic acid, glucose, urea and uric acid using blood medium as an electroly. Nano Biomed. Eng., 2016, 8: 9-15.
Crossref Google Scholar
[22]

S.M.M. Al-Mutoki, m, B.A. Al-Ghzawi, S. AbdulAmohsin, Enhancement of mechanical properties of polyamide hexaglycol by dispersion of TiO2nanofiller. Nano Biomed. Eng., 2016, 8(2): 55-59.
Crossref Google Scholar
[23]

K.W. Al-Janabi, Extraction of cobalt(Ⅱ) from aqueous solution by N, N'-carbonyl difatty amides. Chin Chem Let., 2011, 22(4): 469-472.
Crossref Google Scholar
[24]

M.M. Radhi, H.A.T. Al-Shimmari, E.A.J. Al-Mulla, et al., New Voltammetric Study of MgCl2 as Alternative Contrast Media in MRI Molecular Imaging. Nano Biomed. Eng., 2017, 9(2): 152-161.
Crossref Google Scholar
Nano Biomedicine and Engineering
Volume 9 Issue 3,
September 2017
Pages 185-190
DOI: 10.5101/nbe.v9i3.p185-190
Cite this article:
Radhi MM, Hamed ZN, Ezzaldeen SS, et al. Effect of Micro- and Nanoparticles of Ampicillin Trihydrate on Blood Medium: A Voltammetric Study. Nano Biomedicine and Engineering, 2017, 9(3): 185-190. https://doi.org/10.5101/nbe.v9i3.p185-190

374

Views

4

Downloads

1

Crossref

9

Scopus

Altmetrics
Received: 27 June 2017
Accepted: 09 August 2017
Published: 11 August 2017
© 2017 Muhammed Mizher Radhi, Zuhair Numan Hamed, Selda Sabah Ezzaldeen, and Emad Abbas Jaffar Al-Mulla.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Return