A Review of Methods for Determination of Vanillin in Formulas for Special Medical Purpose Intended for Infants
Abstract
Vanillin is a flavor widely used in the food industry. This paper discusses the application of vanillin in the food industry, worldwide limits for the use of vanillin, the characteristics of the production technology and the possible risks brought by vanillin for foods, and it also summarizes the methods for vanillin detection in dairy products, infant formulas and formulas for special medical purposes intended for infants including gas chromatography (GC), liquid chromatography (LC), gas chromatography-tandem mass spectrometry (GC-MS/MS), liquid chromatography-tandem mass spectrometry (LC-MS/MS), and spectroscopy with special attention to their advantages and limitations. This review is expected to provide a basis for the detection and further research of vanillin in infant formulas for special medical purpose.
Keywords
References
ZIYATDNINOVAG K, ANTONOVAT S, MUBARAKOVAL R, et al. An amperometric sensor based on tin dioxide and cetylpyridinium bromide nanoparticles for the determination of vanillin[J]. Journal of Analytical Chemistry, 2018, 73(8): 801-808. DOI:10.1134/S1061934818080129.
GARCIA B M, SUTTON P W, STRAATMAN H, et al. Biocatalytic synthesis of vanillin by an immobilised eugenol oxidase: high biocatalyst yield by enzyme recycling[J]. Applied Catalysis A: General, 2021, 610: 117934. DOI:10.1016/j.apcata.2020.117934.
ARYA S S, ROOKES J E, CAHILL D M, et al. Vanillin: a review on the therapeutic prospects of a popular flavouring molecule[J]. Advances in Traditional Medicine, 2021, 21: 1-7. DOI:10.1007/S13596-020-00531-W.
ALI L, PERFETTI G, DIACHENKO G. Rapid method for the determination of coumarin, vanillin, and ethyl vanillin in vanilla extract by reversed-phase liquid chromatography with ultraviolet detection[J]. Journal of AOAC International, 2008, 91(2): 383-386.
NI Yongnian, ZHANG Guowen, SERGE K. Simultaneous spectrophotometric determination of maltol, ethyl maltol, vanillin and ethyl vanillin in foods by multivariate calibration and artificial neural networks[J]. Food Chemistry, 2004, 89(3): 465-473. DOI:10.1016/j.foodchem.2004.05.037.
NAIL A. Development of vortex-assisted ionic liquid-dispersive microextraction methodology for vanillin monitoring in food products using ultraviolet-visible spectrophotometry[J]. LWT-Food Science and Technology, 2018, 93: 9-15. DOI:10.1016/j.lwt.2018.03.021.
SUN Yujiao, JIANG Xiaowen, JIN Hui, et al. Ketjen black/ferrocene dual-doped MOFs and aptamer-coupling gold nanoparticles used as a novel ratiometric electrochemical aptasensor for vanillin detection[J]. Analytica Chimica Acta, 2019, 1083(C): 101-109. DOI:10.1016/j.aca.2019.07.027.
DEJAGER L S, PERFETTI G A, DIACHENKO G W. Comparison of headspace-SPME-GC-MS and LC-MS for the detection and quantification of coumarin, vanillin, and ethyl vanillin in vanilla extract products[J]. Food Chemistry, 2007, 107(4): 1701-1709. DOI:10.1016/j.foodchem.2007.09.070.
WANG Zhiyuan, ZENG Guangfeng, WEI Xiaoqun, et al. Determination of vanillin and ethyl-vanillin in milk powder by headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry[J]. Food Analytical Methods, 2016, 9(12): 3360-3366. DOI:10.1007/s12161-016-0520-8.
SHEN Yan, CHAO Han, LIU Bin, et al. Determination of vanillin, ethyl vanillin, and coumarin in infant formula by liquid chromatography-quadrupole linear ion trap mass spectrometry[J]. Journal of Dairy Science, 2014, 97(2): 679-686. DOI:10.3168/jds.2013-7308.
QU Baocheng, JIANG Jingqiu, MAO Xiqin, et al. Simultaneous determination of vanillin, ethyl vanillin and methyl vanillin in Chinese infant food and other dairy products by LC-MS/MS[J]. Food Additives and Contaminants, Part A: Chemistry, Analysis, Control, Exposure and Risk Assessment, 2021, 38(7): 1-9. DOI:10.1080/19440049.2021.1902573.
ZHAO Xin, LI Chunhua, ZHAO Zhilei, et al. Generic models for rapid detection of vanillin and melamine adulterated in infant formulas from diverse brands based on near-infrared hyperspectral imaging[J]. Infrared Physics and Technology, 2021, 116: 103745. DOI:10.1016/j.infrared.2021.103745.
WANG Jing, NI Yonghong. Ammonium molybdate-assisted shape-controlled synthesis of fluorescent Co(Ⅱ)-based MOFs nanoflakes as highly-sensitive probes for selective detection of vanillin in milk powders[J]. Materials Research Bulletin, 2020, 123(C): 110721. DOI:10.1016/j.materresbull.2019.110721.
京公网安备11010802044758号